ABIN153174

antibody from antibodies-online

Targeting: PRDM1 BLIMP1, PRDI-BF1

Provider product page for ABIN153174

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Chromatin Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [44]
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Validations
Western blot [1]
Immunocytochemistry [1]
Flow cytometry [5]

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Product number: ABIN153174 - Provider product page
Provider: antibodies-online
Product name: anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibody
Antibody type: Monoclonal
Description: Protein G purified
Reactivity: Human, Mouse, Porcine
Host: Mouse
Epitope: AA 199-409
Isotype: IgG
Antibody clone number: 3H2-E8
Vial size: 0.1 mL
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Handling: Avoid freeze-thaw cycles

PRDM1 protein structure - ABIN153174 shown in red.

Submitted references Epstein-Barr virus (EBV) provides survival factors to EBV⁺ diffuse large B-cell lymphoma (DLBCL) lines and modulates cytokine induced specific chemotaxis in EBV⁺ DLBCL.

Wu L, Ehlin-Henriksson B, Zhou X, Zhu H, Ernberg I, Kis LL, Klein G
Immunology 2017 Dec;152(4):562-573

Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia.

McCarthy C, Kenny LC
Scientific reports 2016 Sep 8;6:32683

Rho kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension.

Gosal K, Dunlop K, Dhaliwal R, Ivanovska J, Kantores C, Desjardins JF, Connelly KA, McNamara PJ, Jain A, Jankov RP
American journal of respiratory cell and molecular biology 2015 Jun;52(6):717-27

Mitochondrial function provides instructive signals for activation-induced B-cell fates.

Jang KJ, Mano H, Aoki K, Hayashi T, Muto A, Nambu Y, Takahashi K, Itoh K, Taketani S, Nutt SL, Igarashi K, Shimizu A, Sugai M
Nature communications 2015 Apr 10;6:6750

The MEC1 and MEC2 lines represent two CLL subclones in different stages of progression towards prolymphocytic leukemia.

Rasul E, Salamon D, Nagy N, Leveau B, Banati F, Szenthe K, Koroknai A, Minarovits J, Klein G, Klein E
PloS one 2014;9(8):e106008

C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.

Joo H, Li D, Dullaers M, Kim TW, Duluc D, Upchurch K, Xue Y, Zurawski S, Le Grand R, Liu YJ, Kuroda M, Zurawski G, Oh S
Immunity 2014 Oct 16;41(4):592-604

DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.

Horn M, Geisen C, Cermak L, Becker B, Nakamura S, Klein C, Pagano M, Antebi A
Developmental cell 2014 Mar 31;28(6):697-710

p53 Induces skin aging by depleting Blimp1+ sebaceous gland cells.

Kim J, Nakasaki M, Todorova D, Lake B, Yuan CY, Jamora C, Xu Y
Cell death & disease 2014 Mar 27;5:e1141

The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.

Severa M, Islam SA, Waggoner SN, Jiang Z, Kim ND, Ryan G, Kurt-Jones E, Charo I, Caffrey DR, Boyartchuk VL, Luster AD, Fitzgerald KA
Journal of immunology (Baltimore, Md. : 1950) 2014 Mar 1;192(5):2291-304

Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice.

Kim EH, Gasper DJ, Lee SH, Plisch EH, Svaren J, Suresh M
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 1;192(3):985-95

The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?

Ramon S, Baker SF, Sahler JM, Kim N, Feldsott EA, Serhan CN, Martínez-Sobrido L, Topham DJ, Phipps RP
Journal of immunology (Baltimore, Md. : 1950) 2014 Dec 15;193(12):6031-40

T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells.

Lin MH, Yeh LT, Chen SJ, Chiou HY, Chu CC, Yen LB, Lin KI, Chang DM, Sytwu HK
Clinical immunology (Orlando, Fla.) 2014 Apr;151(2):101-13

IFN-α regulates Blimp-1 expression via miR-23a and miR-125b in both monocytes-derived DC and pDC.

Parlato S, Bruni R, Fragapane P, Salerno D, Marcantonio C, Borghi P, Tataseo P, Ciccaglione AR, Presutti C, Romagnoli G, Bozzoni I, Belardelli F, Gabriele L
PloS one 2013;8(8):e72833

Upregulated hPuf-A promotes breast cancer tumorigenesis.

Fan CC, Lee LY, Yu MY, Tzen CY, Chou C, Chang MS
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Oct;34(5):2557-64

The product of Kaposi's sarcoma-associated herpesvirus immediate early gene K4.2 regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1.

Wong LY, Brulois K, Toth Z, Inn KS, Lee SH, O'Brien K, Lee H, Gao SJ, Cesarman E, Ensser A, Jung JU
Journal of virology 2013 Nov;87(22):12069-79

B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells.

Lin MH, Chou FC, Yeh LT, Fu SH, Chiou HY, Lin KI, Chang DM, Sytwu HK
Diabetologia 2013 Jan;56(1):136-46

Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics.

Takata K, Sato Y, Nakamura N, Tokunaka M, Miki Y, Yukie Kikuti Y, Igarashi K, Ito E, Harigae H, Kato S, Hayashi E, Oka T, Hoshii Y, Tari A, Okada H, Al-Kader LA, Maeda Y, Tanimoto M, Kinoshita T, Yoshino T
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013 Jan;26(1):22-31

Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.

Morgan MA, Mould AW, Li L, Robertson EJ, Bikoff EK
Molecular and cellular biology 2012 Sep;32(17):3403-13

Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells.

Lee SR, Rutan JA, Monteith AJ, Jones SZ, Kang SA, Krum KN, Kilmon MA, Roques JR, Wagner NJ, Clarke SH, Vilen BJ
Journal of immunology (Baltimore, Md. : 1950) 2012 Oct 15;189(8):3859-68

Bim regulates B-cell receptor-mediated apoptosis in the presence of CD40 signaling in CD40-pre-activated splenic B cells differentiating into plasma cells.

Gao Y, Kazama H, Yonehara S
International immunology 2012 May;24(5):283-92

IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.

Altin JA, Goodnow CC, Cook MC
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 1;188(11):5478-88

Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells.

Ramon S, Gao F, Serhan CN, Phipps RP
Journal of immunology (Baltimore, Md. : 1950) 2012 Jul 15;189(2):1036-42

IL-2 requirement for human plasma cell generation: coupling differentiation and proliferation by enhancing MAPK-ERK signaling.

Le Gallou S, Caron G, Delaloy C, Rossille D, Tarte K, Fest T
Journal of immunology (Baltimore, Md. : 1950) 2012 Jul 1;189(1):161-73

Soluble factors produced by activated CD4+ T cells modulate EBV latency.

Nagy N, Adori M, Rasul A, Heuts F, Salamon D, Ujvári D, Madapura HS, Leveau B, Klein G, Klein E
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 31;109(5):1512-7

Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo.

Maseda D, Smith SH, DiLillo DJ, Bryant JM, Candando KM, Weaver CT, Tedder TF
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 1;188(3):1036-48

Identifying regulatory B cells (B10 cells) that produce IL-10 in mice.

Matsushita T, Tedder TF
Methods in molecular biology (Clifton, N.J.) 2011;677:99-111

NANOS3 function in human germ cell development.

Julaton VT, Reijo Pera RA
Human molecular genetics 2011 Jun 1;20(11):2238-50

SUMOylation of Blimp-1 promotes its proteasomal degradation.

Shimshon L, Michaeli A, Hadar R, Nutt SL, David Y, Navon A, Waisman A, Tirosh B
FEBS letters 2011 Aug 4;585(15):2405-9

Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development.

Brzezinski JA 4th, Lamba DA, Reh TA
Development (Cambridge, England) 2010 Feb;137(4):619-29

Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.

Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, Takahashi S, Calame K, Takayanagi H
Proceedings of the National Academy of Sciences of the United States of America 2010 Feb 16;107(7):3117-22

RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1.

Wang X, Belguise K, O'Neill CF, Sánchez-Morgan N, Romagnoli M, Eddy SF, Mineva ND, Yu Z, Min C, Trinkaus-Randall V, Chalbos D, Sonenshein GE
Molecular and cellular biology 2009 Jul;29(14):3832-44

Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation.

Garcia-Bates TM, Baglole CJ, Bernard MP, Murant TI, Simpson-Haidaris PJ, Phipps RP
Journal of immunology (Baltimore, Md. : 1950) 2009 Dec 1;183(11):6903-12

Recurrent inactivation of the PRDM1 gene in primary central nervous system lymphoma.

Courts C, Montesinos-Rongen M, Brunn A, Bug S, Siemer D, Hans V, Blümcke I, Klapper W, Schaller C, Wiestler OD, Küppers R, Siebert R, Deckert M
Journal of neuropathology and experimental neurology 2008 Jul;67(7):720-7

Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1.

John SA, Clements JL, Russell LM, Garrett-Sinha LA
The Journal of biological chemistry 2008 Jan 11;283(2):951-62

Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma.

Liu YY, Leboeuf C, Shi JY, Li JM, Wang L, Shen Y, Garcia JF, Shen ZX, Chen Z, Janin A, Chen SJ, Zhao WL
Blood 2007 Jul 1;110(1):339-44

Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production.

Gong D, Malek TR
Journal of immunology (Baltimore, Md. : 1950) 2007 Jan 1;178(1):242-52

Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice.

Robertson EJ, Charatsi I, Joyner CJ, Koonce CH, Morgan M, Islam A, Paterson C, Lejsek E, Arnold SJ, Kallies A, Nutt SL, Bikoff EK
Development (Cambridge, England) 2007 Dec;134(24):4335-45

Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.

Severa M, Coccia EM, Fitzgerald KA
The Journal of biological chemistry 2006 Sep 8;281(36):26188-95

PRDM1/Blimp-1 is expressed in human B-lymphocytes committed to the plasma cell lineage.

Cattoretti G, Angelin-Duclos C, Shaknovich R, Zhou H, Wang D, Alobeid B
The Journal of pathology 2005 May;206(1):76-86

Blimp1 is a critical determinant of the germ cell lineage in mice.

Ohinata Y, Payer B, O'Carroll D, Ancelin K, Ono Y, Sano M, Barton SC, Obukhanych T, Nussenzweig M, Tarakhovsky A, Saitou M, Surani MA
Nature 2005 Jul 14;436(7048):207-13

The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development.

Chang DH, Cattoretti G, Calame KL
Mechanisms of development 2002 Sep;117(1-2):305-9

Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells.

Lin KI, Angelin-Duclos C, Kuo TC, Calame K
Molecular and cellular biology 2002 Jul;22(13):4771-80

Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo.

Angelin-Duclos C, Cattoretti G, Lin KI, Calame K
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 15;165(10):5462-71

Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation.

Lin Y, Wong K, Calame K
Science (New York, N.Y.) 1997 Apr 25;276(5312):596-9

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