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Western blotAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- 645202 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#645202, RRID:AB_2275159
- Product name
- Purified anti-Caspase-10
- Antibody type
- Monoclonal
- Antigen
- His tagged bacterial fusion protein of caspase-10 p20
- Description
- There are two types of apoptotic caspases, initiator (apical) caspases and effector (executioner) caspases. Caspase 10 is one of the initiator caspases that cleave inactive pro-forms of effector caspases, thereby activating them. Four isoforms, namely Caspase-10a,-10 b,-10c,and -10d have been identified. They derived from a single chain polypeptide proenzyme but have different mature large and small subunits by cleavage. After the death ligand-receptor binding, caspade-10 has joined the multimeric Fas/TNF receptor complex and gets cleaved. The cleaved caspase-10 further acts on other effector caspases to initiate the caspase cascade.
- Reactivity
- Human, Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store at 4° C.
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Western blot analysis of Hela (lane 1), Jurkat (lane 2) and NIH3T3 (lane 3) cells using anti-caspase-10 antibody (clone 25C2). β-actin antibody (poly6221) was used as loading control.
- Conjugate
- Unconjugated
