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antibody from Novus Biologicals
Targeting: TP53BP1
53BP1, p202, TDRD30
Western blot
Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Proximity ligation assayAntibody data
- Antibody Data
- Antigen structure
- References [86]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Flow cytometry [3]
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- Product number
- NB100-904 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-904, RRID:AB_10002714
- Product name
- Rabbit Polyclonal 53BP1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Other
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at -20 degreesC.
Submitted references LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells.
Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitylase.
Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome.
Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair.
ATM controls DNA repair and mitochondria transfer between neighboring cells.
Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells.
Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division.
DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing.
MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells.
DNA Damage Response Regulates Initiation of Liver Regeneration Following Acetaminophen Overdose.
Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability.
SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage.
Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria.
Regulation of DNA repair in the absence of classical non-homologous end joining.
CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue.
Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes.
Autophagy maintains the metabolism and function of young and old stem cells.
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining.
Integrating phosphoproteomics into the clinical management of prostate cancer.
Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer.
Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication.
A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.
Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells.
Splicing controls the ubiquitin response during DNA double-strand break repair.
Break-induced telomere synthesis underlies alternative telomere maintenance.
A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development.
Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells.
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.
Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks.
Xpg limits the expansion of haematopoietic stem and progenitor cells after ionising radiation.
The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining.
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.
The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1.
Reptin regulates DNA double strand breaks repair in human hepatocellular carcinoma.
Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.
In Vitro Radiosensitization of Esophageal Cancer Cells with the Aminopeptidase Inhibitor CHR-2797.
SPOP mutation leads to genomic instability in prostate cancer.
ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation.
Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome.
Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.
RRP6/EXOSC10 is required for the repair of DNA double-strand breaks by homologous recombination.
Replication fork integrity and intra-S phase checkpoint suppress gene amplification.
Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression.
A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT.
Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.
NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.
Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog.
The RABiT: high-throughput technology for assessing global DSB repair.
The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Statistical analysis of kinetics, distribution and co-localisation of DNA repair foci in irradiated cells: cell cycle effect and implications for prediction of radiosensitivity.
microRNA-34a promotes DNA damage and mitotic catastrophe.
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
Role of TRPM2 and TRPV1 cation channels in cellular responses to radiation-induced DNA damage.
From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin.
ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis.
Expanding the Diversity of Imaging-Based RNAi Screen Applications Using Cell Spot Microarrays.
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.
The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?
Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.
A cell spot microarray method for production of high density siRNA transfection microarrays.
Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor.
The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.
Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin.
Intercellular communication of cellular stress monitored by gamma-H2AX induction.
The mre11 complex and the response to dysfunctional telomeres.
Mammalian Rif1 contributes to replication stress survival and homology-directed repair.
Heat-induced perturbations of DNA damage signaling pathways are modulated by molecular chaperones.
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation.
Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin.
Rad50 is dispensable for the maintenance and viability of postmitotic tissues.
Functional dissection of human and mouse POT1 proteins.
Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ.
Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells.
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
ATM acts downstream of ATR in the DNA damage response signaling of bystander cells.
Role of ATM in the telomere response to the G-quadruplex ligand 360A.
ATR signaling can drive cells into senescence in the absence of DNA breaks.
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
Global chromatin compaction limits the strength of the DNA damage response.
Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14.
Cebrià-Costa JP, Pascual-Reguant L, Gonzalez-Perez A, Serra-Bardenys G, Querol J, Cosín M, Verde G, Cigliano RA, Sanseverino W, Segura-Bayona S, Iturbide A, Andreu D, Nuciforo P, Bernado-Morales C, Rodilla V, Arribas J, Yelamos J, de Herreros AG, Stracker TH, Peiró S
Oncogene 2020 Jan;39(1):79-121
Oncogene 2020 Jan;39(1):79-121
Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitylase.
O'Dea R, Santocanale C
Journal of cell science 2020 Feb 12;133(3)
Journal of cell science 2020 Feb 12;133(3)
Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome.
Bergstrand S, Böhm S, Malmgren H, Norberg A, Sundin M, Nordgren A, Farnebo M
Cell death & disease 2020 Apr 17;11(4):238
Cell death & disease 2020 Apr 17;11(4):238
Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair.
Zhang W, Liao CY, Chtatou H, Incrocci L, van Gent DC, van Weerden WM, Nonnekens J
Cancers 2019 Oct 18;11(10)
Cancers 2019 Oct 18;11(10)
ATM controls DNA repair and mitochondria transfer between neighboring cells.
Jin S, Cordes N
Cell communication and signaling : CCS 2019 Nov 8;17(1):144
Cell communication and signaling : CCS 2019 Nov 8;17(1):144
Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells.
Yost KE, Clatterbuck Soper SF, Walker RL, Pineda MA, Zhu YJ, Ester CD, Showman S, Roschke AV, Waterfall JJ, Meltzer PS
Scientific reports 2019 Mar 14;9(1):4544
Scientific reports 2019 Mar 14;9(1):4544
Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division.
He B, Gnawali N, Hinman AW, Mattingly AJ, Osimani A, Cimini D
Oncotarget 2019 Apr 12;10(28):2660-2674
Oncotarget 2019 Apr 12;10(28):2660-2674
DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing.
Chakraborty P, Huang JTJ, Hiom K
Nature communications 2018 Oct 19;9(1):4346
Nature communications 2018 Oct 19;9(1):4346
MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells.
Bayley R, Blakemore D, Cancian L, Dumon S, Volpe G, Ward C, Almaghrabi R, Gujar J, Reeve N, Raghavan M, Higgs MR, Stewart GS, Petermann E, García P
Cancer research 2018 Oct 15;78(20):5767-5779
Cancer research 2018 Oct 15;78(20):5767-5779
DNA Damage Response Regulates Initiation of Liver Regeneration Following Acetaminophen Overdose.
Borude P, Bhushan B, Apte U
Gene expression 2018 May 18;18(2):115-123
Gene expression 2018 May 18;18(2):115-123
Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability.
Bueno MTD, Baldascini M, Richard S, Lowndes NF
Oncotarget 2018 Mar 23;9(22):15915-15930
Oncotarget 2018 Mar 23;9(22):15915-15930
SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage.
Biswas U, Stevense M, Jessberger R
Current biology : CB 2018 Jan 22;28(2):249-261.e4
Current biology : CB 2018 Jan 22;28(2):249-261.e4
Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria.
Shine EE, Xue M, Patel JR, Healy AR, Surovtseva YV, Herzon SB, Crawford JM
ACS chemical biology 2018 Dec 21;13(12):3286-3293
ACS chemical biology 2018 Dec 21;13(12):3286-3293
Regulation of DNA repair in the absence of classical non-homologous end joining.
Kang YJ, Yan CT
DNA repair 2018 Aug;68:34-40
DNA repair 2018 Aug;68:34-40
CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue.
Bao X, Siprashvili Z, Zarnegar BJ, Shenoy RM, Rios EJ, Nady N, Qu K, Mah A, Webster DE, Rubin AJ, Wozniak GG, Tao S, Wysocka J, Khavari PA
Developmental cell 2017 Oct 23;43(2):227-239.e5
Developmental cell 2017 Oct 23;43(2):227-239.e5
Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes.
Li S, Shu FJ, Li Z, Jaafar L, Zhao S, Dynan WS
DNA repair 2017 Mar;51:70-78
DNA repair 2017 Mar;51:70-78
Autophagy maintains the metabolism and function of young and old stem cells.
Ho TT, Warr MR, Adelman ER, Lansinger OM, Flach J, Verovskaya EV, Figueroa ME, Passegué E
Nature 2017 Mar 9;543(7644):205-210
Nature 2017 Mar 9;543(7644):205-210
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
Sivanand S, Rhoades S, Jiang Q, Lee JV, Benci J, Zhang J, Yuan S, Viney I, Zhao S, Carrer A, Bennett MJ, Minn AJ, Weljie AM, Greenberg RA, Wellen KE
Molecular cell 2017 Jul 20;67(2):252-265.e6
Molecular cell 2017 Jul 20;67(2):252-265.e6
Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
Kang YJ, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, Yan CT
Nature communications 2017 Jan 17;8:14013
Nature communications 2017 Jan 17;8:14013
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J
Cancer discovery 2017 Feb;7(2):165-176
Cancer discovery 2017 Feb;7(2):165-176
SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining.
Jaafar L, Li Z, Li S, Dynan WS
Nucleic acids research 2017 Feb 28;45(4):1848-1859
Nucleic acids research 2017 Feb 28;45(4):1848-1859
Integrating phosphoproteomics into the clinical management of prostate cancer.
Cheng LC, Tan VM, Ganesan S, Drake JM
Clinical and translational medicine 2017 Dec;6(1):9
Clinical and translational medicine 2017 Dec;6(1):9
Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer.
Hassan S, Esch A, Liby T, Gray JW, Heiser LM
Molecular cancer therapeutics 2017 Dec;16(12):2892-2901
Molecular cancer therapeutics 2017 Dec;16(12):2892-2901
Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication.
Foskolou IP, Jorgensen C, Leszczynska KB, Olcina MM, Tarhonskaya H, Haisma B, D'Angiolella V, Myers WK, Domene C, Flashman E, Hammond EM
Molecular cell 2017 Apr 20;66(2):206-220.e9
Molecular cell 2017 Apr 20;66(2):206-220.e9
A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.
Moureau S, Luessing J, Harte EC, Voisin M, Lowndes NF
Open biology 2016 Sep;6(9)
Open biology 2016 Sep;6(9)
Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells.
Moreno A, Carrington JT, Albergante L, Al Mamun M, Haagensen EJ, Komseli ES, Gorgoulis VG, Newman TJ, Blow JJ
Proceedings of the National Academy of Sciences of the United States of America 2016 Sep 27;113(39):E5757-64
Proceedings of the National Academy of Sciences of the United States of America 2016 Sep 27;113(39):E5757-64
Splicing controls the ubiquitin response during DNA double-strand break repair.
Pederiva C, Böhm S, Julner A, Farnebo M
Cell death and differentiation 2016 Oct;23(10):1648-57
Cell death and differentiation 2016 Oct;23(10):1648-57
Break-induced telomere synthesis underlies alternative telomere maintenance.
Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, Greenberg RA
Nature 2016 Nov 3;539(7627):54-58
Nature 2016 Nov 3;539(7627):54-58
A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development.
Byrd PJ, Stewart GS, Smith A, Eaton C, Taylor AJ, Guy C, Eringyte I, Fooks P, Last JI, Horsley R, Oliver AW, Janic D, Dokmanovic L, Stankovic T, Taylor AM
PLoS genetics 2016 Mar;12(3):e1005945
PLoS genetics 2016 Mar;12(3):e1005945
Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.
Surovtseva YV, Jairam V, Salem AF, Sundaram RK, Bindra RS, Herzon SB
Journal of the American Chemical Society 2016 Mar 23;138(11):3844-55
Journal of the American Chemical Society 2016 Mar 23;138(11):3844-55
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells.
Dickreuter E, Eke I, Krause M, Borgmann K, van Vugt MA, Cordes N
Oncogene 2016 Mar 17;35(11):1353-62
Oncogene 2016 Mar 17;35(11):1353-62
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.
Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reverón-Gómez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel DJ, Groth A
Nature 2016 Jun 30;534(7609):714-718
Nature 2016 Jun 30;534(7609):714-718
Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks.
Rassoolzadeh H, Böhm S, Hedström E, Gad H, Helleday T, Henriksson S, Farnebo M
Cell death & disease 2016 Jun 16;7(6):e2267
Cell death & disease 2016 Jun 16;7(6):e2267
Xpg limits the expansion of haematopoietic stem and progenitor cells after ionising radiation.
Avila AI, Illing A, Becker F, Maerz LD, Morita Y, Philipp M, Burkhalter MD
Nucleic acids research 2016 Jul 27;44(13):6252-61
Nucleic acids research 2016 Jul 27;44(13):6252-61
The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining.
Park J, Welner RS, Chan MY, Troppito L, Staber PB, Tenen DG, Yan CT
Journal of immunology (Baltimore, Md. : 1950) 2016 Jan 1;196(1):244-55
Journal of immunology (Baltimore, Md. : 1950) 2016 Jan 1;196(1):244-55
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.
Mackenzie KJ, Carroll P, Lettice L, Tarnauskaitė Ž, Reddy K, Dix F, Revuelta A, Abbondati E, Rigby RE, Rabe B, Kilanowski F, Grimes G, Fluteau A, Devenney PS, Hill RE, Reijns MA, Jackson AP
The EMBO journal 2016 Apr 15;35(8):831-44
The EMBO journal 2016 Apr 15;35(8):831-44
The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1.
Rassoolzadeh H, Coucoravas C, Farnebo M
Nucleus (Austin, Tex.) 2015;6(5):417-24
Nucleus (Austin, Tex.) 2015;6(5):417-24
Reptin regulates DNA double strand breaks repair in human hepatocellular carcinoma.
Raymond AA, Benhamouche S, Neaud V, Di Martino J, Javary J, Rosenbaum J
PloS one 2015;10(4):e0123333
PloS one 2015;10(4):e0123333
Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.
Hartlerode AJ, Morgan MJ, Wu Y, Buis J, Ferguson DO
Nature structural & molecular biology 2015 Sep;22(9):736-43
Nature structural & molecular biology 2015 Sep;22(9):736-43
In Vitro Radiosensitization of Esophageal Cancer Cells with the Aminopeptidase Inhibitor CHR-2797.
Anbalagan S, Biasoli D, Leszczynska KB, Mukherjee S, Hammond EM
Radiation research 2015 Sep;184(3):259-65
Radiation research 2015 Sep;184(3):259-65
SPOP mutation leads to genomic instability in prostate cancer.
Boysen G, Barbieri CE, Prandi D, Blattner M, Chae SS, Dahija A, Nataraj S, Huang D, Marotz C, Xu L, Huang J, Lecca P, Chhangawala S, Liu D, Zhou P, Sboner A, de Bono JS, Demichelis F, Houvras Y, Rubin MA
eLife 2015 Sep 16;4
eLife 2015 Sep 16;4
ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation.
Hausmann C, Temme A, Cordes N, Eke I
Oncotarget 2015 Oct 27;6(33):34592-605
Oncotarget 2015 Oct 27;6(33):34592-605
Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome.
Hedström E, Pederiva C, Farnebo J, Nodin B, Jirström K, Brennan DJ, Farnebo M
Cell death & disease 2015 Oct 1;6(10):e1892
Cell death & disease 2015 Oct 1;6(10):e1892
Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.
Gallina I, Colding C, Henriksen P, Beli P, Nakamura K, Offman J, Mathiasen DP, Silva S, Hoffmann E, Groth A, Choudhary C, Lisby M
Nature communications 2015 Mar 30;6:6533
Nature communications 2015 Mar 30;6:6533
RRP6/EXOSC10 is required for the repair of DNA double-strand breaks by homologous recombination.
Marin-Vicente C, Domingo-Prim J, Eberle AB, Visa N
Journal of cell science 2015 Mar 15;128(6):1097-107
Journal of cell science 2015 Mar 15;128(6):1097-107
Replication fork integrity and intra-S phase checkpoint suppress gene amplification.
Kondratova A, Watanabe T, Marotta M, Cannon M, Segall AM, Serre D, Tanaka H
Nucleic acids research 2015 Mar 11;43(5):2678-90
Nucleic acids research 2015 Mar 11;43(5):2678-90
Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression.
Luo Z, Feng X, Wang H, Xu W, Zhao Y, Ma W, Jiang S, Liu D, Huang J, Songyang Z
Aging cell 2015 Jun;14(3):391-9
Aging cell 2015 Jun;14(3):391-9
A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT.
Hosler GA, Davoli T, Mender I, Litzner B, Choi J, Kapur P, Shay JW, Wang RC
Journal of cutaneous pathology 2015 Feb;42(2):108-17
Journal of cutaneous pathology 2015 Feb;42(2):108-17
Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.
Goglia AG, Delsite R, Luz AN, Shahbazian D, Salem AF, Sundaram RK, Chiaravalli J, Hendrikx PJ, Wilshire JA, Jasin M, Kluger HM, Glickman JF, Powell SN, Bindra RS
Molecular cancer therapeutics 2015 Feb;14(2):326-42
Molecular cancer therapeutics 2015 Feb;14(2):326-42
NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.
Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Chakraborty JB, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA
Nature communications 2015 Apr 16;6:6818
Nature communications 2015 Apr 16;6:6818
Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog.
Li S, Li Z, Shu FJ, Xiong H, Phillips AC, Dynan WS
Nucleic acids research 2014 Sep;42(15):9771-80
Nucleic acids research 2014 Sep;42(15):9771-80
The RABiT: high-throughput technology for assessing global DSB repair.
Turner HC, Sharma P, Perrier JR, Bertucci A, Smilenov L, Johnson G, Taveras M, Brenner DJ, Garty G
Radiation and environmental biophysics 2014 May;53(2):265-72
Radiation and environmental biophysics 2014 May;53(2):265-72
The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.
Henriksson S, Rassoolzadeh H, Hedström E, Coucoravas C, Julner A, Goldstein M, Imreh G, Zhivotovsky B, Kastan MB, Helleday T, Farnebo M
Genes & development 2014 Dec 15;28(24):2726-38
Genes & development 2014 Dec 15;28(24):2726-38
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Flach J, Bakker ST, Mohrin M, Conroy PC, Pietras EM, Reynaud D, Alvarez S, Diolaiti ME, Ugarte F, Forsberg EC, Le Beau MM, Stohr BA, Méndez J, Morrison CG, Passegué E
Nature 2014 Aug 14;512(7513):198-202
Nature 2014 Aug 14;512(7513):198-202
Statistical analysis of kinetics, distribution and co-localisation of DNA repair foci in irradiated cells: cell cycle effect and implications for prediction of radiosensitivity.
Martin OA, Ivashkevich A, Choo S, Woodbine L, Jeggo PA, Martin RF, Lobachevsky P
DNA repair 2013 Oct;12(10):844-55
DNA repair 2013 Oct;12(10):844-55
microRNA-34a promotes DNA damage and mitotic catastrophe.
Kofman AV, Kim J, Park SY, Dupart E, Letson C, Bao Y, Ding K, Chen Q, Schiff D, Larner J, Abounader R
Cell cycle (Georgetown, Tex.) 2013 Nov 15;12(22):3500-11
Cell cycle (Georgetown, Tex.) 2013 Nov 15;12(22):3500-11
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA
Nature structural & molecular biology 2013 Mar;20(3):317-25
Nature structural & molecular biology 2013 Mar;20(3):317-25
Role of TRPM2 and TRPV1 cation channels in cellular responses to radiation-induced DNA damage.
Masumoto K, Tsukimoto M, Kojima S
Biochimica et biophysica acta 2013 Jun;1830(6):3382-90
Biochimica et biophysica acta 2013 Jun;1830(6):3382-90
From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin.
Fedor Y, Vignard J, Nicolau-Travers ML, Boutet-Robinet E, Watrin C, Salles B, Mirey G
Cellular microbiology 2013 Jan;15(1):1-15
Cellular microbiology 2013 Jan;15(1):1-15
ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis.
Naim V, Wilhelm T, Debatisse M, Rosselli F
Nature cell biology 2013 Aug;15(8):1008-15
Nature cell biology 2013 Aug;15(8):1008-15
Expanding the Diversity of Imaging-Based RNAi Screen Applications Using Cell Spot Microarrays.
Rantala JK, Kwon S, Korkola J, Gray JW
Microarrays (Basel, Switzerland) 2013 Apr 11;2(2):97-114
Microarrays (Basel, Switzerland) 2013 Apr 11;2(2):97-114
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.
Hewitt G, Jurk D, Marques FD, Correia-Melo C, Hardy T, Gackowska A, Anderson R, Taschuk M, Mann J, Passos JF
Nature communications 2012 Feb 28;3:708
Nature communications 2012 Feb 28;3:708
The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?
Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, Rodier F, Davalos AR, Gewirtz DA
The Journal of pharmacology and experimental therapeutics 2012 Dec;343(3):763-78
The Journal of pharmacology and experimental therapeutics 2012 Dec;343(3):763-78
Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.
Zhang YW, Regairaz M, Seiler JA, Agama KK, Doroshow JH, Pommier Y
Nucleic acids research 2011 May;39(9):3607-20
Nucleic acids research 2011 May;39(9):3607-20
A cell spot microarray method for production of high density siRNA transfection microarrays.
Rantala JK, Mäkelä R, Aaltola AR, Laasola P, Mpindi JP, Nees M, Saviranta P, Kallioniemi O
BMC genomics 2011 Mar 28;12:162
BMC genomics 2011 Mar 28;12:162
Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor.
Monaco-Shawver L, Schwartz L, Tuluc F, Guo CJ, Lai JP, Gunnam SM, Kilpatrick LE, Banerjee PP, Douglas SD, Orange JS
Journal of leukocyte biology 2011 Jan;89(1):113-25
Journal of leukocyte biology 2011 Jan;89(1):113-25
The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.
Coleman KA, Greenberg RA
The Journal of biological chemistry 2011 Apr 15;286(15):13669-80
The Journal of biological chemistry 2011 Apr 15;286(15):13669-80
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.
Rizzo A, Salvati E, Porru M, D'Angelo C, Stevens MF, D'Incalci M, Leonetti C, Gilson E, Zupi G, Biroccio A
Nucleic acids research 2009 Sep;37(16):5353-64
Nucleic acids research 2009 Sep;37(16):5353-64
Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin.
Spardy N, Covella K, Cha E, Hoskins EE, Wells SI, Duensing A, Duensing S
Cancer research 2009 Sep 1;69(17):7022-9
Cancer research 2009 Sep 1;69(17):7022-9
Intercellular communication of cellular stress monitored by gamma-H2AX induction.
Dickey JS, Baird BJ, Redon CE, Sokolov MV, Sedelnikova OA, Bonner WM
Carcinogenesis 2009 Oct;30(10):1686-95
Carcinogenesis 2009 Oct;30(10):1686-95
The mre11 complex and the response to dysfunctional telomeres.
Attwooll CL, Akpinar M, Petrini JH
Molecular and cellular biology 2009 Oct;29(20):5540-51
Molecular and cellular biology 2009 Oct;29(20):5540-51
Mammalian Rif1 contributes to replication stress survival and homology-directed repair.
Buonomo SB, Wu Y, Ferguson D, de Lange T
The Journal of cell biology 2009 Nov 2;187(3):385-98
The Journal of cell biology 2009 Nov 2;187(3):385-98
Heat-induced perturbations of DNA damage signaling pathways are modulated by molecular chaperones.
Laszlo A, Fleischer I
Cancer research 2009 Mar 1;69(5):2042-9
Cancer research 2009 Mar 1;69(5):2042-9
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation.
Yu Z, Chen T, Hébert J, Li E, Richard S
Molecular and cellular biology 2009 Jun;29(11):2982-96
Molecular and cellular biology 2009 Jun;29(11):2982-96
Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin.
Guirouilh-Barbat J, Zhang YW, Pommier Y
Molecular cancer therapeutics 2009 Jul;8(7):1985-94
Molecular cancer therapeutics 2009 Jul;8(7):1985-94
Rad50 is dispensable for the maintenance and viability of postmitotic tissues.
Adelman CA, De S, Petrini JH
Molecular and cellular biology 2009 Jan;29(2):483-92
Molecular and cellular biology 2009 Jan;29(2):483-92
Functional dissection of human and mouse POT1 proteins.
Palm W, Hockemeyer D, Kibe T, de Lange T
Molecular and cellular biology 2009 Jan;29(2):471-82
Molecular and cellular biology 2009 Jan;29(2):471-82
Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ.
Hsiao SJ, Smith S
The Journal of cell biology 2009 Feb 23;184(4):515-26
The Journal of cell biology 2009 Feb 23;184(4):515-26
Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells.
Cadot B, Brunetti M, Coppari S, Fedeli S, de Rinaldis E, Dello Russo C, Gallinari P, De Francesco R, Steinkühler C, Filocamo G
Cancer research 2009 Aug 1;69(15):6074-82
Cancer research 2009 Aug 1;69(15):6074-82
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
Guirouilh-Barbat J, Redon C, Pommier Y
Molecular biology of the cell 2008 Sep;19(9):3969-81
Molecular biology of the cell 2008 Sep;19(9):3969-81
ATM acts downstream of ATR in the DNA damage response signaling of bystander cells.
Burdak-Rothkamm S, Rothkamm K, Prise KM
Cancer research 2008 Sep 1;68(17):7059-65
Cancer research 2008 Sep 1;68(17):7059-65
Role of ATM in the telomere response to the G-quadruplex ligand 360A.
Pennarun G, Granotier C, Hoffschir F, Mandine E, Biard D, Gauthier LR, Boussin FD
Nucleic acids research 2008 Mar;36(5):1741-54
Nucleic acids research 2008 Mar;36(5):1741-54
ATR signaling can drive cells into senescence in the absence of DNA breaks.
Toledo LI, Murga M, Gutierrez-Martinez P, Soria R, Fernandez-Capetillo O
Genes & development 2008 Feb 1;22(3):297-302
Genes & development 2008 Feb 1;22(3):297-302
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T
Genes & development 2008 Aug 1;22(15):2048-61
Genes & development 2008 Aug 1;22(15):2048-61
Global chromatin compaction limits the strength of the DNA damage response.
Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, Yang SM, Blasco MA, Skoultchi AI, Fernandez-Capetillo O
The Journal of cell biology 2007 Sep 24;178(7):1101-8
The Journal of cell biology 2007 Sep 24;178(7):1101-8
Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14.
Yanagawa T, Funasaka T, Tsutsumi S, Hu H, Watanabe H, Raz A
Cancer research 2007 Sep 15;67(18):8682-9
Cancer research 2007 Sep 15;67(18):8682-9
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: 53BP1 Antibody [NB100-904] - Western blot analysis of untreated U2OS cell lysate blotted with 53BP1 Antibody. The observed molecular weight here is ~220 kDa, and the theoretical molecular weight is 214 kDa.
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- Novus Biologicals (provider)
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- Western Blot: 53BP1 Antibody [NB100-904] - WRAP53beta plays an important role in recruitment of factors involved in HR and NHEJ to DNA breaks in A2780 cells. A2780 cells were transfected with siControl or siWRAP53#2 oligonucleotides for 48 h; exposed to IR (6 Gy), and 1 h later immunostained for WRAP53beta, gamma-H2AX, MDC1, RNF168, 53BP1, RAD51 and beta-actin. We could not assess the protein levels of BRCA1 due to a lack of antibodies that work for western blotting. The observed molecular weight is 275 kDa and the theoretical molecular weight for the whole endogenous protein is 214 kDa. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/cddis2015250) licensed under a CC-BY licence.
Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: 53BP1 Antibody [NB100-904] - Staining of 53BP1 in human renal cancer cells using DAB with hematoxylin counterstain.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: 53BP1 Antibody [NB100-904] - An intracellular stain was performed on HeLa cells (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to DyLight 550.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: 53BP1 Antibody [NB100-904] - An intracellular stain was performed on HeLa cells with 53BP1 Antibody (Catalog #NB100-904AF647) (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 647.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: 53BP1 Antibody [NB100-904] - An intracellular stain was performed on HeLa cells with 53BP1 Antibody (Catalog #NB100-904C) (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to DyLight 650.
