AMM03320G

antibody from Leading Biology

Targeting: CARD14 BIMP2, CARMA2, PSORS2

No application information provided.

Antibody Data

Product number

AMM03320G

Provider

Leading Biology

Product name

CARD14 Antibody (monoclonal) (M01)

Antibody type

Monoclonal

Description

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

4B3

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.