CABT-B9228

antibody from Creative Diagnostics

Targeting: KPNB1 IMB1, Impnb, IPO1, IPOB, MGC2155, MGC2156, MGC2157, NTF97

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9228

Provider

Creative Diagnostics

Product name

Mouse anti-Rat Karyopherin beta monoclonal antibody, clone 34

Antibody type

Monoclonal

Description

Using nuclear import assays, several cytosolic proteins that form a multi-protein complex have been identified. These proteins of 54 kDa, 56 kDa, and 97 kDa stimulate the nuclear transport of proteins containing a nuclear localization signal (NLS). The 97 kDa protein has been named karyopherin ÉÇ. The NLS binds to karyopherin Ï«. Binding is enhanced by karyopherin ÉÇ. The NLS substrate also binds to the N-terminal region of karyopherin ÉÇ. Both karyopherins bind to repeat sequences of nucleoporins at the nuclear envelope. Once the substrate is docked to the nuclear envelope, Ran hydrolyzes GTP and translocation occurs. Karyopherin ÉÇ also binds to and inhibits the Ran GTPase protein, thus providing a mechanism of nuclear transport termination.

Reactivity

Human, Mouse, Rat, Canine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

34

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.