BS3163

antibody from Bioworld Technology, Inc

Targeting: FZD2

Immunocytochemistry

Antibody data

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Validation data

Product number: BS3163 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS3163, RRID:AB_1662544
Product name: Frizzled 2 (E240) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 208-260 of Human Frizzled-2.
Description: The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy-terminal Ser/Thr-XXX-Val motif. The proteins in this family function as receptors for Wnt and are generally coupled to G proteins. Frizzleds are members of the G protein-coupled receptor superfamily. Frizzled-2 is expressed in the fetal kidney and lung and in the adult ovary and colon. Frizzled-2 mediates the Wnt/cGMP/Ca2+ pathway. It binds Wnt proteins and signals by activating the release of stored calcium. Frizzled-2 expression is regulated by Angiotensin II. Activated frizzled-2 suppresses the activity of protein kinase G, and activates NFAT-dependent transcription, the phosphatidylinositol pathway and calcium sensitive enzymes.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

FZD2 protein structure - BS3163 shown in red.