MB0162

antibody from Bioworld Technology, Inc
Targeting: RAD9A RAD9
Provider product page for MB0162
Western blot
Immunoprecipitation

Antibody data

Product number
MB0162 - Provider product page
Provider
Bioworld Technology, Inc
Product name
RAD9A monoclonal antibody
Antibody type
Monoclonal
Antigen
Recombinant full length Human RAD9A.
Description
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C(RFC)clamp loader complex.Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair(LP-BER).The 9-1-1 complex stimulates DNA polymerase beta(POLB)activity by increasing its affinity for the 3¡É-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds;endonuclease FEN1 cleavage activity on substrates with double,nick,or gap flaps of distinct sequences and lengths;and DNA ligase I(LIG1)on long-patch base excision repair substrates.The 9-1-1 complex is necessary for the recruitment of C12orf32/RHINO to sites of double-stranded breaks(DSB)occurring during the S phase.RAD9A possesses 3¡É->5¡É double stranded DNA exonuclease activity.Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
Reactivity
Human, Mouse, Rat, Simian
Host
Mouse
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RAD9A protein structure - MB0162 shown in red.