Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- PAB8487 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB8487, RRID:AB_1676442
- Product name
- MDC1 polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of MDC1.
- Storage
- Store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.
NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage.
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.
MDC1 is required for the intra-S-phase DNA damage checkpoint.
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.
Xu X, Stern DF
The Journal of biological chemistry 2003 Mar 7;278(10):8795-803
The Journal of biological chemistry 2003 Mar 7;278(10):8795-803
NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage.
Peng A, Chen PL
The Journal of biological chemistry 2003 Mar 14;278(11):8873-6
The Journal of biological chemistry 2003 Mar 14;278(11):8873-6
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.
Lou Z, Minter-Dykhouse K, Wu X, Chen J
Nature 2003 Feb 27;421(6926):957-61
Nature 2003 Feb 27;421(6926):957-61
MDC1 is required for the intra-S-phase DNA damage checkpoint.
Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP
Nature 2003 Feb 27;421(6926):952-6
Nature 2003 Feb 27;421(6926):952-6
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.
Lou Z, Chini CC, Minter-Dykhouse K, Chen J
The Journal of biological chemistry 2003 Apr 18;278(16):13599-602
The Journal of biological chemistry 2003 Apr 18;278(16):13599-602
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of extract from 293T (lane 1) and HeLa cells (lane 2) , using MDC1 polyclonal antibody (Cat # PAB8487) .