CABT-B9339

antibody from Creative Diagnostics

Targeting: TIAL1 TIAR

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9339

Provider

Creative Diagnostics

Product name

Mouse anti-Human TIAR monoclonal antibody, clone 7/UJBS

Antibody type

Monoclonal

Description

TIAR is an RNA-binding protein related to TIA-1. Both proteins are candidate effectors of apoptotic cell death and consist of three N-terminal RNA-recognition motifs (RRM) and a C-terminal protein-interaction domain (PID). Unlike TIA-1, which is localized in the granules of cytotoxic lymphocytes, TIAR is predominantly found in the nucleus of many different cell types. Two related isoforms (42 kDa and 50 kDa) of TIAR have been identified. It has been demonstrated that TIAR can trigger DNA fragmentation in permeabilized thymocytes, suggesting that it may be an effector of apoptotic cell death. During Fas-mediated apoptosis, TIAR shows a rapid translocation from the nucleus to the cytoplasm. This redistribution of TIAR appears to be a specific event and possibly a general feature of the apoptotic program.

Reactivity

Human, Mouse, Rat, Canine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

7/UJBS

Vial size

50 _g

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.