NB100-428

Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML, Bix M
PloS one 2019;14(2):e0211244

Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1.

Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J, Semenza GL
Science signaling 2016 May 31;9(430):ra56

NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells.

Nakaoka HJ, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, Sato H, Murakami Y, Seiki M, Sakamoto T
Scientific reports 2016 Mar 7;6:22784

Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival.

Kiriakidis S, Henze AT, Kruszynska-Ziaja I, Skobridis K, Theodorou V, Paleolog EM, Mazzone M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jul;29(7):2814-27

Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.

Karttunen S, Duffield M, Scrimgeour NR, Squires L, Lim WL, Dallas ML, Scragg JL, Chicher J, Dave KA, Whitelaw ML, Peers C, Gorman JJ, Gleadle JM, Rychkov GY, Peet DJ
Journal of cell science 2015 Jan 15;128(2):225-31

Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.

Rawluszko AA, Bujnicka KE, Horbacka K, Krokowicz P, Jagodziński PP
BMC cancer 2013 Nov 6;13:526

Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2).

Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbäurl H, Metzen E
Journal of cell science 2013 Jun 15;126(Pt 12):2629-40

Increased activation of the hypoxia-inducible factor pathway in varicose veins.

Lim CS, Kiriakidis S, Paleolog EM, Davies AH
Journal of vascular surgery 2012 May;55(5):1427-39

Factor inhibiting HIF (FIH) recognizes distinct molecular features within hypoxia-inducible factor-α (HIF-α) versus ankyrin repeat substrates.

Wilkins SE, Karttunen S, Hampton-Smith RJ, Murchland I, Chapman-Smith A, Peet DJ
The Journal of biological chemistry 2012 Mar 16;287(12):8769-81

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.

Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K
Blood 2012 Jun 7;119(23):5405-16

Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.

Singleton RS, Trudgian DC, Fischer R, Kessler BM, Ratcliffe PJ, Cockman ME
The Journal of biological chemistry 2011 Sep 30;286(39):33784-94

The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH.

Melvin A, Mudie S, Rocha S
Molecular biology of the cell 2011 Nov;22(21):4171-81

Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells.

Schödel J, Bohr D, Klanke B, Schley G, Schlötzer-Schrehardt U, Warnecke C, Kurtz A, Amann K, Eckardt KU, Willam C
Kidney international 2010 Nov;78(9):857-67

Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis.

Luo T, Zhang X, Nicholson WL, Zhu B, McBride JW
Clinical and vaccine immunology : CVI 2010 Jan;17(1):87-97

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.

Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG Jr
Molecular and cellular biology 2009 Nov;29(21):5729-41

Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.

Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ
Cancer cell 2009 Jun 2;15(6):527-38

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, Hamilton BR, Gustafsson M, Ruas JL, Wilkins S, Bilton RL, Brismar K, Whitelaw ML, Pereira T, Gorman JJ, Ericson J, Peet DJ, Lendahl U, Poellinger L
Proceedings of the National Academy of Sciences of the United States of America 2008 Mar 4;105(9):3368-73

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D
Molecular and cellular biology 2008 Dec;28(24):7345-53

ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.

Ferguson JE 3rd, Wu Y, Smith K, Charles P, Powers K, Wang H, Patterson C
Molecular and cellular biology 2007 Sep;27(18):6407-19

Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux.

Li J, Wang E, Dutta S, Lau JS, Jiang SW, Datta K, Mukhopadhyay D
Molecular and cellular biology 2007 Oct;27(20):7345-53

Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.

Khan Z, Michalopoulos GK, Stolz DB
The American journal of pathology 2006 Oct;169(4):1251-69

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: FIH-1/HIF-1AN Antibody [NB100-428] - Analysis of astrocytes lysate from Rat brain using FIH-1/HIF-1AN antibody at 1:500 dilution with ECL detection. The antibody detected a major band at ~40 kDa position representing FIH-1/HIF-1AN protein.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: FIH-1/HIF-1AN Antibody [NB100-428] - Rat VSMC (vascular smoot muscle) cells treated (siFIH) or not (CTL) with a specific siRNA against FIH-1. Western blot image submitted by a verified customer review.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry: FIH-1/HIF-1AN Antibody [NB100-428] - Detection of FIH-1 in rat brain tissue.