BS7261

antibody from Bioworld Technology, Inc
Targeting: DARS1 DARS
Provider product page for BS7261
Western blot
Immunohistochemistry

Antibody data

Product number
BS7261 - Provider product page
Provider
Bioworld Technology, Inc
Product name
DARS polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human DARS.
Description
Aminoacyl-tRNA synthetases consist of a family of enzymes that catalyze the specific aminoacylation of cognate tRNA in the initial step of ribosome-dependent protein biosynthesis. DaRS is part of a multisubunit complex of aminoacyl-tRNA synthetases and is involved in the transfer of Asp-tRNA to EF-1 Ï«1 (elongation factor Ï« 1). The N-terminus of DaRS in vertebrates is a newly evolved structure that contains a putative amphiphilic helix and is dissimilar between different species. The N-terminal extension acts as a switch that, when in its stretched form, reduces the rate of dissociation of Asp-tRNA from DaRS, thereby providing enough time for EF-1 Ï«1 to interact with Asp-tRNA. This suggests that the N-terminus of DaRS plays a critical role in its catalytic function. DaRS contains two phosphorylations sites, forms homodimers and localizes to the cytoplasm.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
DARS1 protein structure - BS7261 shown in red.