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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- PP-A9033A-00 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal FXR/NR1H4 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. This antibody specifically recognizes human FXR and cross-reacts with rat and mouse FXR. Not yet tested in other species.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Storage
- This antibody is stable for greater than six months when held at -20 degreesC in a manual defrost freezer or at -70 degreesC. Upon thawing, the antibody can be stored at 2-8 degreesC for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Submitted references FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.
Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways.
Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein.
Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage.
Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion.
Deuschle U, Schüler J, Schulz A, Schlüter T, Kinzel O, Abel U, Kremoser C
PloS one 2012;7(10):e43044
PloS one 2012;7(10):e43044
Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways.
Bhargava P, Li C, Stanya KJ, Jacobi D, Dai L, Liu S, Gangl MR, Harn DA, Lee CH
Nature medicine 2012 Nov;18(11):1665-72
Nature medicine 2012 Nov;18(11):1665-72
Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein.
Prade E, Tobiasch M, Hitkova I, Schäffer I, Lian F, Xing X, Tänzer M, Rauser S, Walch A, Feith M, Post S, Röcken C, Schmid RM, Ebert MP, Burgermeister E
Molecular endocrinology (Baltimore, Md.) 2012 May;26(5):819-32
Molecular endocrinology (Baltimore, Md.) 2012 May;26(5):819-32
Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage.
Lian F, Xing X, Yuan G, Schäfer C, Rauser S, Walch A, Röcken C, Ebeling M, Wright MB, Schmid RM, Ebert MP, Burgermeister E
The Biochemical journal 2011 Sep 1;438(2):315-23
The Biochemical journal 2011 Sep 1;438(2):315-23
Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion.
Lee JY, Lee KT, Lee JK, Lee KH, Jang KT, Heo JS, Choi SH, Kim Y, Rhee JC
British journal of cancer 2011 Mar 15;104(6):1027-37
British journal of cancer 2011 Mar 15;104(6):1027-37
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