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- Product number
- NBP1-89081 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-89081, RRID:AB_11024070
- Product name
- Rabbit Polyclonal ANKS6 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human, zebrafish ANKS6 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse, Rat, Zebrafish
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes.
Mutations in ANKS6 cause a nephronophthisis-like phenotype with ESRD.
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.
Bakey Z, Bihoreau MT, Piedagnel R, Delestré L, Arnould C, de Villiers Ad, Devuyst O, Hoffmann S, Ronco P, Gauguier D, Lelongt B
Kidney international 2015 Aug;88(2):299-310
Kidney international 2015 Aug;88(2):299-310
Mutations in ANKS6 cause a nephronophthisis-like phenotype with ESRD.
Taskiran EZ, Korkmaz E, Gucer S, Kosukcu C, Kaymaz F, Koyunlar C, Bryda EC, Chaki M, Lu D, Vadnagara K, Candan C, Topaloglu R, Schaefer F, Attanasio M, Bergmann C, Ozaltin F
Journal of the American Society of Nephrology : JASN 2014 Aug;25(8):1653-61
Journal of the American Society of Nephrology : JASN 2014 Aug;25(8):1653-61
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.
Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp SS
Nature genetics 2013 Aug;45(8):951-6
Nature genetics 2013 Aug;45(8):951-6
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ANKS6 Antibody [NBP1-89081] - Analysis in human cerebellum (right) tissue.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ANKS6 Antibody [NBP1-89081] - Staining of human cerebral cortex shows strong cytoplasmic positivity in granular pattern in neuronal cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ANKS6 Antibody [NBP1-89081] - Staining of human testis shows moderate to strong granular cytoplasmic positivity in cells in seminiferous ducts and Leydig cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ANKS6 Antibody [NBP1-89081] - Staining of human cerebral cortex shows moderate to strong granular cytoplasmic positivity in neurons.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ANKS6 Antibody [NBP1-89081] - Staining of human kidney shows moderate granular cytoplasmic positivity in cells in tubules.
