Ab090020

antibody from Aladdin Scientific Corporation

Targeting: ATG7 APG7L, DKFZp434N0735, GSA7

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab090020

Provider

Aladdin Scientific Corporation

Product name

ATG7 Antibody

Antibody type

Polyclonal

Description

Rabbit anti Human ATG7 Antibody, Polyclonal, could be used for WB, IHC and so on.Application:WB: 1/500-1/1000IHC: 1/50-1/100Protein Function:E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 691-703


Vial size

100μl,10μl,1ml,50μl

Concentration

0,6 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.