DPP4

The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]

Description

Dipeptidyl peptidase 4

Tissue specificity

Tissue enhanced (intestine, parathyroid gland, placenta, prostate)

Predicted location

Intracellular, Secreted to blood

Protein family

CD markers
Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (161992245 - 162074394)

Ensembl ID

ENSG00000197635  (ver. 103.38)

Orthologs

Mouse Dpp4: ENSMUSG00000035000

UniProt

P27487

neXtProt

NX_P27487

Human splice variants
Mouse splice variants

Protein structure