Ab090020

antibody from Aladdin Scientific
Targeting: ATG7 APG7L, DKFZp434N0735, GSA7
Provider product page for Ab090020

Antibody data

Product number
Ab090020 - Provider product page
Provider
Aladdin Scientific
Product name
ATG7 Antibody
Antibody type
Polyclonal
Description
RabbitÊanti HumanÊATG7ÊAntibody,ÊPolyclonal, could be used forÊWB, IHC and so on.Application:WB:Ê 1/500-1/1000IHC:Ê1/50-1/100Protein Function:E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 691-703
Vial size
100_l,10_l,1ml,50_l
Concentration
0,6 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
ATG7 protein structure - Ab090020 shown in red.