Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 648202 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#648202, RRID:AB_2300132
- Product name
- Purified anti-Blimp-1
- Antibody type
- Monoclonal
- Antigen
- Recombinant GST-blimp-1 protein
- Description
- Blimp-1 is a 98 Kd protein containing five Kuppel-type zinc finger domains that confer sequence specific DNA binding. It has been postulated to be a master regulator of terminal B cell differentiation. In the BCL-1 lymphoma model of differentiation from mature B cells to plasma cells, ectopic expression of Blimp-1 is sufficient to cause terminal differentiation manifested by loss of surface immunoglobulin, IgM secretion, expression of syndecan-1 and cessation of cell division. Recently, it is reported that Blimp-1 is also involved in T cell differentiation and T cell homeostasis and suppression of IL-2 production.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C.
Submitted references Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets.
Travert M, Huang Y, de Leval L, Martin-Garcia N, Delfau-Larue MH, Berger F, Bosq J, Brière J, Soulier J, Macintyre E, Marafioti T, de Reyniès A, Gaulard P
Blood 2012 Jun 14;119(24):5795-806
Blood 2012 Jun 14;119(24):5795-806
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- A20 (lane 1) and PBMC (lane 2)cell extracts were resolved by electrophoresis, transferred to nitrocellulose and probed with anti- BLIMP - 1 antibody, ROS195G. PRoteins were visualized using a HRP goat anti-mouse antibody and a chemiluminescence detection system
- Conjugate
- Unconjugated