14497-1-AP

antibody from Proteintech Group

Targeting: TSG101 TSG10, VPS23

Provider product page for 14497-1-AP

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Antibody data

Antibody Data
Antigen structure
References [153]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

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Product number: 14497-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14497-1-AP, RRID:AB_2208090
Product name: TSG101 antibody
Antibody type: Polyclonal
Description: KD/KO validated TSG101 antibody (Cat. #14497-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TSG101 protein structure - 14497-1-AP shown in red.

Submitted references Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease.

Carrascal M, Areny-Balagueró A, de-Madaria E, Cárdenas-Jaén K, García-Rayado G, Rivera R, Martin Mateos RM, Pascual-Moreno I, Gironella M, Abian J, Closa D
The Journal of pathology 2022 Jan;256(1):83-92

Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration.

Li S, Liao Z, Luo R, Song Y, Wang K, Feng X, Ou Y, Wu X, Zhang Y, Gao Y, Yin H, Yang C
Frontiers in cell and developmental biology 2021;9:672847

Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.

Luo L, Gong J, Zhang H, Qin J, Li C, Zhang J, Tang Y, Zhang Y, Chen J, Zhou Y, Tian Z, Liu Y, Liu M
Frontiers in cell and developmental biology 2021;9:648201

Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model.

Gu L, Ren F, Fang X, Yuan L, Liu G, Wang S
Frontiers in medicine 2021;8:660614

Exosomes released from mesenchymal stem cells overexpressing microRNA-30e ameliorate heart failure in rats with myocardial infarction.

Pu L, Kong X, Li H, He X
American journal of translational research 2021;13(5):4007-4025

Osteosarcoma Cell-Derived Small Extracellular Vesicles Enhance Osteoclastogenesis and Bone Resorption Through Transferring MicroRNA-19a-3p.

Luo T, Zhou X, Jiang E, Wang L, Ji Y, Shang Z
Frontiers in oncology 2021;11:618662

The effect of traumatic brain injury on bone healing from a novel exosome centered perspective in a mice model.

Yang C, Gao C, Liu N, Zhu Y, Zhu X, Su X, Zhang Q, Wu Y, Zhang C, Liu A, Lin W, Tao L, Yang H, Lin J
Journal of orthopaedic translation 2021 Sep;30:70-81

A novel delivery nanobiotechnology: engineered miR-181b exosomes improved osteointegration by regulating macrophage polarization.

Liu W, Yu M, Chen F, Wang L, Ye C, Chen Q, Zhu Q, Xie D, Shao M, Yang L
Journal of nanobiotechnology 2021 Sep 7;19(1):269

Plasma‑derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.

Yang L, Zheng S, Liu Q, Liu T, Zhang Q, Han X, Tuerxun A, Lu X
Oncology reports 2021 Oct;46(4)

CD151 enrichment in exosomes of luminal androgen receptor breast cancer cell line contributes to cell invasion.

Li D, Lai W, Wang Q, Xiang Z, Nan X, Yang X, Fang Q
Biochimie 2021 Oct;189:65-75

Repair of peripheral nerve defects by nerve grafts incorporated with extracellular vesicles from skin-derived precursor Schwann cells.

Yu M, Gu G, Cong M, Du M, Wang W, Shen M, Zhang Q, Shi H, Gu X, Ding F
Acta biomaterialia 2021 Oct 15;134:190-203

Mussel-inspired functionalization of electrospun scaffolds with polydopamine-assisted immobilization of mesenchymal stem cells-derived small extracellular vesicles for enhanced bone regeneration.

Xing X, Han S, Ni Y, Cheng G, Cheng Y, Ni X, Deng Y, Li Z, Li Z
International journal of pharmaceutics 2021 Nov 20;609:121136

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.

Kazan JM, Desrochers G, Martin CE, Jeong H, Kharitidi D, Apaja PM, Roldan A, St Denis N, Gingras AC, Lukacs GL, Pause A
iScience 2021 Nov 19;24(11):103274

Plasma exosomes from depression ameliorate inflammation-induced depressive-like behaviors via sigma-1 receptor delivery.

Wang Y, Gao C, Gao T, Zhao L, Zhu S, Guo L
Brain, behavior, and immunity 2021 May;94:225-234

Macrophage-derived exosomes mediate silica-induced pulmonary fibrosis by activating fibroblast in an endoplasmic reticulum stress-dependent manner.

Qin X, Lin X, Liu L, Li Y, Li X, Deng Z, Chen H, Chen H, Niu Z, Li Z, Hu Y
Journal of cellular and molecular medicine 2021 May;25(9):4466-4477

Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA.

Cheng Q, Li Q, Xu L, Jiang H
Molecular medicine reports 2021 May;23(5)

Selective packaged circular RNAs in milk extracellular vesicles during Staphylococcus aureus infection may have potential against bacterial infection.

Ma S, Niu M, Hao Z, Liu M, Tong C, Zhao X
RNA biology 2021 May;18(5):818-831

Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.

Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060

Endometrial cell-derived small extracellular vesicle miR-100-5p promotes functions of trophoblast during embryo implantation.

Tan Q, Shi S, Liang J, Cao D, Wang S, Wang Z
Molecular therapy. Nucleic acids 2021 Mar 5;23:217-231

Concentrated exosomes from menstrual blood-derived stromal cells improves ovarian activity in a rat model of premature ovarian insufficiency.

Zhang S, Huang B, Su P, Chang Q, Li P, Song A, Zhao X, Yuan Z, Tan J
Stem cell research & therapy 2021 Mar 12;12(1):178

Osteosarcoma-derived exosomal miR-501-3p promotes osteoclastogenesis and aggravates bone loss.

Lin L, Wang H, Guo W, He E, Huang K, Zhao Q
Cellular signalling 2021 Jun;82:109935

CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice.

Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, Hu H, Guan X, Ma W, Zhang Y, He Y, Liu B, Tang S, Jiang W, Xue J, Xin H
Signal transduction and targeted therapy 2021 Jun 11;6(1):223

Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model.

Duan A, Shen K, Li B, Li C, Zhou H, Kong R, Shao Y, Qin J, Yuan T, Ji J, Guo W, Wang X, Xue T, Li L, Huang X, Sun Y, Cai Z, Liu W, Liu F
Stem cell research & therapy 2021 Jul 28;12(1):427

Circulating PD-L1 is associated with T cell infiltration and predicts prognosis in patients with CRLM following hepatic resection.

Chen X, Du Z, Huang M, Wang D, Fong WP, Liang J, Fan L, Wang Y, Yang H, Chen Z, Hu M, Xu R, Li Y
Cancer immunology, immunotherapy : CII 2021 Jul 28;

Rapid communication: insights into the role of extracellular vesicles during Auger radioimmunotherapy.

Karam J, Constanzo J, Pichard A, Gros L, Chopineau J, Morille M, Pouget JP
International journal of radiation biology 2021 Jul 26;:1-10

A novel strategy to identify candidate diagnostic and prognostic biomarkers for gastric cancer.

Liu L, Pang H, He Q, Pan B, Sun X, Shan J, Wu L, Wu K, Yao X, Guo Y
Cancer cell international 2021 Jul 2;21(1):335

Osteocyte exosomes accelerate benign prostatic hyperplasia development.

Wang YY, Xia K, Wang ZX, Xie H, Xu R
Molecular and cellular endocrinology 2021 Jul 1;531:111301

SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation.

Huang R, Hao C, Wang D, Zhao Q, Li C, Wang C, Yao W
Toxicology and applied pharmacology 2021 Jul 1;422:115559

Local delivery of USC-derived exosomes harboring ANGPTL3 enhances spinal cord functional recovery after injury by promoting angiogenesis.

Cao Y, Xu Y, Chen C, Xie H, Lu H, Hu J
Stem cell research & therapy 2021 Jan 7;12(1):20

Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke.

Yang J, Cao LL, Wang XP, Guo W, Guo RB, Sun YQ, Xue TF, Cai ZY, Ji J, Cheng H, Sun XL
Cell death & disease 2021 Jan 6;12(1):23

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.

Zhao M, Liu S, Wang C, Wang Y, Wan M, Liu F, Gong M, Yuan Y, Chen Y, Cheng J, Lu Y, Liu J
ACS nano 2021 Jan 26;15(1):1519-1538

Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells.

Cong M, Shen M, Wu X, Li Y, Wang L, He Q, Shi H, Ding F
Stem cell research & therapy 2021 Jan 25;12(1):80

Association of exosomal microRNAs in human ovarian follicular fluid with oocyte quality.

Zhang D, Lv J, Tang R, Feng Y, Zhao Y, Fei X, Chian R, Xie Q
Biochemical and biophysical research communications 2021 Jan 1;534:468-473

Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p.

Zhu W, Sun L, Zhao P, Liu Y, Zhang J, Zhang Y, Hong Y, Zhu Y, Lu Y, Zhao W, Chen X, Zhang F
Journal of nanobiotechnology 2021 Feb 27;19(1):61

Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway.

Cao W, Zeng Z, He Z, Lei S
Aging 2021 Feb 26;13(5):7120-7132

GBA Mutations Influence the Release and Pathological Effects of Small Extracellular Vesicles from Fibroblasts of Patients with Parkinson's Disease.

Cerri S, Ghezzi C, Ongari G, Croce S, Avenali M, Zangaglia R, Di Monte DA, Valente EM, Blandini F
International journal of molecular sciences 2021 Feb 23;22(4)

Exosomes secreted from mesenchymal stem cells mediate the regeneration of endothelial cells treated with rapamycin by delivering pro-angiogenic microRNAs.

Wang W, Zhao Y, Li H, Zhang Y, Jia X, Wang C, Zhu P, Wang J, Hou Y
Experimental cell research 2021 Feb 1;399(1):112449

Adipose-derived mesenchymal stem cell exosomes inhibit transforming growth factor-β1-induced collagen synthesis in oral mucosal fibroblasts.

Liu J, Li F, Liu B, Yao Z, Li L, Liu G, Peng L, Wang Y, Huang J
Experimental and therapeutic medicine 2021 Dec;22(6):1419

Extracellular vesicles derived from lipoaspirate fluid promote fat graft survival.

Nie F, Ding P, Zhang C, Zhao Z, Bi H
Adipocyte 2021 Dec;10(1):293-309

Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging.

Liu SJ, Meng MY, Han S, Gao H, Zhao YY, Yang Y, Lin ZY, Yang LR, Zhu K, Han R, Huang WW, Wang RQ, Yang LL, Wang WJ, Li L, Wang XD, Hou ZL, Liao LW, Yang L
Rejuvenation research 2021 Aug;24(4):283-293

Serum exosomal pregnancy zone protein as a promising biomarker in inflammatory bowel disease.

Shao J, Jin Y, Shao C, Fan H, Wang X, Yang G
Cellular & molecular biology letters 2021 Aug 10;26(1):36

Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.

Luo L, Jian X, Sun H, Qin J, Wang Y, Zhang J, Shen Z, Yang D, Li C, Zhao P, Liu M, Tian Z, Zhou Y
Stem cells (Dayton, Ohio) 2021 Apr;39(4):467-481

Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells.

Fu G, Lu L, Pan Z, Fan A, Yin F
Regenerative medicine 2021 Apr;16(4):359-372

The tissue origin effect of extracellular vesicles on cartilage and bone regeneration.

Li Q, Yu H, Sun M, Yang P, Hu X, Ao Y, Cheng J
Acta biomaterialia 2021 Apr 15;125:253-266

Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles.

Jiang W, Ma P, Deng L, Liu Z, Wang X, Liu X, Long G
Journal of extracellular vesicles 2020;9(1):1716513

Exosomes derived from human amniotic epithelial cells accelerate diabetic wound healing via PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast function.

Wei P, Zhong C, Yang X, Shu F, Xiao S, Gong T, Luo P, Li L, Chen Z, Zheng Y, Xia Z
Burns & trauma 2020;8:tkaa020

Down-Regulated Exosomal MicroRNA-221 - 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair.

Sun L, Zhu W, Zhao P, Zhang J, Lu Y, Zhu Y, Zhao W, Liu Y, Chen Q, Zhang F
Frontiers in cell and developmental biology 2020;8:263

Chen S, Wang Y, Liao L, Meng L, Li J, Shi C, Han H, Zheng X, Shen H
Stem cells international 2020;2020:8861557

OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway.

Wang H, Wang L, Zhou X, Luo X, Liu K, Jiang E, Chen Y, Shao Z, Shang Z
BioMed research international 2020;2020:2125656

Ultraviolet B irradiation enhances the secretion of exosomes by human primary melanocytes and changes their exosomal miRNA profile.

Shen Z, Sun J, Shao J, Xu J
PloS one 2020;15(8):e0237023

Exosomes Derived from Hypoxic Colorectal Cancer Cells Transfer miR-410-3p to Regulate Tumor Progression.

Hu X, Mu Y, Liu J, Mu X, Gao F, Chen L, Wu H, Wu H, Liu W, Zhao Y
Journal of Cancer 2020;11(16):4724-4735

Urinary Exosomal MiRNA-4534 as a Novel Diagnostic Biomarker for Diabetic Kidney Disease.

Zhao Y, Shen A, Guo F, Song Y, Jing N, Ding X, Pan M, Zhang H, Wang J, Wu L, Ma X, Feng L, Qin G
Frontiers in endocrinology 2020;11:590

M1 Macrophage Derived Exosomes Aggravate Experimental Autoimmune Neuritis via Modulating Th1 Response.

Du T, Yang CL, Ge MR, Liu Y, Zhang P, Li H, Li XL, Li T, Liu YD, Dou YC, Yang B, Duan RS
Frontiers in immunology 2020;11:1603

Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.

Hu Y, Zhang Y, Ni CY, Chen CY, Rao SS, Yin H, Huang J, Tan YJ, Wang ZX, Cao J, Liu ZZ, Xie PL, Wu B, Luo J, Xie H
Theranostics 2020;10(5):2293-2308

Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma.

Zhang K, Dong C, Chen M, Yang T, Wang X, Gao Y, Wang L, Wen Y, Chen G, Wang X, Yu X, Zhang Y, Wang P, Shang M, Han K, Zhou Y
Theranostics 2020;10(1):411-425

Plasma Exosomal miRNA Expression Profile as Oxaliplatin-Based Chemoresistant Biomarkers in Colorectal Adenocarcinoma.

Han J, Sun W, Liu R, Zhou Z, Zhang H, Chen X, Ba Y
Frontiers in oncology 2020;10:1495

circFMN2 Sponges miR-1238 to Promote the Expression of LIM-Homeobox Gene 2 in Prostate Cancer Cells.

Shan G, Shao B, Liu Q, Zeng Y, Fu C, Chen A, Chen Q
Molecular therapy. Nucleic acids 2020 Sep 4;21:133-146

Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo.

Khodayari N, Oshins R, Holliday LS, Clark V, Xiao Q, Marek G, Mehrad B, Brantly M
Cell communication and signaling : CCS 2020 Sep 4;18(1):140

Bovine Milk Exosomes Affect Proliferation and Protect Macrophages against Cisplatin-Induced Cytotoxicity.

Matic S, D'Souza DH, Wu T, Pangloli P, Dia VP
Immunological investigations 2020 Oct;49(7):711-725

Down-regulation of exosomal miR-200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis.

Zhao C, Wang D, Wang X, Mao Y, Xu Z, Sun Y, Mei X, Song J, Shi W
Journal of cellular and molecular medicine 2020 Oct;24(20):12164-12175

Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment.

Bertolini I, Ghosh JC, Kossenkov AV, Mulugu S, Krishn SR, Vaira V, Qin J, Plow EF, Languino LR, Altieri DC
Developmental cell 2020 Oct 26;55(2):163-177.e6

miR-124-3p increases in high glucose induced osteocyte-derived exosomes and regulates galectin-3 expression: A possible mechanism in bone remodeling alteration in diabetic periodontitis.

Li J, Guo Y, Chen YY, Liu Q, Chen Y, Tan L, Zhang SH, Gao ZR, Zhou YH, Zhang GY, Feng YZ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):14234-14249

HPV + HNSCC-derived exosomal miR-9 induces macrophage M1 polarization and increases tumor radiosensitivity.

Tong F, Mao X, Zhang S, Xie H, Yan B, Wang B, Sun J, Wei L
Cancer letters 2020 May 28;478:34-44

MSC-derived exosomes attenuate cell death through suppressing AIF nucleus translocation and enhance cutaneous wound healing.

Zhao G, Liu F, Liu Z, Zuo K, Wang B, Zhang Y, Han X, Lian A, Wang Y, Liu M, Zou F, Li P, Liu X, Jin M, Liu JY
Stem cell research & therapy 2020 May 11;11(1):174

Levels of human cytomegalovirus miR-US25-1-5p and miR-UL112-3p in serum extracellular vesicles from infants with HCMV active infection are significantly correlated with liver damage.

Zhang J, Huang Y, Wang Q, Ma Y, Qi Y, Liu Z, Deng J, Ruan Q
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2020 Mar;39(3):471-481

Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity.

Gao M, Dong Z, Sun J, Liu W, Xu M, Li C, Zhu P, Yang X, Shang X, Wu Y, Liu S
Environmental pollution (Barking, Essex : 1987) 2020 Mar;258:113717

Serum exosomal microRNA transcriptome profiling in subacute spinal cord injured rats.

Ding SQ, Chen YQ, Chen J, Wang SN, Duan FX, Shi YJ, Hu JG, Lü HZ
Genomics 2020 Mar;112(2):2092-2105

PTH Derivative promotes wound healing via synergistic multicellular stimulating and exosomal activities.

Shen YF, Huang JH, Wang KY, Zheng J, Cai L, Gao H, Li XL, Li JF
Cell communication and signaling : CCS 2020 Mar 9;18(1):40

The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.

Zheng Y, Zhu G, Yan J, Tang Y, Han S, Yin J, Peng B, He X, Liu W
Journal of virology 2020 Mar 17;94(7)

Host ESCRT factors are recruited during chikungunya virus infection and are required for the intracellular viral replication cycle.

Torii S, Orba Y, Sasaki M, Tabata K, Wada Y, Carr M, Hobson-Peters J, Hall RA, Takada A, Fukuhara T, Matsuura Y, Hall WW, Sawa H
The Journal of biological chemistry 2020 Jun 5;295(23):7941-7957

Design of experiment (DoE)-driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copper-free click chemistry-based labelling.

Xu L, Faruqu FN, Liam-Or R, Abu Abed O, Li D, Venner K, Errington RJ, Summers H, Wang JT, Al-Jamal KT
Journal of extracellular vesicles 2020 Jun 19;9(1):1779458

The protective effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on cisplatin-damaged granulosa cells.

Zhang J, Yin H, Jiang H, Du X, Yang Z
Taiwanese journal of obstetrics & gynecology 2020 Jul;59(4):527-533

Circulating Exosomes From Lipopolysaccharide-Induced Ards Mice Trigger Endoplasmic Reticulum Stress in Lung Tissue.

Tang X, Yu Q, Wen X, Qi D, Peng J, He J, Deng W, Zhu T, Zhao Y, Wang D
Shock (Augusta, Ga.) 2020 Jul;54(1):110-118

Exosomal microRNA-26b-5p down-regulates ATF2 to enhance radiosensitivity of lung adenocarcinoma cells.

Han F, Huang D, Huang X, Wang W, Yang S, Chen S
Journal of cellular and molecular medicine 2020 Jul;24(14):7730-7742

Three-dimensional culture of dental pulp pluripotent-like stem cells (DPPSCs) enhances Nanog expression and provides a serum-free condition for exosome isolation.

Faruqu FN, Zhou S, Sami N, Gheidari F, Lu H, Al-Jamal KT
FASEB bioAdvances 2020 Jul;2(7):419-433

Development of Novel High-Resolution Size-Guided Turbidimetry-Enabled Particle Purification Liquid Chromatography (PPLC): Extracellular Vesicles and Membraneless Condensates in Focus.

Kaddour H, Lyu Y, Shouman N, Mohan M, Okeoma CM
International journal of molecular sciences 2020 Jul 28;21(15)

Extracellular vesicles from human urine-derived stem cells inhibit glucocorticoid-induced osteonecrosis of the femoral head by transporting and releasing pro-angiogenic DMBT1 and anti-apoptotic TIMP1.

Chen CY, Du W, Rao SS, Tan YJ, Hu XK, Luo MJ, Ou QF, Wu PF, Qing LM, Cao ZM, Yin H, Yue T, Zhan CH, Huang J, Zhang Y, Liu YW, Wang ZX, Liu ZZ, Cao J, Liu JH, Hong CG, He ZH, Yang JX, Tang SY, Tang JY, Xie H
Acta biomaterialia 2020 Jul 15;111:208-220

Upregulation of E-cadherin in bronchoalveolar lavage fluid-derived exosomes in patients with lung cancer.

Zhang Y, Liu Z, Li S, Wang M, Dai D, Jing H, Liu L
Thoracic cancer 2020 Jan;11(1):41-47

Beehive-Inspired Macroporous SERS Probe for Cancer Detection through Capturing and Analyzing Exosomes in Plasma.

Dong S, Wang Y, Liu Z, Zhang W, Yi K, Zhang X, Zhang X, Jiang C, Yang S, Wang F, Xiao X
ACS applied materials & interfaces 2020 Jan 29;12(4):5136-5146

Proteomic and lipidomic analysis of exosomes derived from ovarian cancer cells and ovarian surface epithelial cells.

Cheng L, Zhang K, Qing Y, Li D, Cui M, Jin P, Xu T
Journal of ovarian research 2020 Jan 22;13(1):9

SHED-derived conditioned exosomes enhance the osteogenic differentiation of PDLSCs via Wnt and BMP signaling in vitro.

Wang M, Li J, Ye Y, He S, Song J
Differentiation; research in biological diversity 2020 Jan - Feb;111:1-11

Exosomal long noncoding RNA lnc-GNAQ-6:1 may serve as a diagnostic marker for gastric cancer.

Li S, Zhang M, Zhang H, Hu K, Cai C, Wang J, Shi L, Ma P, Xu Y, Zheng P
Clinica chimica acta; international journal of clinical chemistry 2020 Feb;501:252-257

Post-production modifications of murine mesenchymal stem cell (mMSC) derived extracellular vesicles (EVs) and impact on their cellular interaction.

Le Saux S, Aarrass H, Lai-Kee-Him J, Bron P, Armengaud J, Miotello G, Bertrand-Michel J, Dubois E, George S, Faklaris O, Devoisselle JM, Legrand P, Chopineau J, Morille M
Biomaterials 2020 Feb;231:119675

Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway.

Wu X, Wang L, Cong M, Shen M, He Q, Ding F, Shi H
Annals of translational medicine 2020 Dec;8(24):1640

Intratunical injection of human urine-derived stem cells derived exosomes prevents fibrosis and improves erectile function in a rat model of Peyronie's disease.

Yang Q, Chen W, Han D, Zhang C, Xie Y, Sun X, Liu G, Deng C
Andrologia 2020 Dec;52(11):e13831

Circulating exosomal small RNAs are promising non-invasive diagnostic biomarkers for gastric cancer.

Ge L, Zhang N, Li D, Wu Y, Wang H, Wang J
Journal of cellular and molecular medicine 2020 Dec;24(24):14502-14513

Polyethylene Glycol 35 (PEG35) Modulates Exosomal Uptake and Function.

Ferrero-Andrés A, Closa D, Roselló-Catafau J, Folch-Puy E
Polymers 2020 Dec 18;12(12)

Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.

Sha L, Ma D, Chen C
Aging 2020 Dec 13;12(23):23598-23608

Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation.

Mercier V, Larios J, Molinard G, Goujon A, Matile S, Gruenberg J, Roux A
Nature cell biology 2020 Aug;22(8):947-959

Proteomic Analysis Reveals Proteins and Pathways Associated with Lactation in Bovine Mammary Epithelial Cell-Derived Exosomes.

Zhang M, Ma Z, Li R, Guo S, Qiu Y, Gao X
Journal of proteome research 2020 Aug 7;19(8):3211-3219

Hypoxic Tumor-Derived Exosomal Long Noncoding RNA UCA1 Promotes Angiogenesis via miR-96-5p/AMOTL2 in Pancreatic Cancer.

Guo Z, Wang X, Yang Y, Chen W, Zhang K, Teng B, Huang C, Zhao Q, Qiu Z
Molecular therapy. Nucleic acids 2020 Aug 25;22:179-195

Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway.

Yu M, Liu W, Li J, Lu J, Lu H, Jia W, Liu F
Stem cell research & therapy 2020 Aug 12;11(1):350

Long noncoding RNA UCA1 from hypoxia-conditioned hMSC-derived exosomes: a novel molecular target for cardioprotection through miR-873-5p/XIAP axis.

Sun L, Zhu W, Zhao P, Wang Q, Fan B, Zhu Y, Lu Y, Chen Q, Zhang J, Zhang F
Cell death & disease 2020 Aug 10;11(8):696

Adipose-derived exosomes protect the pulmonary endothelial barrier in ventilator-induced lung injury by inhibiting the TRPV4/Ca²⁺ signaling pathway.

Yu Q, Wang D, Wen X, Tang X, Qi D, He J, Zhao Y, Deng W, Zhu T
American journal of physiology. Lung cellular and molecular physiology 2020 Apr 1;318(4):L723-L741

Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation.

Wang D, Hao C, Zhang L, Zhang J, Liu S, Li Y, Qu Y, Zhao Y, Huang R, Wei J, Yao W
Ecotoxicology and environmental safety 2020 Apr 1;192:110253

Bone marrow mesenchymal stem cell-derived exosomes promote tendon regeneration by facilitating the proliferation and migration of endogenous tendon stem/progenitor cells.

Yu H, Cheng J, Shi W, Ren B, Zhao F, Shi Y, Yang P, Duan X, Zhang J, Fu X, Hu X, Ao Y
Acta biomaterialia 2020 Apr 1;106:328-341

Extracellular vesicles expressing a single-chain variable fragment of an HIV-1 specific antibody selectively target Env⁺ tissues.

Zou X, Yuan M, Zhang T, Wei H, Xu S, Jiang N, Zheng N, Wu Z
Theranostics 2019;9(19):5657-5671

Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo.

Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K, Hua W, Zhang Y, Wu X, Yang C
Theranostics 2019;9(14):4084-4100

Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG.

Chen CY, Rao SS, Tan YJ, Luo MJ, Hu XK, Yin H, Huang J, Hu Y, Luo ZW, Liu ZZ, Wang ZX, Cao J, Liu YW, Li HM, Chen Y, Du W, Liu JH, Zhang Y, Chen TH, Liu HM, Wu B, Yue T, Wang YY, Xia K, Lei PF, Tang SY, Xie H
Bone research 2019;7:18

Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting Angiogenesis.

Ding J, Wang X, Chen B, Zhang J, Xu J
BioMed research international 2019;2019:9742765

Serum Exosomal Long Noncoding RNA pcsk2-2:1 As A Potential Novel Diagnostic Biomarker For Gastric Cancer.

Cai C, Zhang H, Zhu Y, Zheng P, Xu Y, Sun J, Zhang M, Lan T, Gu B, Li S, Ma P
OncoTargets and therapy 2019;12:10035-10041

Identification of serum exosomal microRNAs in acute spinal cord injured rats.

Ding SQ, Chen J, Wang SN, Duan FX, Chen YQ, Shi YJ, Hu JG, Lü HZ
Experimental biology and medicine (Maywood, N.J.) 2019 Oct;244(14):1149-1161

Exosome-Mediated MiR-155 Transfer Contributes to Hepatocellular Carcinoma Cell Proliferation by Targeting PTEN.

Sun JF, Zhang D, Gao CJ, Zhang YW, Dai QS
Medical science monitor basic research 2019 Oct 24;25:218-228

Tumor-derived exosomal miRNA-320d as a biomarker for metastatic colorectal cancer.

Tang Y, Zhao Y, Song X, Song X, Niu L, Xie L
Journal of clinical laboratory analysis 2019 Nov;33(9):e23004

Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy.

Essandoh K, Wang X, Huang W, Deng S, Gardner G, Mu X, Li Y, Kranias EG, Wang Y, Fan GC
The Journal of biological chemistry 2019 Nov 29;294(48):18057-18068

Dimethyloxaloylglycine-stimulated human bone marrow mesenchymal stem cell-derived exosomes enhance bone regeneration through angiogenesis by targeting the AKT/mTOR pathway.

Liang B, Liang JM, Ding JN, Xu J, Xu JG, Chai YM
Stem cell research & therapy 2019 Nov 20;10(1):335

Ovarian cancer circulating extracelluar vesicles promote coagulation and have a potential in diagnosis: an iTRAQ based proteomic analysis.

Zhang W, Peng P, Ou X, Shen K, Wu X
BMC cancer 2019 Nov 12;19(1):1095

Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis.

Fan W, Guo J, Gao B, Zhang W, Ling L, Xu T, Pan C, Li L, Chen S, Wang H, Zhang J, Wang X
Science signaling 2019 May 28;12(583)

A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.

Bertolini I, Terrasi A, Martelli C, Gaudioso G, Di Cristofori A, Storaci AM, Formica M, Braidotti P, Todoerti K, Ferrero S, Caroli M, Ottobrini L, Vaccari T, Vaira V
EBioMedicine 2019 Mar;41:225-235

Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.

Yao Z, Jia X, Megger DA, Chen J, Liu Y, Li J, Sitek B, Yuan Z
Journal of proteome research 2019 Mar 1;18(3):855-864

Impaired Bone Regenerative Effect of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells in Type 1 Diabetes.

Zhu Y, Jia Y, Wang Y, Xu J, Chai Y
Stem cells translational medicine 2019 Jun;8(6):593-605

Exosomal cyclophilin A as a novel noninvasive biomarker for Epstein-Barr virus associated nasopharyngeal carcinoma.

Liu L, Zuo L, Yang J, Xin S, Zhang J, Zhou J, Li G, Tang J, Lu J
Cancer medicine 2019 Jun;8(6):3142-3151

The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p.

Wei S, Zheng Y, Jiang Y, Li X, Geng J, Shen Y, Li Q, Wang X, Zhao C, Chen Y, Qian Z, Zhou J, Li W
EBioMedicine 2019 Jun;44:182-193

PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein.

Thura M, Al-Aidaroos AQ, Gupta A, Chee CE, Lee SC, Hui KM, Li J, Guan YK, Yong WP, So J, Chng WJ, Ng CH, Zhou J, Wang LZ, Yuen JSP, Ho HSS, Yi SM, Chiong E, Choo SP, Ngeow J, Ng MCH, Chua C, Yeo ESA, Tan IBH, Sng JXE, Tan NYZ, Thiery JP, Goh BC, Zeng Q
Nature communications 2019 Jun 6;10(1):2484

A Septin Double Ring Controls the Spatiotemporal Organization of the ESCRT Machinery in Cytokinetic Abscission.

Karasmanis EP, Hwang D, Nakos K, Bowen JR, Angelis D, Spiliotis ET
Current biology : CB 2019 Jul 8;29(13):2174-2182.e7

Exosomes of stem cells from human exfoliated deciduous teeth as an anti-inflammatory agent in temporomandibular joint chondrocytes via miR-100-5p/mTOR.

Luo P, Jiang C, Ji P, Wang M, Xu J
Stem cell research & therapy 2019 Jul 29;10(1):216

Exosomal miR-1229 derived from colorectal cancer cells promotes angiogenesis by targeting HIPK2.

Hu HY, Yu CH, Zhang HH, Zhang SZ, Yu WY, Yang Y, Chen Q
International journal of biological macromolecules 2019 Jul 1;132:470-477

A novel strategy for facile serum exosome isolation based on specific interactions between phospholipid bilayers and TiO(2).

Gao F, Jiao F, Xia C, Zhao Y, Ying W, Xie Y, Guan X, Tao M, Zhang Y, Qin W, Qian X
Chemical science 2019 Feb 14;10(6):1579-1588

Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer.

Hu Y, Qi C, Liu X, Zhang C, Gao J, Wu Y, Yang J, Zhao Q, Li J, Wang X, Shen L
Cancer letters 2019 Aug 10;457:142-150

Exosomes from hypoxia-treated human adipose-derived mesenchymal stem cells enhance angiogenesis through VEGF/VEGF-R.

Han Y, Ren J, Bai Y, Pei X, Han Y
The international journal of biochemistry & cell biology 2019 Apr;109:59-68

Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α₁-antitrypsin disposal.

Khodayari N, Oshins R, Alli AA, Tuna KM, Holliday LS, Krotova K, Brantly M
The Journal of biological chemistry 2019 Apr 19;294(16):6240-6252

Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway.

Wang S, Su X, Xu M, Xiao X, Li X, Li H, Keating A, Zhao RC
Stem cell research & therapy 2019 Apr 11;10(1):117

Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis.

Chen CY, Rao SS, Ren L, Hu XK, Tan YJ, Hu Y, Luo J, Liu YW, Yin H, Huang J, Cao J, Wang ZX, Liu ZZ, Liu HM, Tang SY, Xu R, Xie H
Theranostics 2018;8(6):1607-1623

Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function.

Hu Y, Rao SS, Wang ZX, Cao J, Tan YJ, Luo J, Li HM, Zhang WS, Chen CY, Xie H
Theranostics 2018;8(1):169-184

Characterization and selective incorporation of small non-coding RNAs in non-small cell lung cancer extracellular vesicles.

Li C, Qin F, Hu F, Xu H, Sun G, Han G, Wang T, Guo M
Cell & bioscience 2018;8:2

Tumor-Derived Exosomal Long Noncoding RNAs as Promising Diagnostic Biomarkers for Prostate Cancer.

Wang YH, Ji J, Wang BC, Chen H, Yang ZH, Wang K, Luo CL, Zhang WW, Wang FB, Zhang XL
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(2):532-545

Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding.

Huang H, Zheng X, Cai C, Yao Z, Lu S, Meng X, Miao Y, He Z, Cai C, Zou F
Biochemical and biophysical research communications 2018 Sep 3;503(1):242-248

Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway.

Zhou X, Yan T, Huang C, Xu Z, Wang L, Jiang E, Wang H, Chen Y, Liu K, Shao Z, Shang Z
Journal of experimental & clinical cancer research : CR 2018 Oct 3;37(1):242

mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3.

Shi G, Ozog S, Torbett BE, Compton AA
Proceedings of the National Academy of Sciences of the United States of America 2018 Oct 23;115(43):E10069-E10078

Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury.

Bai Y, Han YD, Yan XL, Ren J, Zeng Q, Li XD, Pei XT, Han Y
Biochemical and biophysical research communications 2018 Jun 2;500(2):310-317

Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.

Zhao H, Shang Q, Pan Z, Bai Y, Li Z, Zhang H, Zhang Q, Guo C, Zhang L, Wang Q
Diabetes 2018 Feb;67(2):235-247

Co-transplantation of exosomes derived from hypoxia-preconditioned adipose mesenchymal stem cells promotes neovascularization and graft survival in fat grafting.

Han YD, Bai Y, Yan XL, Ren J, Zeng Q, Li XD, Pei XT, Han Y
Biochemical and biophysical research communications 2018 Feb 26;497(1):305-312

Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity.

Yao Z, Qiao Y, Li X, Chen J, Ding J, Bai L, Shen F, Shi B, Liu J, Peng L, Li J, Yuan Z
Journal of virology 2018 Dec 15;92(24)

Circulating Exosomal miR-17-5p and miR-92a-3p Predict Pathologic Stage and Grade of Colorectal Cancer.

Fu F, Jiang W, Zhou L, Chen Z
Translational oncology 2018 Apr;11(2):221-232

Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection.

Fu Y, Zhang L, Zhang F, Tang T, Zhou Q, Feng C, Jin Y, Wu Z
PLoS pathogens 2017 Sep;13(9):e1006611

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, Takasugi M, Watanabe S, Kanemaki MT, Obuse C, Hara E
Nature communications 2017 May 16;8:15287

Prions amplify through degradation of the VPS10P sorting receptor sortilin.

Uchiyama K, Tomita M, Yano M, Chida J, Hara H, Das NR, Nykjaer A, Sakaguchi S
PLoS pathogens 2017 Jun;13(6):e1006470

REG3β modifies cell tumor function by impairing extracellular vesicle uptake.

Bonjoch L, Gironella M, Iovanna JL, Closa D
Scientific reports 2017 Jun 9;7(1):3143

Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer.

Nabet BY, Qiu Y, Shabason JE, Wu TJ, Yoon T, Kim BC, Benci JL, DeMichele AM, Tchou J, Marcotrigiano J, Minn AJ
Cell 2017 Jul 13;170(2):352-366.e13

Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line.

Jia X, Chen J, Megger DA, Zhang X, Kozlowski M, Zhang L, Fang Z, Li J, Chu Q, Wu M, Li Y, Sitek B, Yuan Z
Molecular & cellular proteomics : MCP 2017 Apr;16(4 suppl 1):S144-S160

Involvement of exosomes in lung inflammation associated with experimental acute pancreatitis.

Bonjoch L, Casas V, Carrascal M, Closa D
The Journal of pathology 2016 Oct;240(2):235-45

ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus.

Kumar B, Dutta D, Iqbal J, Ansari MA, Roy A, Chikoti L, Pisano G, Veettil MV, Chandran B
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Regulation of exosomes released from normal ovarian epithelial cells and ovarian cancer cells.

Zhang W, Yang J, Cao D, You Y, Shen K, Peng P
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Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.

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Charcot-Marie-Tooth disease type 2G redefined by a novel mutation in LRSAM1.

Peeters K, Palaima P, Pelayo-Negro AL, García A, Gallardo E, García-Barredo R, Mateiu L, Baets J, Menten B, De Vriendt E, De Jonghe P, Timmerman V, Infante J, Berciano J, Jordanova A
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Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer.

Wang X, Xu C, Hua Y, Sun L, Cheng K, Jia Z, Han Y, Dong J, Cui Y, Yang Z
Journal of experimental & clinical cancer research : CR 2016 Dec 1;35(1):186

High LIN28A Expressing Ovarian Cancer Cells Secrete Exosomes That Induce Invasion and Migration in HEK293 Cells.

Enriquez VA, Cleys ER, Da Silveira JC, Spillman MA, Winger QA, Bouma GJ
BioMed research international 2015;2015:701390

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth.

Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, Li P, Li M, Wang X, Zhang C, Wang H, Ellis K, Cheerathodi M, McCarty JH, Palmieri D, Saunus J, Lakhani S, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D
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Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways.

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Journal of proteomics 2013 Mar 27;80:171-82

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.

Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, Yuan Z
Nature immunology 2013 Aug;14(8):793-803

Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer.

Dayan D, Salo T, Salo S, Nyberg P, Nurmenniemi S, Costea DE, Vered M
Cancer medicine 2012 Oct;1(2):128-40

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 14497-1-AP(TSG101 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using TSG101 antibody 14497-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-TSG101 (IP:14497-1-AP, 3ug; Detection:14497-1-AP 1:500) with HeLa cells lysate 1320ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human heart using 14497-1-AP(TSG101 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human heart using 14497-1-AP(TSG101 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue