BS7878

antibody from Bioworld Technology, Inc
Targeting: HTATIP2 CC3, FLJ26963, SDR44U1, TIP30
Provider product page for BS7878
Western blot
Immunohistochemistry

Antibody data

Product number
BS7878 - Provider product page
Provider
Bioworld Technology, Inc
Product name
HTATIP2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human HTATIP2.
Description
TIP30 (30 kDa HIV-1 TAT-interacting protein), also known as HTATIP2 (HIV-1 TAT-interactive protein 2) or CC3, is a ubiquitously expressed protein that functions as an oxidoreductase. It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induction of apoptosis. TIP30 interacts with the ERÏ«-interacting coactivator NCoA-5 and functions to regulate liganded and unliganded ERÏ«-mediated c-Myc transcription. More specifically, when overexpressed TIP30 represses c-Myc transcription mediated by ERÏ«, while the deficiency of TIP30 leads to an increase in c-Myc transcription. In addition, TIP30 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in TIP30 are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for TIP30 in antitumor therapy.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
HTATIP2 protein structure - BS7878 shown in red.