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antibody from Invitrogen Antibodies
Targeting: SIGLEC7
CD328, p75/AIRM1, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Flow cytometry [1]
- Other assay [1]
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- Product number
- 14-5759-37 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD328 (Siglec7) Monoclonal Antibody (eBioQA79 (QA79)), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The eBioQA79 monoclonal antibody reacts with adhesion inhibitory receptor molecule 1 (AIRM1), also known as sialic acid binding immunoglobulin-like lectin 7 (Siglec-7), p75 and CDw328. AIRM1 is a cell surface receptor that belongs to the sialoadhesin family and displays homology with the myeloid cell antigen CD33. p75/AIRM1 expression is confined to NK cells in lymphoid cells. eBioQA79 crosslinking inhibits NK function. p75/AIRM1 is expressed at various stages of myeloid differentiation. Presence of this protein is a useful way to monitor cellular proliferation and determine proliferative states of cells, especially in diseases such as chronic myeloid leukemia.
- Antibody clone number
- eBioQA79 (QA79)
- Concentration
- 0.5 mg/mL
Submitted references Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.
On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7.
Kawasaki N, Rillahan CD, Cheng TY, Van Rhijn I, Macauley MS, Moody DB, Paulson JC
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 15;193(4):1560-6
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 15;193(4):1560-6
On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7.
Rillahan CD, Schwartz E, Rademacher C, McBride R, Rangarajan J, Fokin VV, Paulson JC
ACS chemical biology 2013 Jul 19;8(7):1417-22
ACS chemical biology 2013 Jul 19;8(7):1417-22
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with 0.25 µg of Mouse IgG1 kappa Isotype Control Purified (Product # 14-4714-82) (open histogram) or 0.25 µg of Anti-Human CD328 (Siglec7) Purified (filled histogram) followed by F (ab')2 Anti-Mouse IgG PE (Product # 12-4012). Cells in the lymphocyte gate were used for analysis.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
