Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 13194-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13194-1-AP, RRID:AB_2110702
- Product name
- FXR1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FXR1 antibody (Cat. #13194-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle.
RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.
The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.
FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG.
Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.
Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.
Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.
Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.
Denes LT, Kelley CP, Wang ET
Nature communications 2021 Oct 27;12(1):6079
Nature communications 2021 Oct 27;12(1):6079
RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.
George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P
Cell reports 2021 Nov 2;37(5):109934
Cell reports 2021 Nov 2;37(5):109934
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Bai X, Fu R, Duan Z, Liu Y, Zhu C, Fan D
Food & function 2021 Apr 7;12(7):2874-2885
Food & function 2021 Apr 7;12(7):2874-2885
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132
iScience 2020 May 22;23(5):101132
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.
Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, Whitney G, Lyons SM, Anderson P, Jacobs WM, Ivanov P, Brangwynne CP
Cell 2020 Apr 16;181(2):306-324.e28
Cell 2020 Apr 16;181(2):306-324.e28
The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.
Baquero-Perez B, Antanaviciute A, Yonchev ID, Carr IM, Wilson SA, Whitehouse A
eLife 2019 Oct 24;8
eLife 2019 Oct 24;8
FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG.
Cao S, Zheng J, Liu X, Liu Y, Ruan X, Ma J, Liu L, Wang D, Yang C, Cai H, Li Z, Feng Z, Xue Y
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):37
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):37
Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.
Estañ MC, Fernández-Núñez E, Zaki MS, Esteban MI, Donkervoort S, Hawkins C, Caparros-Martin JA, Saade D, Hu Y, Bolduc V, Chao KR, Nevado J, Lamuedra A, Largo R, Herrero-Beaumont G, Regadera J, Hernandez-Chico C, Tizzano EF, Martinez-Glez V, Carvajal JJ, Zong R, Nelson DL, Otaify GA, Temtamy S, Aglan M, Issa M, Bönnemann CG, Lapunzina P, Yoon G, Ruiz-Perez VL
Nature communications 2019 Feb 15;10(1):797
Nature communications 2019 Feb 15;10(1):797
Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.
Wang GX, Smith SJ, Mourrain P
eLife 2016 Oct 22;5
eLife 2016 Oct 22;5
Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.
Lewkowicz P, Cwiklińska H, Mycko MP, Cichalewska M, Domowicz M, Lewkowicz N, Jurewicz A, Selmaj KW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 13;35(19):7521-37
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 13;35(19):7521-37
Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.
Wang GX, Smith SJ, Mourrain P
Neuron 2014 Dec 17;84(6):1273-86
Neuron 2014 Dec 17;84(6):1273-86
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 13194-1-AP(FXR1 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FXR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FXR1. This antibody recognizes human,mouse,rat antigen. The FXR1 antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FXR1 (IP:13194-1-AP, 3ug; Detection:13194-1-AP 1:800) with mouse skeletal muscle tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 13194-1-AP(FXR1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue