KCNA7

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel subfamily A member 7

Tissue specificity

Group enriched (skeletal muscle, tongue)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Voltage-gated ion channels

Chromosome

19 (49067418 - 49072941)

Ensembl ID

ENSG00000104848  (ver. 103.38)

Orthologs

Mouse Kcna7: ENSMUSG00000038201

UniProt

Q96RP8

neXtProt

NX_Q96RP8

Human splice variants
Mouse splice variants

Protein structure