BS6023

antibody from Bioworld Technology, Inc
Targeting: CASP10 FLICE-2, MCH4
Provider product page for BS6023
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6023 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Caspase 10 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Caspase 10.
Description
Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CASP10 protein structure - BS6023 shown in red.