NB100-64340

antibody from Novus Biologicals
Targeting: C8A
Provider product page for NB100-64340
Western blot
ELISA
Immunohistochemistry
Flow cytometry

Antibody data

Product number
NB100-64340 - Provider product page
Provider
Novus Biologicals
Proper citation
Novus Cat#NB100-64340, RRID:AB_960759
Product name
Mouse Monoclonal Complement C8A/B/G Antibody
Antibody type
Monoclonal
Description
Protein A purified. This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyzes the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
Reactivity
Human
Host
Mouse
Isotype
IgG
Vial size
0.05 mg
Concentration
1.0 mg/ml
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
C8A protein structure - NB100-64340 shown in red.