PRDM10

The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Description

PR/SET domain 10

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli fibrillar center, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

11 (129899706 - 130002835)

Ensembl ID

ENSG00000170325  (ver. 103.38)

Orthologs

Mouse Prdm10: ENSMUSG00000042496

UniProt

Q9NQV6

neXtProt

NX_Q9NQV6

Human splice variants
Mouse splice variants

Protein structure