Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 335001 - Provider product page
- Provider
- BioLegend
- Product name
- PerCP/Cy5.5 anti-human CD185 (CXCR5)
- Antibody type
- Monoclonal
- Antigen
- CD185 (CXCR5)
- Description
- CXCR5 is a chemokine receptor which binds to CXCL13. CXCR5 is expressed in B cells and T folicular helper (TFH) cells (1). CXCR5 is required for migration of B cells to the follicular compartment in the spleen, lymph nodes, Peyer's patches, and tonsils, and normal maturation of primary follicle follicular dendritic cells (2, 3). CXCR5 and CXCL13 contribute in the B cell homing to Peyer's patches (4). In addition, T cell CXCR5 is required for germinal center response of normal magnitude (5).
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Far-Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses.
Kashiwakuma D, Suto A, Hiramatsu Y, Ikeda K, Takatori H, Suzuki K, Kagami S, Hirose K, Watanabe N, Iwamoto I, Nakajima H
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 1;185(5):2730-6
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 1;185(5):2730-6
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with CD19 (HIB19) PE and TG2/CXCR5 PerCP/Cy5.5