CABT-B9228

KPNB1 antibody from Creative Diagnostics
IMB1, Impnb, IPO1, IPOB, MGC2155, MGC2156, MGC2157, NTF97
Western blot
Recommended by provider
Immunocytochemistry
Recommended by provider
Immunoprecipitation
Recommended by provider
Immunohistochemistry
Recommended by provider

Antibody data

Product number
CABT-B9228
Provider
Creative Diagnostics
Product name
Mouse anti-Rat Karyopherin beta monoclonal antibody, clone 34
Provider product page
Creative Diagnostics - CABT-B9228
Antibody type
Monoclonal
Description
Using nuclear import assays, several cytosolic proteins that form a multi-protein complex have been identified. These proteins of 54 kDa, 56 kDa, and 97 kDa stimulate the nuclear transport of proteins containing a nuclear localization signal (NLS). The 97 kDa protein has been named karyopherin ÉÇ. The NLS binds to karyopherin Ï«. Binding is enhanced by karyopherin ÉÇ. The NLS substrate also binds to the N-terminal region of karyopherin ÉÇ. Both karyopherins bind to repeat sequences of nucleoporins at the nuclear envelope. Once the substrate is docked to the nuclear envelope, Ran hydrolyzes GTP and translocation occurs. Karyopherin ÉÇ also binds to and inhibits the Ran GTPase protein, thus providing a mechanism of nuclear transport termination.
Reactivity
Human, Mouse, Rat, Canine
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
34
Vial size
50ug, 150ug
Concentration
250 Ã×g/ml
Storage
Store undiluted at -20°C.
Provider Type Product Number
- No reagents -