AK4

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Description

Adenylate kinase 4

Tissue specificity

Tissue enhanced (kidney, liver)

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (65147549 - 65232145)

Ensembl ID

ENSG00000162433  (ver. 103.38)

Orthologs

Mouse Ak4: ENSMUSG00000028527

UniProt

P27144

neXtProt

NX_P27144

Human splice variants
Mouse splice variants

Protein structure