Tissue expression
Cell line expression
Protein structure
PICALM
Phosphatidylinositol binding clathrin assembly proteinCALM, CLTH
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Top validated antibodies |
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Atlas Antibodies | HPA019061 | 2 references | Polyclonal |
WB
IHC |
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Boster Biological Technology | A02053-1 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Biorbyt | orb623882 | Polyclonal |
WB
EL
ICC
IHC
FC
|
||
Invitrogen Antibodies | PA5-82659 | Polyclonal |
WB
ICC
IHC
OA |
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GeneTex | GTX85213 | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
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Recommended by provider