619002
antibody from BioLegend
Targeting: TP63
EEC3, KET, NBP, OFC8, p51, p53CP, p63, p73H, p73L, SHFM4, TP53CP, TP53L, TP73L
Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 619002 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#619002, RRID:AB_2207170
- Product name
- Purified anti-p63 (N)
- Antibody type
- Polyclonal
- Antigen
- Modified peptide
- Description
- p63 (ΔN) is a member of the p53 family. This protein has multiple isoforms TA p63-α, -β, γ, ΔN p63-α, -β, and -γ. The molecular weights of the p63 isoforms α=66 kD, β=52 kD, and γ=45 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, and epithelial stem cell regeneration. ΔN isoforms are antagonistic to p53; TA isoforms can transactivate p53 targets. The p63 ΔN isoforms repress TA isoforms; mutant p53 abrogates p63 transactivation. This protein interacts with p53, p73, and the various TA- and ΔN isoforms. The Poly6190 antibody recognizes human p63 ΔN isoforms and has been shown to be useful for Western blotting.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 200 µl
- Storage
- Upon receipt, store frozen at -20° C.
Submitted references A contact lens-based technique for expansion and transplantation of autologous epithelial progenitors for ocular surface reconstruction.
DeltaNp63 is essential for epidermal commitment of embryonic stem cells.
Di Girolamo N, Bosch M, Zamora K, Coroneo MT, Wakefield D, Watson SL
Transplantation 2009 May 27;87(10):1571-8
Transplantation 2009 May 27;87(10):1571-8
DeltaNp63 is essential for epidermal commitment of embryonic stem cells.
Medawar A, Virolle T, Rostagno P, de la Forest-Divonne S, Gambaro K, Rouleau M, Aberdam D
PloS one 2008;3(10):e3441
PloS one 2008;3(10):e3441
No comments: Submit comment
Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Immunofluorescent microscope analysis of Hela cells using anti-p63 ?N polyclonal antibody (poly6190) (red). a-tubulin (clone 10D8) has been labeled with green and nuclei were stain with DAPI (blue).
- Conjugate
- Unconjugated