Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 13194-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13194-1-AP, RRID:AB_2110702
- Product name
- FXR1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FXR1 antibody (Cat. #13194-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Multiplexed Immunofluorescence and Single-Molecule RNA Fluorescence In Situ Hybridization in Mouse Skeletal Myofibers.
Obeticholic acid protects against lithocholic acid-induced exogenous cell apoptosis during cholestatic liver injury.
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
FXR1 stabilizes SNORD63 to regulate blood-tumor barrier permeability through SNORD63 mediated 2'-O-methylation of POU6F1.
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.
FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.
Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury.
Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle.
RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.
The Tudor SND1 protein is an m(6)A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.
FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG.
Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.
Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.
Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.
Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.
Denes LT, Kelley CP, Wang ET
Methods in molecular biology (Clifton, N.J.) 2024;2784:163-176
Methods in molecular biology (Clifton, N.J.) 2024;2784:163-176
Obeticholic acid protects against lithocholic acid-induced exogenous cell apoptosis during cholestatic liver injury.
Lu Q, Zhu Y, Wang C, Zhang R, Miao Y, Chai Y, Jiang Z, Yu Q
Life sciences 2024 Jan 15;337:122355
Life sciences 2024 Jan 15;337:122355
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Wang X, Fan X, Zhang J, Wang F, Chen J, Wen Y, Wang L, Li T, Li H, Gu H, Zhang Y, Yuan S
Cell reports 2024 Feb 27;43(2):113769
Cell reports 2024 Feb 27;43(2):113769
FXR1 stabilizes SNORD63 to regulate blood-tumor barrier permeability through SNORD63 mediated 2'-O-methylation of POU6F1.
Liang C, Zhai B, Wei D, Niu B, Ma J, Yao Y, Lin Y, Liu Y, Liu X, Wang P
International journal of biological macromolecules 2024 Apr;265(Pt 1):130642
International journal of biological macromolecules 2024 Apr;265(Pt 1):130642
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Fu Y, Li L, Zhang X, Deng Z, Wu Y, Chen W, Liu Y, He S, Wang J, Xie Y, Tu Z, Lyu Y, Wei Y, Wang S, Cui CP, Liu CH, Zhang L
Nature communications 2024 Apr 6;15(1):2974
Nature communications 2024 Apr 6;15(1):2974
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Hsu YH, Pintacuda G, Liu R, Nacu E, Kim A, Tsafou K, Petrossian N, Crotty W, Suh JM, Riseman J, Martin JM, Biagini JC, Mena D, Ching JKT, Malolepsza E, Li T, Singh T, Ge T, Egri SB, Tanenbaum B, Stanclift CR, Apffel AM, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Carr SA, Schenone M, Jaffe J, Fornelos N, Huang H, Eggan KC, Lage K
iScience 2023 May 19;26(5):106701
iScience 2023 May 19;26(5):106701
CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.
Wen C, Li Y, Huang Y, Wang N, He S, Bao M, Zhou H, Wu L
The international journal of biochemistry & cell biology 2023 Jan;154:106344
The international journal of biochemistry & cell biology 2023 Jan;154:106344
FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.
Shimizu H, Hohjoh H
Scientific reports 2023 Feb 2;13(1):1956
Scientific reports 2023 Feb 2;13(1):1956
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
He J, Yang Y, Zhang F, Li Y, Li X, Pu X, He X, Zhang M, Yang X, Yu Q, Qi Y, Li X, Yu J
Frontiers in pharmacology 2022;13:1007274
Frontiers in pharmacology 2022;13:1007274
Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.
Datta C, Truesdell SS, Wu KQ, Bukhari SIA, Ngue H, Buchanan B, Le Tonqueze O, Lee S, Kollu S, Granovetter MA, Boukhali M, Kreuzer J, Batool MS, Balaj L, Haas W, Vasudevan S
Science advances 2022 Oct 28;8(43):eabo1304
Science advances 2022 Oct 28;8(43):eabo1304
Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury.
Hou Z, Ding Q, Li Y, Zhao Z, Yan F, Li Y, Wang X, Xu J, Chen W, Wu G, Ruan X, Zhao L
EBioMedicine 2022 Aug;82:104181
EBioMedicine 2022 Aug;82:104181
Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle.
Denes LT, Kelley CP, Wang ET
Nature communications 2021 Oct 27;12(1):6079
Nature communications 2021 Oct 27;12(1):6079
RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.
George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P
Cell reports 2021 Nov 2;37(5):109934
Cell reports 2021 Nov 2;37(5):109934
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Bai X, Fu R, Duan Z, Liu Y, Zhu C, Fan D
Food & function 2021 Apr 7;12(7):2874-2885
Food & function 2021 Apr 7;12(7):2874-2885
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132
iScience 2020 May 22;23(5):101132
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.
Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, Whitney G, Lyons SM, Anderson P, Jacobs WM, Ivanov P, Brangwynne CP
Cell 2020 Apr 16;181(2):306-324.e28
Cell 2020 Apr 16;181(2):306-324.e28
The Tudor SND1 protein is an m(6)A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.
Baquero-Perez B, Antanaviciute A, Yonchev ID, Carr IM, Wilson SA, Whitehouse A
eLife 2019 Oct 24;8
eLife 2019 Oct 24;8
FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG.
Cao S, Zheng J, Liu X, Liu Y, Ruan X, Ma J, Liu L, Wang D, Yang C, Cai H, Li Z, Feng Z, Xue Y
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):37
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):37
Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.
Estañ MC, Fernández-Núñez E, Zaki MS, Esteban MI, Donkervoort S, Hawkins C, Caparros-Martin JA, Saade D, Hu Y, Bolduc V, Chao KR, Nevado J, Lamuedra A, Largo R, Herrero-Beaumont G, Regadera J, Hernandez-Chico C, Tizzano EF, Martinez-Glez V, Carvajal JJ, Zong R, Nelson DL, Otaify GA, Temtamy S, Aglan M, Issa M, Bönnemann CG, Lapunzina P, Yoon G, Ruiz-Perez VL
Nature communications 2019 Feb 15;10(1):797
Nature communications 2019 Feb 15;10(1):797
Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.
Wang GX, Smith SJ, Mourrain P
eLife 2016 Oct 22;5
eLife 2016 Oct 22;5
Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.
Lewkowicz P, Cwiklińska H, Mycko MP, Cichalewska M, Domowicz M, Lewkowicz N, Jurewicz A, Selmaj KW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 13;35(19):7521-37
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 13;35(19):7521-37
Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.
Wang GX, Smith SJ, Mourrain P
Neuron 2014 Dec 17;84(6):1273-86
Neuron 2014 Dec 17;84(6):1273-86
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 13194-1-AP(FXR1 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FXR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FXR1. This antibody recognizes human,mouse,rat antigen. The FXR1 antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FXR1 (IP:13194-1-AP, 3ug; Detection:13194-1-AP 1:800) with mouse skeletal muscle tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 13194-1-AP(FXR1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue