CRLF3

This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]

Description

Cytokine receptor like factor 3

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (30769388 - 30824692)

Ensembl ID

ENSG00000176390  (ver. 103.38)

Orthologs

Mouse Crlf3: ENSMUSG00000017561

UniProt

Q8IUI8

neXtProt

NX_Q8IUI8

Human splice variants
Mouse splice variants

Protein structure