BS6887

antibody from Bioworld Technology, Inc
Targeting: HDAC2 KDAC2, RPD3, YAF1
Provider product page for BS6887
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6887 - Provider product page
Provider
Bioworld Technology, Inc
Product name
HDAC2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human HDAC2.
Description
The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription. HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes. In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity. Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases. Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
HDAC2 protein structure - BS6887 shown in red.