PP-A9033A-00

antibody from R&D Systems

Targeting: NR1H4 FXR, HRR-1, HRR1, RIP14

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

PP-A9033A-00

Provider

R&D Systems

Product name

Human FXR/NR1H4 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. This antibody specifically recognizes human FXR and cross-reacts with rat and mouse FXR. Not yet tested in other species.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

A9033A

Vial size

100 ug

Storage

This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

References

Submitted references

FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.

Deuschle U, Schüler J, Schulz A, Schlüter T, Kinzel O, Abel U, Kremoser C
PloS one 2012;7(10):e43044

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Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways.

Bhargava P, Li C, Stanya KJ, Jacobi D, Dai L, Liu S, Gangl MR, Harn DA, Lee CH
Nature medicine 2012 Nov;18(11):1665-72

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Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein.

Prade E, Tobiasch M, Hitkova I, Schäffer I, Lian F, Xing X, Tänzer M, Rauser S, Walch A, Feith M, Post S, Röcken C, Schmid RM, Ebert MP, Burgermeister E
Molecular endocrinology (Baltimore, Md.) 2012 May;26(5):819-32

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Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage.

Lian F, Xing X, Yuan G, Schäfer C, Rauser S, Walch A, Röcken C, Ebeling M, Wright MB, Schmid RM, Ebert MP, Burgermeister E
The Biochemical journal 2011 Sep 1;438(2):315-23

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Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion.

Lee JY, Lee KT, Lee JK, Lee KH, Jang KT, Heo JS, Choi SH, Kim Y, Rhee JC
British journal of cancer 2011 Mar 15;104(6):1027-37