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- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- ABIN500451 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- PARL antibody was raised against a 15 amino acid peptide from near the amino terminus of human PARL.
- Description
- Peptide affinity chromatography
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- N-Term
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store at 2 - 8°C for up to one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.
The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes.
PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2.
Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN
Nature 2008 Mar 6;452(7183):98-102
Nature 2008 Mar 6;452(7183):98-102
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.
Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B
Cell 2006 Jul 14;126(1):163-75
Cell 2006 Jul 14;126(1):163-75
The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes.
Walder K, Kerr-Bayles L, Civitarese A, Jowett J, Curran J, Elliott K, Trevaskis J, Bishara N, Zimmet P, Mandarino L, Ravussin E, Blangero J, Kissebah A, Collier GR
Diabetologia 2005 Mar;48(3):459-68
Diabetologia 2005 Mar;48(3):459-68
PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2.
Pellegrini L, Passer BJ, Canelles M, Lefterov I, Ganjei JK, Fowlkes BJ, Koonin EV, D'Adamio L
Journal of Alzheimer's disease : JAD 2001 Apr;3(2):181-190
Journal of Alzheimer's disease : JAD 2001 Apr;3(2):181-190
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of PARL in 3T3 cell lysate with AP30647PU-N at (A) 1 and (B) 2 ?g/ml.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunocytochemistry of PARL in 3T3 cells with AP30647PU-N at 2.5 ?g/ml.
