BS1900

antibody from Bioworld Technology, Inc
Targeting: ZRANB2 ZIS, ZIS1, ZIS2, ZNF265
Provider product page for BS1900
Western blot
Immunohistochemistry

Antibody data

Product number
BS1900 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ZIS (I144) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 121-170 of Human ZIS.
Description
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2ÉÇ (transformer-2 beta) transcripts and is thought to interfere with constitutive 5£ª-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ZRANB2 protein structure - BS1900 shown in red.