Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 17968-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17968-1-AP, RRID:AB_2165202
- Product name
- uPA/Urokinase antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated uPA/Urokinase antibody (Cat. #17968-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice.
PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.
PLAU1 Facilitated Proliferation, Invasion, and Metastasis via Interaction With MMP1 in Head and Neck Squamous Carcinoma.
PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment.
RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation.
p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi.
Urokinase-type Plasminogen Activator Is a Therapeutic Target for Overcoming Sorafenib Resistance in Hepatoma Cells.
MiR-645 promotes invasiveness, metastasis and tumor growth in colorectal cancer by targeting EFNA5.
Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.
NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium.
MicroRNA-378-3p/5p suppresses the migration and invasiveness of oral squamous carcinoma cells by inhibiting KLK4 expression.
Transcriptome sequencing reveals fibrotic associated-genes involved in bovine mammary fibroblasts with Staphylococcus aureus.
Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways.
Rg3 inhibits gemcitabine-induced lung cancer cell invasiveness through ROS-dependent, NF-κB- and HIF-1α-mediated downregulation of PTX3.
α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression.
Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells.
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells.
Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells.
Identification of potential targets for diallyl disulfide in human gastric cancer MGC-803 cells using proteomics approaches.
Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9-mediated cytokine release from myeloid cells.
Kohara Y, Kitazawa R, Haraguchi R, Imai Y, Kitazawa S
Bone 2022 Jan;154:116200
Bone 2022 Jan;154:116200
PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.
Chen G, Sun J, Xie M, Yu S, Tang Q, Chen L
Frontiers in genetics 2021;12:651882
Frontiers in genetics 2021;12:651882
PLAU1 Facilitated Proliferation, Invasion, and Metastasis via Interaction With MMP1 in Head and Neck Squamous Carcinoma.
Wu K, Mao YY, Han NN, Wu H, Zhang S
Frontiers in oncology 2021;11:574260
Frontiers in oncology 2021;11:574260
PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
Cheng YW, Zhang ZB, Lan BD, Lin JR, Chen XH, Kong LR, Xu L, Ruan CC, Gao PJ
The Journal of experimental medicine 2021 Sep 6;218(9)
The Journal of experimental medicine 2021 Sep 6;218(9)
The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment.
Fu H, Gui Y, Liu S, Wang Y, Bastacky SI, Qiao Y, Zhang R, Bonin C, Hargis G, Yu Y, Kreutzer DL, Biswas PS, Zhou Y, Wang Y, Tian XJ, Liu Y, Zhou D
iScience 2021 Oct 22;24(10):103112
iScience 2021 Oct 22;24(10):103112
RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation.
Geng W, Ren J, Shi H, Qin F, Xu X, Xiao S, Jiao Y, Wang A
Journal of cellular physiology 2021 Mar;236(3):2214-2225
Journal of cellular physiology 2021 Mar;236(3):2214-2225
p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi.
Tan X, Banerjee P, Shi L, Xiao GY, Rodriguez BL, Grzeskowiak CL, Liu X, Yu J, Gibbons DL, Russell WK, Creighton CJ, Kurie JM
Science advances 2021 Jun;7(25)
Science advances 2021 Jun;7(25)
Urokinase-type Plasminogen Activator Is a Therapeutic Target for Overcoming Sorafenib Resistance in Hepatoma Cells.
Osawa M, Matsuda Y, Kinoshita Y, Wakai T
Anticancer research 2021 Feb;41(2):645-660
Anticancer research 2021 Feb;41(2):645-660
MiR-645 promotes invasiveness, metastasis and tumor growth in colorectal cancer by targeting EFNA5.
Li S, Hou X, Wu C, Han L, Li Q, Wang J, Luo S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109889
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109889
Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.
Li G, Lin J, Peng Y, Qin K, Wen L, Zhao T, Feng Q
Phytotherapy research : PTR 2020 Jun;34(6):1421-1435
Phytotherapy research : PTR 2020 Jun;34(6):1421-1435
NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium.
Ma P, Li G, Jiang X, Shen X, Li H, Yang L, Liu W
Aging 2020 Dec 19;13(3):3661-3679
Aging 2020 Dec 19;13(3):3661-3679
MicroRNA-378-3p/5p suppresses the migration and invasiveness of oral squamous carcinoma cells by inhibiting KLK4 expression.
Cui Z, Sun S, Liu Q, Zhou X, Gao S, Peng P, Li Q
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):154-163
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):154-163
Transcriptome sequencing reveals fibrotic associated-genes involved in bovine mammary fibroblasts with Staphylococcus aureus.
Miao Z, Ding Y, Zhao N, Chen X, Cheng H, Wang J, Liu Y, Wang F
The international journal of biochemistry & cell biology 2020 Apr;121:105696
The international journal of biochemistry & cell biology 2020 Apr;121:105696
Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways.
Wu YJ, Lin SH, Din ZH, Su JH, Liu CI
Marine drugs 2019 Nov 27;17(12)
Marine drugs 2019 Nov 27;17(12)
Rg3 inhibits gemcitabine-induced lung cancer cell invasiveness through ROS-dependent, NF-κB- and HIF-1α-mediated downregulation of PTX3.
Ahmmed B, Kampo S, Khan M, Faqeer A, Kumar SP, Yulin L, Liu JW, Yan Q
Journal of cellular physiology 2019 Jul;234(7):10680-10697
Journal of cellular physiology 2019 Jul;234(7):10680-10697
α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression.
Chen H, Xu Z, Li X, Yang Y, Li B, Li Y, Xia K, Wang J, Li S, Wang M, Wu H
Oncogenesis 2018 Mar 13;7(3):28
Oncogenesis 2018 Mar 13;7(3):28
Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells.
Tian YS, Chen KC, Zulkefli ND, Maner RS, Hsieh CL
Molecules (Basel, Switzerland) 2018 Dec 14;23(12)
Molecules (Basel, Switzerland) 2018 Dec 14;23(12)
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Sun D, Liu Y, Wang H, Deng F, Zhang Y, Zhao S, Ma X, Wu H, Sun G
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells.
Wang J, Wu Y, Guo J, Fei X, Yu L, Ma S
Oncotarget 2017 Oct 10;8(47):81880-81891
Oncotarget 2017 Oct 10;8(47):81880-81891
Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells.
Liu Y, Wang S, Sun D, Liu Y, Liu Y, Wang Y, Liu C, Wu H, Lv Y, Ren Y, Guo X, Sun G, Ma X
Scientific reports 2016 Jul 19;6:29858
Scientific reports 2016 Jul 19;6:29858
Identification of potential targets for diallyl disulfide in human gastric cancer MGC-803 cells using proteomics approaches.
Su B, Su J, He H, Wu Y, Xia H, Zeng X, Dai W, Ai X, Ling H, Jiang H, Su Q
Oncology reports 2015 May;33(5):2484-94
Oncology reports 2015 May;33(5):2484-94
Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9-mediated cytokine release from myeloid cells.
Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonsert S, Takeda K, Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, Hattori K
Gastroenterology 2015 Mar;148(3):565-578.e4
Gastroenterology 2015 Mar;148(3):565-578.e4
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 17968-1-AP(uPA antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The uPA antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human uPA. This antibody recognizes human,mouse,rat antigen. The uPA antibody has been validated for the following applications: ELISA, WB, IHC analysis.