13989-1-AP

antibody from Proteintech Group

Targeting: ACSL1 ACS1, FACL1, FACL2, LACS, LACS1, LACS2

Provider product page for 13989-1-AP

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Antibody data

Antibody Data
Antigen structure
References [44]
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Validations
Western blot [1]

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Product number: 13989-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13989-1-AP, RRID:AB_2257870
Product name: ACSL1 antibody
Antibody type: Polyclonal
Description: KD/KO validated ACSL1 antibody (Cat. #13989-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ACSL1 protein structure - 13989-1-AP shown in red.

Submitted references APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.

Zhao H, Cheng X, Yan L, Mi F, Wang W, Hu Y, Liu X, Fan Y, Min Q, Wang Y, Zhang W, Wu Q, Zhan Q
Cell communication and signaling : CCS 2024 May 23;22(1):283

Testosterone regulates thymic remodeling by altering metabolic reprogramming in male rats.

Li D, Yao H, Ren Y, Shang J, Han X, Cao X, Song T, Zeng X
General and comparative endocrinology 2024 Mar 1;348:114448

7-Dehydrocholesterol dictates ferroptosis sensitivity.

Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P
Nature 2024 Feb;626(7998):411-418

Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1.

Wright T, Turnis ME, Grace CR, Li X, Brakefield LA, Wang YD, Xu H, Kaminska E, Climer LK, Mukiza TO, Chang CL, Moldoveanu T, Opferman JT
Molecular cell 2024 Apr 4;84(7):1338-1353.e8

Dihydroartemisinin Potentiates VEGFR-TKIs Antitumorigenic Effect on Osteosarcoma by Regulating Loxl2/VEGFA Expression and Lipid Metabolism Pathway.

Ding X, Zhang Y, Liang J, Li Q, Hu H, Zhou Y, Zhang B
Journal of Cancer 2023;14(5):809-820

Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice.

Gao J, Wang A, Bu X, Jia W
Frontiers in immunology 2023;14:1169869

HBx induced upregulation of FATP2 promotes the development of hepatic lipid accumulation.

Lu Y, Yang X, Kuang Q, Wu Y, Tan X, Lan J, Qiang Z, Feng T
Experimental cell research 2023 Sep 1;430(1):113721

Paternal cadmium exposure induces glucolipid metabolic reprogramming in offspring mice via PPAR signaling pathway.

Zeng L, Zhou J, Zhang Y, Wang X, Li Y, Song J, Shao J, Su P
Chemosphere 2023 Oct;339:139592

Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.

Ma B, Ju A, Zhang S, An Q, Xu S, Liu J, Yu L, Fu Y, Luo Y
Signal transduction and targeted therapy 2023 Jun 16;8(1):229

Glycyrrhizic acid glycosides reduces extensive tripterygium glycosides-induced lipid deposition in hepatocytes.

Yang Y, Fu X, Xia B, Zhou L, Zhang H, Li C, Ye X, Liu T
Heliyon 2023 Jul;9(7):e17891

A HIF-1α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells.

Matsufuji S, Kitajima Y, Higure K, Kimura N, Maeda S, Yamada K, Ito K, Tanaka T, Kai K, Noshiro H
Cancer & metabolism 2023 Dec 8;11(1):25

lnc-HC ameliorates steatosis by promoting miR-130b-3p biogenesis and the assembly of an RNA-induced silencing complex.

Lan X, Ren J, Du X, Zhang L, Wang S, Yang X, Lu S
Molecular and cellular endocrinology 2023 Dec 1;578:112061

The multi-omics analyses of acsl1 reveal its translational significance as a tumor microenvironmental and prognostic biomarker in clear cell renal cell carcinoma.

Yang Y, Liang J, Zhao J, Wang X, Feng D, Xu H, Shen Y, Zhang Y, Dai J, Wang Z, Wei Q, Liu Z
Diagnostic pathology 2023 Aug 22;18(1):96

Therapeutic role of Artemether in the prevention of hepatic steatosis through miR-34a-5p/PPARα pathway.

Chen L, Yu S, Hong S, Lin X, Zhu X, Cao X, Li Y, Xiao H
Drug development research 2023 Apr;84(2):156-171

Single-cell transcriptomics uncover the key ferroptosis regulators contribute to cancer progression in head and neck squamous cell carcinoma.

Liu F, Tang L, Li Q, Chen L, Pan Y, Yin Z, He J, Tian J
Frontiers in molecular biosciences 2022;9:962742

Suppressive GLI2 fragment enhances liver metastasis in colorectal cancer.

Ogata R, Mori S, Ohmori H, Kishi S, Fujiwara-Tani R, Sasaki T, Nishiguchi Y, Nakashima C, Goto K, Kawahara I, Luo Y, Kuniyasu H
Oncotarget 2022;13:122-135

Fenofibrate suppresses corneal neovascularization by regulating lipid metabolism through PPARα signaling pathway.

Zhou T, Yan K, Zhang Y, Zhu L, Liao Y, Zheng X, Chen Y, Li X, Liu Z, Zhang Z
Frontiers in pharmacology 2022;13:1000254

Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

Li H, Du Y, Ji H, Yang Y, Xu C, Li Q, Ran L, Wu C, Zhou Q, Wu S
iScience 2022 Nov 18;25(11):105214

Transcriptome Comparison Reveals the Difference in Liver Fat Metabolism between Different Sheep Breeds.

Li T, Jin M, Fei X, Yuan Z, Wang Y, Quan K, Wang T, Yang J, He M, Wei C
Animals : an open access journal from MDPI 2022 Jun 27;12(13)

Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.

Cook JJ, Wei M, Segovia B, Cosio-Lima L, Simpson J, Taylor S, Koh Y, Kim S, Lee Y
Annals of hepatology 2022 Jul-Aug;27(4):100709

Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes.

Chu H, Zhao Q, Liu J, Yang K, Wang Y, Liu J, Zhang K, Zhao B, He H, Zheng Y, Zhong S, Liang Z, Zhang L, Zhang Y
Analytical chemistry 2022 Jan 18;94(2):758-767

N(6)-methyladenosine (m(6)A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation.

Peng H, Chen B, Wei W, Guo S, Han H, Yang C, Ma J, Wang L, Peng S, Kuang M, Lin S
Nature metabolism 2022 Aug;4(8):1041-1054

Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells.

James J, Zemskova M, Eccles CA, Varghese MV, Niihori M, Barker NK, Luo M, Mandarino LJ, Langlais PR, Rafikova O, Rafikov R
Arteriosclerosis, thrombosis, and vascular biology 2021 Feb;41(2):734-754

Heat stress affects fetal brain and intestinal function associated with the alterations of placental barrier in late pregnant mouse.

Guo H, Yang Y, Qiao Y, He J, Yao W, Zheng W
Ecotoxicology and environmental safety 2021 Dec 20;227:112916

Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation.

Cholico GN, Fling RR, Zacharewski NA, Fader KA, Nault R, Zacharewski TR
Scientific reports 2021 Aug 3;11(1):15689

Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation.

Wang W, Hu X, Xia Z, Liu Z, Zhong Z, Lu Z, Liu A, Ye S, Cao Q, Wang Y, Zhu F, Ye Q
Oxidative medicine and cellular longevity 2020;2020:5849794

Effects of canagliflozin on growth and metabolic reprograming in hepatocellular carcinoma cells: Multi-omics analysis of metabolomics and absolute quantification proteomics (iMPAQT).

Nakano D, Kawaguchi T, Iwamoto H, Hayakawa M, Koga H, Torimura T
PloS one 2020;15(4):e0232283

The function of SNHG7/miR-449a/ACSL1 axis in thyroid cancer.

Guo L, Lu J, Gao J, Li M, Wang H, Zhan X
Journal of cellular biochemistry 2020 Oct;121(10):4034-4042

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State.

Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ
Cell chemical biology 2019 Mar 21;26(3):420-432.e9

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.

Zhou L, Wang Z, Hu C, Zhang C, Kovatcheva-Datchary P, Yu D, Liu S, Ren F, Wang X, Li Y, Hou X, Piao H, Lu X, Zhang Y, Xu G
Journal of proteome research 2019 Mar 1;18(3):960-969

Fe(3)O(4)@OA@Poloxamer nanoparticles lower triglyceride in hepatocytes through liposuction effect and nano-enzyme effect.

Sun Y, Shi F, Niu Y, Zhang Y, Xiong F
Colloids and surfaces. B, Biointerfaces 2019 Dec 1;184:110528

Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway.

Wang Q, Cai J, Fang C, Yang C, Zhou J, Tan Y, Wang Y, Li Y, Meng X, Zhao K, Yi K, Zhang S, Zhang J, Jiang C, Zhang J, Kang C
Theranostics 2018;8(17):4733-4749

Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of Hugan Qingzhi on non-alcoholic fatty liver disease in rats.

Yao X, Xia F, Tang W, Xiao C, Yang M, Zhou B
Journal of ethnopharmacology 2018 Feb 15;212:208-215

PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.

Lyu Z, Mao Z, Li Q, Xia Y, Liu Y, He Q, Wang Y, Zhao H, Lu Z, Zhou Q
EBioMedicine 2018 Dec;38:178-190

Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling.

Yang G, Wang Y, Feng J, Liu Y, Wang T, Zhao M, Ye L, Zhang X
Biochemical and biophysical research communications 2017 May 6;486(3):827-832

HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer.

Wang Y, Cai X, Zhang S, Cui M, Liu F, Sun B, Zhang W, Zhang X, Ye L
Biochemical and biophysical research communications 2017 Mar 11;484(3):565-571

Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice.

Wang C, Duan X, Sun X, Liu Z, Sun P, Yang X, Sun H, Liu K, Meng Q
Food & function 2016 Sep 14;7(9):3716-23

Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.

Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX, Wang HY
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86

Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.

Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang X
Cancer research 2015 Mar 1;75(5):846-57

Potent effects of dioscin against obesity in mice.

Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H
Cell reports 2014 Sep 25;8(6):1930-1942

Protective effects of dioscin against alcohol-induced liver injury.

Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53

MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA.

Cui M, Wang Y, Sun B, Xiao Z, Ye L, Zhang X
Biochemical and biophysical research communications 2014 Feb 7;444(2):270-5

Chinese medicine formula lingguizhugan decoction improves Beta-oxidation and metabolism of Fatty Acid in high-fat-diet-induced rat model of Fatty liver disease.

Liu T, Yang LL, Zou L, Li DF, Wen HZ, Zheng PY, Xing LJ, Song HY, Tang XD, Ji G
Evidence-based complementary and alternative medicine : eCAM 2013;2013:429738

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ACSL1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ACSL1. This antibody recognizes human,mouse,rat antigen. The ACSL1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 13989-1-AP.pdf

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