- HPA000694 - Atlas Antibodies DICER1 antibody

Submitted references Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.

Mito JK, Min HD, Ma Y, Carter JE, Brigman BE, Dodd L, Dankort D, McMahon M, Kirsch DG
The Journal of pathology 2013 Jan;229(1):132-40

Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion.

Jafarnejad SM, Ardekani GS, Ghaffari M, Martinka M, Li G
Oncogene 2013 Apr 25;32(17):2131-9

Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1.

Greenlee AR, Shiao MS, Snyder E, Buaas FW, Gu T, Stearns TM, Sharma M, Murchison EP, Puente GC, Braun RE
PloS one 2012;7(10):e46359

miRNA profiling along tumour progression in ovarian carcinoma

Vaksman O, Stavnes H, Kaern J, Trope C, Davidson B, Reich R
Journal of Cellular and Molecular Medicine 2011 July;15(7):1593-1602

Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition

Montenegro D, Romero R, Kim S, Tarca A, Draghici S, Kusanovic J, Kim J, Lee D, Erez O, Gotsch F, Hassan S, Kim C
The Journal of Pathology 2009 January;217(1):113-121

DICER1 Mutations in Familial Pleuropulmonary Blastoma

Hill D, Ivanovich J, Priest J, Gurnett C, Dehner L, Desruisseau D, Jarzembowski J, Wikenheiser-Brokamp K, Suarez B, Whelan A, Williams G, Bracamontes D, Messinger Y, Goodfellow P
Science 2009 August;325(5943):965-965

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Enhanced validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human endometrium and pancreas tissues using HPA000694 antibody. Corresponding DICER1 RNA-seq data are presented for the same tissues.
Sample type: HUMAN
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in distal tubules and in cells in glomeruli.

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human endometrium shows moderate cytoplasmic positivity in glandular cells.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human cerebellum shows moderate positivity in neuropil.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human pancreas shows weak cytoplasmic positivity in islets of Langerhans, while exocrine cells are mainly negative.
Sample type: HUMAN

HPA000694

Antibody data