FNab07244

antibody from FineTest Biotech

Targeting: REST DFNA27, NRSF, XBR

Western blot

ELISA

Immunoprecipitation

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Validation data

Product number: FNab07244 - Provider product page
Provider: FineTest Biotech
Product name: REST antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: Transcriptional repressor which binds neuron-restrictive silencer element(NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.
Reactivity: Human, Rat
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: RE1-silencing transcription factor
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

REST protein structure - FNab07244 shown in red.