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- Antibody Data
- Antigen structure
- References [14]
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- Immunohistochemistry [3]
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- Product number
- NB300-581 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB300-581, RRID:AB_2061431
- Product name
- Mouse Monoclonal SERCA2 ATPase Antibody
- Antibody type
- Monoclonal
- Description
- Unpurified. Detects sarcoplasmic or endoplasmic reticulum calcium (SERCA) 2 ATPase. NB300-581 recognizes the SERCA2a and SERCA2b isoforms identically. However, the antibody does not recognize the skeletal muscle (SERCA1) or housekeeping isoforms (SERCA3).
- Reactivity
- Human, Mouse, Rat, Canine, Guinea Pig, Porcine, Rabbit, Sheep
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 100 uL
- Storage
- Store at -20C. Avoid freeze-thaw cycles.
Submitted references Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.
Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity.
Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics.
Right ventricular pacing with mechanical dyssynchrony causes apoptosis interruptus and calcium mishandling.
Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle.
Phenylephrine hypertrophy, Ca2+-ATPase (SERCA2), and Ca2+ signaling in neonatal rat cardiac myocytes.
Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2.
Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling.
Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum).
Regional alterations in protein expression in the dyssynchronous failing heart.
Sarcolipin overexpression in rat slow twitch muscle inhibits sarcoplasmic reticulum Ca2+ uptake and impairs contractile function.
Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs).
Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.
Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.
Xie D, Geng L, Xiong K, Zhao T, Wang S, Xue J, Wang C, Wang G, Feng Z, Zhou H, Li Y, Li L, Liu Y, Xue Z, Yang J, Ma H, Liang D, Chen YH
Circulation research 2020 Jun 5;126(12):1706-1720
Circulation research 2020 Jun 5;126(12):1706-1720
Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity.
Chung YJ, Luo A, Park KC, Loonat AA, Lakhal-Littleton S, Robbins PA, Swietach P
JCI insight 2019 Apr 4;4(7)
JCI insight 2019 Apr 4;4(7)
Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics.
Schroeder MA, Ali MA, Hulikova A, Supuran CT, Clarke K, Vaughan-Jones RD, Tyler DJ, Swietach P
Proceedings of the National Academy of Sciences of the United States of America 2013 Mar 5;110(10):E958-67
Proceedings of the National Academy of Sciences of the United States of America 2013 Mar 5;110(10):E958-67
Right ventricular pacing with mechanical dyssynchrony causes apoptosis interruptus and calcium mishandling.
Klug D, Boule S, Wissocque L, Montaigne D, Marechal X, Hassoun SM, Neviere R
The Canadian journal of cardiology 2013 Apr;29(4):510-8
The Canadian journal of cardiology 2013 Apr;29(4):510-8
Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle.
García-Pérez C, Hajnóczky G, Csordás G
The Journal of biological chemistry 2008 Nov 21;283(47):32771-80
The Journal of biological chemistry 2008 Nov 21;283(47):32771-80
Phenylephrine hypertrophy, Ca2+-ATPase (SERCA2), and Ca2+ signaling in neonatal rat cardiac myocytes.
Prasad AM, Ma H, Sumbilla C, Lee DI, Klein MG, Inesi G
American journal of physiology. Cell physiology 2007 Jun;292(6):C2269-75
American journal of physiology. Cell physiology 2007 Jun;292(6):C2269-75
Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2.
Anyatonwu GI, Estrada M, Tian X, Somlo S, Ehrlich BE
Proceedings of the National Academy of Sciences of the United States of America 2007 Apr 10;104(15):6454-9
Proceedings of the National Academy of Sciences of the United States of America 2007 Apr 10;104(15):6454-9
Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling.
Khan SA, Lee K, Minhas KM, Gonzalez DR, Raju SV, Tejani AD, Li D, Berkowitz DE, Hare JM
Proceedings of the National Academy of Sciences of the United States of America 2004 Nov 9;101(45):15944-8
Proceedings of the National Academy of Sciences of the United States of America 2004 Nov 9;101(45):15944-8
Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum).
Krizaj D, Liu X, Copenhagen DR
The Journal of comparative neurology 2004 Aug 2;475(4):463-80
The Journal of comparative neurology 2004 Aug 2;475(4):463-80
Regional alterations in protein expression in the dyssynchronous failing heart.
Spragg DD, Leclercq C, Loghmani M, Faris OP, Tunin RS, DiSilvestre D, McVeigh ER, Tomaselli GF, Kass DA
Circulation 2003 Aug 26;108(8):929-32
Circulation 2003 Aug 26;108(8):929-32
Sarcolipin overexpression in rat slow twitch muscle inhibits sarcoplasmic reticulum Ca2+ uptake and impairs contractile function.
Tupling AR, Asahi M, MacLennan DH
The Journal of biological chemistry 2002 Nov 22;277(47):44740-6
The Journal of biological chemistry 2002 Nov 22;277(47):44740-6
Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs).
Asahi M, Kurzydlowski K, Tada M, MacLennan DH
The Journal of biological chemistry 2002 Jul 26;277(30):26725-8
The Journal of biological chemistry 2002 Jul 26;277(30):26725-8
Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.
Movsesian MA, Karimi M, Green K, Jones LR
Circulation 1994 Aug;90(2):653-7
Circulation 1994 Aug;90(2):653-7
Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.
Movsesian MA, Karimi M, Green K, Jones LR
Circulation 1994 Aug;90(2):653-7
Circulation 1994 Aug;90(2):653-7
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: SERCA2 ATPase Antibody (2A7-A1) [NB300-581] - Both normal and cancer biopsies of deparaffinized Human skeletal muscle tissues.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: SERCA2 ATPase Antibody (2A7-A1) [NB300-581] - Both normal and cancer biopsies of deparaffinized Human tonsil tissues.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: SERCA2 ATPase Antibody (2A7-A1) [NB300-581] - Both normal and cancer biopsies of deparaffinized Human liver tissues.
