Explore
Validate
LearnDM1216
antibody from Acris Antibodies GmbH
Targeting: FPR2
ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH2, FPRL1, HM63, LXA4R
ELISA
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Immunocytochemistry [1]
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- DM1216 - Provider product page
- Provider
- Acris Antibodies GmbH
- Proper citation
- Acris Antibodies GmbH Cat#DM1216, RRID:AB_1001396
- Product name
- anti FPR2 / FPRL1
- Antibody type
- Monoclonal
- Antigen
- GM1D6 was generated by genetic immunisation of BALB/c mice with a proprietary GPCR-immunisation vector containing the FPRL1 cDNA.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- GM-1D6
- Vial size
- 0.1 mg
- Concentration
- 2.0 mg/ml
Submitted references Annexin A1 N-terminal derived peptide Ac2-26 stimulates fibroblast migration in high glucose conditions.
Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils.
Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity.
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.
Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets.
Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.
Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.
ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis.
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.
Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1.
Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells.
Bizzarro V, Fontanella B, Carratù A, Belvedere R, Marfella R, Parente L, Petrella A
PloS one 2012;7(9):e45639
PloS one 2012;7(9):e45639
Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils.
Dalli J, Montero-Melendez T, McArthur S, Perretti M
Frontiers in pharmacology 2012;3:28
Frontiers in pharmacology 2012;3:28
Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity.
Simiele F, Recchiuti A, Mattoscio D, De Luca A, Cianci E, Franchi S, Gatta V, Parolari A, Werba JP, Camera M, Favaloro B, Romano M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Mar;26(3):1323-33
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Mar;26(3):1323-33
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
Bena S, Brancaleone V, Wang JM, Perretti M, Flower RJ
The Journal of biological chemistry 2012 Jul 13;287(29):24690-7
The Journal of biological chemistry 2012 Jul 13;287(29):24690-7
Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.
Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M
Arteriosclerosis, thrombosis, and vascular biology 2012 Aug;32(8):1970-8
Arteriosclerosis, thrombosis, and vascular biology 2012 Aug;32(8):1970-8
Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets.
Spurr L, Nadkarni S, Pederzoli-Ribeil M, Goulding NJ, Perretti M, D'Acquisto F
International immunopharmacology 2011 Jan;11(1):55-66
International immunopharmacology 2011 Jan;11(1):55-66
Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.
Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G, Perretti M
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4905-14
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4905-14
Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.
De Santo C, Arscott R, Booth S, Karydis I, Jones M, Asher R, Salio M, Middleton M, Cerundolo V
Nature immunology 2010 Nov;11(11):1039-46
Nature immunology 2010 Nov;11(11):1039-46
ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis.
Martins V, Valença SS, Farias-Filho FA, Molinaro R, Simões RL, Ferreira TP, e Silva PM, Hogaboam CM, Kunkel SL, Fierro IM, Canetti C, Benjamim CF
Journal of immunology (Baltimore, Md. : 1950) 2009 May 1;182(9):5374-81
Journal of immunology (Baltimore, Md. : 1950) 2009 May 1;182(9):5374-81
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.
Planagumà A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE, Levy BD
American journal of respiratory and critical care medicine 2008 Sep 15;178(6):574-82
American journal of respiratory and critical care medicine 2008 Sep 15;178(6):574-82
Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1.
Björkman L, Karlsson J, Karlsson A, Rabiet MJ, Boulay F, Fu H, Bylund J, Dahlgren C
Journal of leukocyte biology 2008 Feb;83(2):245-53
Journal of leukocyte biology 2008 Feb;83(2):245-53
Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells.
Viswanathan A, Painter RG, Lanson NA Jr, Wang G
Stem cells (Dayton, Ohio) 2007 May;25(5):1263-9
Stem cells (Dayton, Ohio) 2007 May;25(5):1263-9
No comments: Submit comment
Supportive validation
- Submitted by
- Acris Antibodies GmbH (provider)
- Main image
- Experimental details
- Figure 2. Spectral Confocal Microscopy of CHO cells using GM1D6 Cat.-No. DM1216. CHO cells were transiently transfected with an expression vector encoding FPRL1. Binding of GM-1D6 was visualized with a FITC-conjugated secondary antibody (green). Actin filaments are labeled with Alexa Fluor-555 Phalloidin (red). Cell nuclei are stained with DAPI (blue).
Supportive validation
- Submitted by
- Acris Antibodies GmbH (provider)
- Main image
- Experimental details
- Figure 1. FACS analysis of BOSC23 cells using GM1D6 Cat.-No. DM1216. BOSC23 cells were transiently transfected with an expression vector encodingeither FPRL1 (red curve) or an irrelevant protein (control transfectant: black curve). Binding of GM1D6 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with FPRL1 transfected cells.
