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LearnABIN151887
antibody from antibodies-online
Targeting: HIF1AN
DKFZp762F1811, FIH1, FLJ20615, FLJ22027
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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [21]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN151887 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN) (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- C-Term
- Vial size
- 0.1 mL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1.
NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells.
Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival.
Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.
Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2).
Increased activation of the hypoxia-inducible factor pathway in varicose veins.
Factor inhibiting HIF (FIH) recognizes distinct molecular features within hypoxia-inducible factor-α (HIF-α) versus ankyrin repeat substrates.
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.
Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.
The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH.
Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells.
Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis.
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.
The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux.
Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J, Semenza GL
Science signaling 2016 May 31;9(430):ra56
Science signaling 2016 May 31;9(430):ra56
NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells.
Nakaoka HJ, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, Sato H, Murakami Y, Seiki M, Sakamoto T
Scientific reports 2016 Mar 7;6:22784
Scientific reports 2016 Mar 7;6:22784
Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival.
Kiriakidis S, Henze AT, Kruszynska-Ziaja I, Skobridis K, Theodorou V, Paleolog EM, Mazzone M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jul;29(7):2814-27
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jul;29(7):2814-27
Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.
Karttunen S, Duffield M, Scrimgeour NR, Squires L, Lim WL, Dallas ML, Scragg JL, Chicher J, Dave KA, Whitelaw ML, Peers C, Gorman JJ, Gleadle JM, Rychkov GY, Peet DJ
Journal of cell science 2015 Jan 15;128(2):225-31
Journal of cell science 2015 Jan 15;128(2):225-31
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.
Rawluszko AA, Bujnicka KE, Horbacka K, Krokowicz P, Jagodziński PP
BMC cancer 2013 Nov 6;13:526
BMC cancer 2013 Nov 6;13:526
Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2).
Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbäurl H, Metzen E
Journal of cell science 2013 Jun 15;126(Pt 12):2629-40
Journal of cell science 2013 Jun 15;126(Pt 12):2629-40
Increased activation of the hypoxia-inducible factor pathway in varicose veins.
Lim CS, Kiriakidis S, Paleolog EM, Davies AH
Journal of vascular surgery 2012 May;55(5):1427-39
Journal of vascular surgery 2012 May;55(5):1427-39
Factor inhibiting HIF (FIH) recognizes distinct molecular features within hypoxia-inducible factor-α (HIF-α) versus ankyrin repeat substrates.
Wilkins SE, Karttunen S, Hampton-Smith RJ, Murchland I, Chapman-Smith A, Peet DJ
The Journal of biological chemistry 2012 Mar 16;287(12):8769-81
The Journal of biological chemistry 2012 Mar 16;287(12):8769-81
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.
Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K
Blood 2012 Jun 7;119(23):5405-16
Blood 2012 Jun 7;119(23):5405-16
Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.
Singleton RS, Trudgian DC, Fischer R, Kessler BM, Ratcliffe PJ, Cockman ME
The Journal of biological chemistry 2011 Sep 30;286(39):33784-94
The Journal of biological chemistry 2011 Sep 30;286(39):33784-94
The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH.
Melvin A, Mudie S, Rocha S
Molecular biology of the cell 2011 Nov;22(21):4171-81
Molecular biology of the cell 2011 Nov;22(21):4171-81
Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells.
Schödel J, Bohr D, Klanke B, Schley G, Schlötzer-Schrehardt U, Warnecke C, Kurtz A, Amann K, Eckardt KU, Willam C
Kidney international 2010 Nov;78(9):857-67
Kidney international 2010 Nov;78(9):857-67
Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis.
Luo T, Zhang X, Nicholson WL, Zhu B, McBride JW
Clinical and vaccine immunology : CVI 2010 Jan;17(1):87-97
Clinical and vaccine immunology : CVI 2010 Jan;17(1):87-97
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG Jr
Molecular and cellular biology 2009 Nov;29(21):5729-41
Molecular and cellular biology 2009 Nov;29(21):5729-41
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ
Cancer cell 2009 Jun 2;15(6):527-38
Cancer cell 2009 Jun 2;15(6):527-38
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.
Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, Hamilton BR, Gustafsson M, Ruas JL, Wilkins S, Bilton RL, Brismar K, Whitelaw ML, Pereira T, Gorman JJ, Ericson J, Peet DJ, Lendahl U, Poellinger L
Proceedings of the National Academy of Sciences of the United States of America 2008 Mar 4;105(9):3368-73
Proceedings of the National Academy of Sciences of the United States of America 2008 Mar 4;105(9):3368-73
The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.
Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D
Molecular and cellular biology 2008 Dec;28(24):7345-53
Molecular and cellular biology 2008 Dec;28(24):7345-53
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
Ferguson JE 3rd, Wu Y, Smith K, Charles P, Powers K, Wang H, Patterson C
Molecular and cellular biology 2007 Sep;27(18):6407-19
Molecular and cellular biology 2007 Sep;27(18):6407-19
Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux.
Li J, Wang E, Dutta S, Lau JS, Jiang SW, Datta K, Mukhopadhyay D
Molecular and cellular biology 2007 Oct;27(20):7345-53
Molecular and cellular biology 2007 Oct;27(20):7345-53
Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.
Birle DC, Hedley DW
Cancer research 2007 Feb 15;67(4):1735-43
Cancer research 2007 Feb 15;67(4):1735-43
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Khan Z, Michalopoulos GK, Stolz DB
The American journal of pathology 2006 Oct;169(4):1251-69
The American journal of pathology 2006 Oct;169(4):1251-69
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
