BS7970

antibody from Bioworld Technology, Inc
Targeting: CBX4 hPC2, NBP16, PC2
Provider product page for BS7970
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7970 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CBX4 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CBX4.
Description
Polycomb group (PcG) proteins form multiprotein complexes and play a role in gene silencing and Hox gene regulation by altering chromatin structure during transcription. The PcG protein MPc2, also known as CBX4, PC2 or HPc2, maps to human chromosome 17q25.3. MPc2 and MPc3 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1. MPc2 is a repressor of proto-oncogene activity, thus interference with MPc2 function can lead to depression of proto-oncogene transcription and subsequently to cellular transformation. MPc2 is able to act as a long range transcriptional silencer. MPc2 is expressed in the human osteosarcoma cell line U-20S. MPc2 is part of a large multiprotein complex that also contains other PcG proteins including Bmi-1.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CBX4 protein structure - BS7970 shown in red.