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- Antibody Data
- Antigen structure
- References [45]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 10727-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10727-1-AP, RRID:AB_2278673
- Product name
- Ferritin light chain antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Ferritin light chain antibody (Cat. #10727-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Resistance to disuse-induced iron overload in Daurian ground squirrels (Spermophilus dauricus) during extended hibernation inactivity.
Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice.
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Oxalate Activates Autophagy to Induce Ferroptosis of Renal Tubular Epithelial Cells and Participates in the Formation of Kidney Stones.
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells.
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats.
Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14.
Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1α/MAPK Pathway in the Liver.
Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements.
Juxtacortical susceptibility changes in progressive multifocal leukoencephalopathy at the gray-white matter junction correlates with iron-enriched macrophages.
Lysosome Fe2+ release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells.
Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice.
Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31.
Identification and initial characterization of a potent inhibitor of ferroptosis.
GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis.
Cyclophosphamide induces a significant increase in iron content in the liver and spleen of mice.
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Angiotensin II down-regulates transferrin receptor 1 and ferroportin 1 expression in Neuro-2a cells via activation of type-1 receptor.
Identification of differentially expressed proteins associated with recurrence in ovarian endometriotic cysts.
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Regulating ferroportin-1 and transferrin receptor-1 expression: A novel function of hydrogen sulfide.
Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess.
Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease.
Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation.
Fasting up-regulates ferroportin 1 expression via a Ghrelin/GHSR/MAPK signaling pathway.
Aspirin increases ferroportin 1 expression by inhibiting hepcidin via the JAK/STAT3 pathway in interleukin 6-treated PC-12 cells.
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Different Characteristics of Hepcidin Expression in IL-6+/+ and IL-6-/- Neurons and Astrocytes Treated with Lipopolysaccharides.
Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.
Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis.
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells.
Digital gene expression profiling analysis of duodenum transcriptomes in SD rats administered ferrous sulfate or ferrous glycine chelate by gavage.
Nuclear transcription factor Nrf2 suppresses prostate cancer cells growth and migration through upregulating ferroportin.
Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure.
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Effects of aspirin on expression of iron transport and storage proteins in BV-2 microglial cells.
Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Iron and neurodegeneration in the multiple sclerosis brain.
Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.
Yin R, Zhang J, Xu S, Kong Y, Wang H, Gao Y
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2022 Jan;257:110650
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2022 Jan;257:110650
Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice.
Zhang F, Zhao P, Qian Z, Zhong M
Frontiers in nutrition 2021;8:649640
Frontiers in nutrition 2021;8:649640
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Lu S, Song Y, Luo R, Li S, Li G, Wang K, Liao Z, Wang B, Ke W, Xiang Q, Chen C, Wu X, Zhang Y, Ling L, Yang C
Oxidative medicine and cellular longevity 2021;2021:6670497
Oxidative medicine and cellular longevity 2021;2021:6670497
Oxalate Activates Autophagy to Induce Ferroptosis of Renal Tubular Epithelial Cells and Participates in the Formation of Kidney Stones.
Song Q, Liao W, Chen X, He Z, Li, Li B, Liu J, Liu L, Xiong Y, Song C, Yang S
Oxidative medicine and cellular longevity 2021;2021:6630343
Oxidative medicine and cellular longevity 2021;2021:6630343
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
Zhang Y, Guo S, Wang S, Li X, Hou D, Li H, Wang L, Xu Y, Ma B, Wang H, Jiang X
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells.
He Y, Fang D, Liang T, Pang H, Nong Y, Tang L, Yang Z, Lu C, Han X, Zhao S, Mo S, Meng Y, Han C, Peng T
Annals of translational medicine 2021 Oct;9(20):1535
Annals of translational medicine 2021 Oct;9(20):1535
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.
Wang L, Ouyang S, Li B, Wu H, Wang F
Cell death discovery 2021 Nov 3;7(1):334
Cell death discovery 2021 Nov 3;7(1):334
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.
Yan PJ, Ren ZX, Shi ZF, Wan CL, Han CJ, Zhu LS, Li NN, Waddington JL, Zhen XC
Acta pharmacologica Sinica 2021 Nov 22;
Acta pharmacologica Sinica 2021 Nov 22;
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats.
Yang G, Qian C, Zhang C, Bao Y, Liu MY, Jiang F, Li W, Liu Y, Ke Y, Qian ZM
Translational research : the journal of laboratory and clinical medicine 2021 Mar;229:53-68
Translational research : the journal of laboratory and clinical medicine 2021 Mar;229:53-68
Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14.
Prajapati M, Conboy HL, Hojyo S, Fukada T, Budnik B, Bartnikas TB
The Journal of biological chemistry 2021 Jul;297(1):100835
The Journal of biological chemistry 2021 Jul;297(1):100835
Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1α/MAPK Pathway in the Liver.
Luo Q, Hu J, Yang G, Yuan X, Chen Z, Wang D, Lu Y, Zhu L, Wang G
Biological trace element research 2021 Jan;199(1):267-277
Biological trace element research 2021 Jan;199(1):267-277
Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements.
Zhang Q, Lu XM, Zhang M, Yang CY, Lv SY, Li SF, Zhong CY, Geng SS
Scientific reports 2021 Jan 14;11(1):1347
Scientific reports 2021 Jan 14;11(1):1347
Juxtacortical susceptibility changes in progressive multifocal leukoencephalopathy at the gray-white matter junction correlates with iron-enriched macrophages.
Mahajan KR, Amin M, Poturalski M, Lee J, Herman D, Zheng Y, Androjna C, Howell M, Fox RJ, Trapp BD, Jones SE, Nakamura K, Ontaneda D
Multiple sclerosis (Houndmills, Basingstoke, England) 2021 Dec;27(14):2159-2169
Multiple sclerosis (Houndmills, Basingstoke, England) 2021 Dec;27(14):2159-2169
Lysosome Fe2+ release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells.
Wang K, Chen X, Zuyi W, Chen L, Fu W
Environmental toxicology 2021 Aug;36(8):1654-1663
Environmental toxicology 2021 Aug;36(8):1654-1663
Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice.
Ma J, Qian C, Bao Y, Liu MY, Ma HM, Shen MQ, Li W, Wang JJ, Bao YX, Liu Y, Ke Y, Qian ZM
Redox biology 2021 Apr;40:101865
Redox biology 2021 Apr;40:101865
Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31.
Simmons DA, Mills BD, Butler Iii RR, Kuan J, McHugh TLM, Akers C, Zhou J, Syriani W, Grouban M, Zeineh M, Longo FM
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Apr;18(2):1039-1063
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Apr;18(2):1039-1063
Identification and initial characterization of a potent inhibitor of ferroptosis.
Kuganesan N, Dlamini S, McDaniel J, Tillekeratne VLM, Taylor WR
Journal of cellular biochemistry 2021 Apr;122(3-4):413-424
Journal of cellular biochemistry 2021 Apr;122(3-4):413-424
GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis.
Wang Q, Bin C, Xue Q, Gao Q, Huang A, Wang K, Tang N
Cell death & disease 2021 Apr 30;12(5):426
Cell death & disease 2021 Apr 30;12(5):426
Cyclophosphamide induces a significant increase in iron content in the liver and spleen of mice.
Sheng Y, Chen YJ, Qian ZM, Zheng J, Liu Y
Human & experimental toxicology 2020 Jul;39(7):973-983
Human & experimental toxicology 2020 Jul;39(7):973-983
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Wang J, Deng B, Liu Q, Huang Y, Chen W, Li J, Zhou Z, Zhang L, Liang B, He J, Chen Z, Yan C, Yang Z, Xian S, Wang L
Cell death & disease 2020 Jul 24;11(7):574
Cell death & disease 2020 Jul 24;11(7):574
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Feng Q, Bian X, Liu X, Wang Y, Zhou H, Ma X, Quan C, Yao Y, Zheng Z
BMC cancer 2020 Jul 16;20(1):665
BMC cancer 2020 Jul 16;20(1):665
Angiotensin II down-regulates transferrin receptor 1 and ferroportin 1 expression in Neuro-2a cells via activation of type-1 receptor.
Chen YJ, Qian ZM, Sheng Y, Zheng J, Liu Y
Neuroscience letters 2020 Jan 18;716:134684
Neuroscience letters 2020 Jan 18;716:134684
Identification of differentially expressed proteins associated with recurrence in ovarian endometriotic cysts.
Zhu G, Kong J, Fu X, Liu F, Huang H, Hong L, Wang K
Systems biology in reproductive medicine 2020 Feb;66(1):59-69
Systems biology in reproductive medicine 2020 Feb;66(1):59-69
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Li S, Qian ZM, Xu G, Zheng J, Wu Y
Bioscience reports 2020 Apr 30;40(4)
Bioscience reports 2020 Apr 30;40(4)
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329
Metabolic brain disease 2019 Feb;34(1):319-329
Regulating ferroportin-1 and transferrin receptor-1 expression: A novel function of hydrogen sulfide.
Zhang MW, Yang G, Zhou YF, Qian C, Mu MD, Ke Y, Qian ZM
Journal of cellular physiology 2019 Apr;234(4):3158-3169
Journal of cellular physiology 2019 Apr;234(4):3158-3169
Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess.
Mercadante CJ, Prajapati M, Parmar JH, Conboy HL, Dash ME, Pettiglio MA, Herrera C, Bu JT, Stopa EG, Mendes P, Bartnikas TB
Haematologica 2019 Apr;104(4):678-689
Haematologica 2019 Apr;104(4):678-689
Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease.
Niu L, Ye C, Sun Y, Peng T, Yang S, Wang W, Li H
Cell & bioscience 2018;8:41
Cell & bioscience 2018;8:41
Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation.
Huang T, Sun Y, Li Y, Wang T, Fu Y, Li C, Li C
Oxidative medicine and cellular longevity 2018;2018:4928703
Oxidative medicine and cellular longevity 2018;2018:4928703
Fasting up-regulates ferroportin 1 expression via a Ghrelin/GHSR/MAPK signaling pathway.
Luo QQ, Zhou YF, Chen MY, Liu L, Ma J, Zhang MW, Zhang FL, Ke Y, Qian ZM
Journal of cellular physiology 2018 Jan;233(1):30-37
Journal of cellular physiology 2018 Jan;233(1):30-37
Aspirin increases ferroportin 1 expression by inhibiting hepcidin via the JAK/STAT3 pathway in interleukin 6-treated PC-12 cells.
Huang SN, Ruan HZ, Chen MY, Zhou G, Qian ZM
Neuroscience letters 2018 Jan 1;662:1-5
Neuroscience letters 2018 Jan 1;662:1-5
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Zhang MW, Zhao P, Yung WH, Sheng Y, Ke Y, Qian ZM
Aging 2018 Dec 16;10(12):3834-3850
Aging 2018 Dec 16;10(12):3834-3850
Different Characteristics of Hepcidin Expression in IL-6+/+ and IL-6-/- Neurons and Astrocytes Treated with Lipopolysaccharides.
Ma J, Zhang FL, Zhou G, Bao YX, Shen Y, Qian ZM
Neurochemical research 2018 Aug;43(8):1624-1630
Neurochemical research 2018 Aug;43(8):1624-1630
Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.
Zhou YF, Zhang C, Yang G, Qian ZM, Zhang MW, Ma J, Zhang FL, Ke Y
Frontiers in physiology 2017;8:332
Frontiers in physiology 2017;8:332
Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis.
Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner HL, Lassmann H
Brain : a journal of neurology 2017 Jul 1;140(7):1900-1913
Brain : a journal of neurology 2017 Jul 1;140(7):1900-1913
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells.
Chen P, Li FM, Zhou YF, Qian C, Li J, Jiang LR, Qian ZM
Pharmacological reports : PR 2017 Feb;69(1):1-5
Pharmacological reports : PR 2017 Feb;69(1):1-5
Digital gene expression profiling analysis of duodenum transcriptomes in SD rats administered ferrous sulfate or ferrous glycine chelate by gavage.
Zhuo Z, Fang S, Hu Q, Huang D, Feng J
Scientific reports 2016 Nov 30;6:37923
Scientific reports 2016 Nov 30;6:37923
Nuclear transcription factor Nrf2 suppresses prostate cancer cells growth and migration through upregulating ferroportin.
Xue D, Zhou C, Shi Y, Lu H, Xu R, He X
Oncotarget 2016 Nov 29;7(48):78804-78812
Oncotarget 2016 Nov 29;7(48):78804-78812
Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure.
Pettiglio MA, Herrera C, Foster ML, Dorman DC, Bartnikas TB
Data in brief 2016 Mar;6:989-97
Data in brief 2016 Mar;6:989-97
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Zhang YT, Li FM, Guo YZ, Jiang LR, Ma J, Ke Y, Qian ZM
European journal of pharmacology 2016 Dec 5;792:48-53
European journal of pharmacology 2016 Dec 5;792:48-53
Effects of aspirin on expression of iron transport and storage proteins in BV-2 microglial cells.
Xu YX, Du F, Jiang LR, Gong J, Zhou YF, Luo QQ, Qian ZM, Ke Y
Neurochemistry international 2015 Dec;91:72-7
Neurochemistry international 2015 Dec;91:72-7
Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma.
Chen RX, Song HY, Dong YY, Hu C, Zheng QD, Xue TC, Liu XH, Zhang Y, Chen J, Ren ZG, Liu YK, Cui JF
PloS one 2014;9(3):e88543
PloS one 2014;9(3):e88543
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO
Nature cell biology 2014 Nov;16(11):1069-79
Nature cell biology 2014 Nov;16(11):1069-79
Iron and neurodegeneration in the multiple sclerosis brain.
Hametner S, Wimmer I, Haider L, Pfeifenbring S, Brück W, Lassmann H
Annals of neurology 2013 Dec;74(6):848-61
Annals of neurology 2013 Dec;74(6):848-61
Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.
Bagnato F, Hametner S, Yao B, van Gelderen P, Merkle H, Cantor FK, Lassmann H, Duyn JH
Brain : a journal of neurology 2011 Dec;134(Pt 12):3602-15
Brain : a journal of neurology 2011 Dec;134(Pt 12):3602-15
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human placenta tissue were subjected to SDS PAGE followed by western blot with 10727-1-AP(FTL antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FTL (IP:10727-1-AP, 3ug; Detection:10727-1-AP 1:1000) with mouse liver tissue lysate 12500ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Ferritin light chain antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Ferritin light chain. This antibody recognizes human,mouse,rat antigen. The Ferritin light chain antibody has been validated for the following applications: ELISA, WB, IP, IHC analysis.
