347604

antibody from BioLegend

Targeting: SIGLEC10 MGC126774, PRO940, SIGLEC-10, SLG2

Antibody data

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Validation data

Product number: 347604 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#347604, RRID:AB_2189155
Product name: PE anti-human Siglec-10
Antibody type: Monoclonal
Antigen: Recombinant Siglec-10 fused to human IgG Fc
Description: Siglec-10 is a lectin that specifically binds α-2,3- or α-2,6-linked sialic acid. It is a member of the Ig-superfamily and is expressed in monocytes, eosinophils, B cells, and a subset of NK cells. Siglec-10 is a single pass transmembrane protein. The extracellular domain contains one V-set Ig-like domain and three C2-set domains; the cytoplasmic domain contains one immunoreceptor tyrosine-based inhibitor motif (ITIM) which, after tyrosine-phosphorylation, recruits SH2-family phosphatases such as SHP-1 and PTPN6, resulting in the blocking of the signal transduction. CD24 and the vascular adhesion protein-1 (VAP-1) have been described as ligands of Siglec-10.
Reactivity: Human
Host: Mouse
Conjugate: Yellow dye
Isotype: IgG
Vial size: 100 tests
Storage: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

SIGLEC10 protein structure - 347604 shown in red.