BS7753

antibody from Bioworld Technology, Inc
Targeting: IL1RAP C3orf13, IL-1RAcP, IL1R3
Provider product page for BS7753
Western blot
Immunohistochemistry

Antibody data

Product number
BS7753 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL1RAP polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human IL1RAP.
Description
?Interleukin-1 (IL-1) is a key pro-inflammatory cytokine that has diverse actions in the brain as a regulator of host defense responses and a mediator of inflammation. Two major agonists, IL-1Ï« and IL-1ÉÇ, bind to a single known functional type-1 IL-1 receptor (IL-1RI), which associates with the accessory protein (IL-1RAcP), resulting in signal transduction. IL-1F6, IL-1F8, and IL-1F9 signal through IL-1RAcP to activate NF?B. The membrane bound form of IL-1RAcP (mIL-1RAcP) facilitates signal transduction. Two alternatively spliced isoforms, soluble IL-1RAcP (sIL-1RAcP) and sIL-1RAcP-ÉÇ, which lack transmembrane and intracellular domains, can inhibit IL-1 signaling. Although both mIL-1RAcP and sIL-1RAcP mRNAs are widely expressed in human tissue, their relative proportions differ significantly in a tissue-specific manner.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL1RAP protein structure - BS7753 shown in red.