ABIN2841367

antibody from antibodies-online

Targeting: SPHK1 SPHK

Provider product page for ABIN2841367

Western blot

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [3]
Immunohistochemistry [3]

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Product number: ABIN2841367 - Provider product page
Provider: antibodies-online
Product name: anti-Sphingosine Kinase 1 (SPHK1) (AA 286-315), (Center) antibody
Antibody type: Polyclonal
Description: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Reactivity: Human, Mouse, Rat, Simian
Host: Rabbit
Epitope: AA 286-315, Center
Antibody clone number: RB03621
Vial size: 80 μL
Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots.
Handling: Avoid freeze-thaw cycles.

SPHK1 protein structure - ABIN2841367 shown in red.

Submitted references Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia.

Zheng S, Wei S, Wang X, Xu Y, Xiao Y, Liu H, Jia J, Cheng J
Experimental neurology 2015 Oct;272:160-9

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.

Matula K, Collie-Duguid E, Murray G, Parikh K, Grabsch H, Tan P, Lalwani S, Garau R, Ong Y, Bain G, Smith AD, Urquhart G, Bielawski J, Finnegan M, Petty R
BMC cancer 2015 Oct 22;15:762

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.

Dick TE, Hengst JA, Fox TE, Colledge AL, Kale VP, Sung SS, Sharma A, Amin S, Loughran TP Jr, Kester M, Wang HG, Yun JK
The Journal of pharmacology and experimental therapeutics 2015 Mar;352(3):494-508

SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling.

Xiong H, Wang J, Guan H, Wu J, Xu R, Wang M, Rong X, Huang K, Huang J, Liao Q, Fu Y, Yuan J
Oncology reports 2014 Oct;32(4):1369-73

Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice.

Altay O, Suzuki H, Hasegawa Y, Caner B, Krafft PR, Fujii M, Tang J, Zhang JH
Stroke 2012 Sep;43(9):2513-6

Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions.

Fischer I, Alliod C, Martinier N, Newcombe J, Brana C, Pouly S
PloS one 2011;6(8):e23905

Isoflurane activates intestinal sphingosine kinase to protect against bilateral nephrectomy-induced liver and intestine dysfunction.

Kim M, Park SW, Kim M, D'Agati VD, Lee HT
American journal of physiology. Renal physiology 2011 Jan;300(1):F167-76

Isoflurane activates intestinal sphingosine kinase to protect against renal ischemia-reperfusion-induced liver and intestine injury.

Kim M, Park SW, Kim M, D'Agati VD, Lee HT
Anesthesiology 2011 Feb;114(2):363-73

Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-κB pathway in human non-small cell lung cancer.

Song L, Xiong H, Li J, Liao W, Wang L, Wu J, Li M
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Apr 1;17(7):1839-49

Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy.

Liu G, Zheng H, Zhang Z, Wu Z, Xiong H, Li J, Song L
BMC cancer 2010 Sep 16;10:495

Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.

Nayak D, Huo Y, Kwang WX, Pushparaj PN, Kumar SD, Ling EA, Dheen ST
Neuroscience 2010 Mar 10;166(1):132-44

Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients.

Li W, Yu CP, Xia JT, Zhang L, Weng GX, Zheng HQ, Kong QL, Hu LJ, Zeng MS, Zeng YX, Li M, Li J, Song LB
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Feb 15;15(4):1393-9

Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells.

Crousillac S, Colonna J, McMains E, Dewey JS, Gleason E
Journal of neurophysiology 2009 Dec;102(6):3295-309

Differential regulation of sphingosine kinases 1 and 2 in lung injury.

Wadgaonkar R, Patel V, Grinkina N, Romano C, Liu J, Zhao Y, Sammani S, Garcia JG, Natarajan V
American journal of physiology. Lung cellular and molecular physiology 2009 Apr;296(4):L603-13

Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival.

Li J, Guan HY, Gong LY, Song LB, Zhang N, Wu J, Yuan J, Zheng YJ, Huang ZS, Li M
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Nov 1;14(21):6996-7003

Activation of sphingosine kinase-1 mediates inhibition of vascular smooth muscle cell apoptosis by hyperglycemia.

You B, Ren A, Yan G, Sun J
Diabetes 2007 May;56(5):1445-53

FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1.

Sun J, Yan G, Ren A, You B, Liao JK
Circulation research 2006 Sep 1;99(5):468-76

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