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- References [204]
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- Product number
- 600-401-103-0.5 - Provider product page
- Provider
- Rockland Immunochemicals, Inc.
- Proper citation
- Rockland Cat#600-401-103-0.5, RRID:AB_217595
- Product name
- Anti-Collagen Type I (RABBIT) Antibody - 600-401-103-0.5
- Antibody type
- Polyclonal
- Vial size
- 500 µl
Submitted references Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections.
Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis.
Comparison of the Drug-Induced Efficacies between Omidenepag Isopropyl, an EP2 Agonist and PGF2α toward TGF-β2-Modulated Human Trabecular Meshwork (HTM) Cells.
Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells.
Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis.
Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation.
Regeneration of collagen fibrils at the papillary dermis by reconstructing basement membrane at the dermal-epidermal junction.
Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection.
PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis.
Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis.
Myocardin-related transcription factor A regulates integrin beta 2 transcription to promote macrophage infiltration and cardiac hypertrophy in mice.
Immune Regulation of Mammary Fibroblasts and the Impact of Mammographic Density.
Fibrocytes: A Critical Review and Practical Guide.
Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling.
Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system.
The intracellular chloride channel 4 (CLIC4) activates systemic sclerosis fibroblasts.
Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation.
Connexin43 gap junction drives fascia mobilization and repair of deep skin wounds.
Bioprinting a Multifunctional Bioink to Engineer Clickable 3D Cellular Niches with Tunable Matrix Microenvironmental Cues.
Podocyte EGFR Inhibits Autophagy Through Upregulation of Rubicon in Type 2 Diabetic Nephropathy.
Investigating BB0405 as a novel Borrelia afzelii vaccination candidate in Lyme borreliosis.
Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A.
AXL Is a Potential Target for the Treatment of Intestinal Fibrosis.
Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β.
Imaging of type I procollagen biosynthesis in cells reveals biogenesis in highly organized bodies; Collagenosomes.
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
Development of a new decellularization protocol for the whole porcine heart.
CILP1 as a biomarker for right ventricular maladaptation in pulmonary hypertension.
Trabecular meshwork's collagen network formation is inhibited by non-pigmented ciliary epithelium-derived extracellular vesicles.
IL-1β-pre-conditioned mesenchymal stem/stromal cells' secretome modulates the inflammatory response and aggrecan deposition in intervertebral disc.
Activation of TWIST Transcription by Chromatin Remodeling Protein BRG1 Contributes to Liver Fibrosis in Mice.
Effects of ASC Application on Endplate Regeneration Upon Glycerol-Induced Muscle Damage.
YAP Activation in Renal Proximal Tubule Cells Drives Diabetic Renal Interstitial Fibrogenesis.
Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis.
Parenchymal pericytes are not the major contributor of extracellular matrix in the fibrotic scar after stroke in male mice.
Recombinant spider silk protein eADF4(C16)-RGD coatings are suitable for cardiac tissue engineering.
Prostaglandin F2α agonist-induced suppression of 3T3-L1 cell adipogenesis affects spatial formation of extra-cellular matrix.
In vitro analysis of the effect of Flightless I on murine tenocyte cellular functions.
Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids.
Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro.
Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis.
Effects of pirfenidone targeting the tumor microenvironment and tumor-stroma interaction as a novel treatment for non-small cell lung cancer.
Dual roles of chromatin remodeling protein BRG1 in angiotensin II-induced endothelial-mesenchymal transition.
Blockade of Platelet-Derived Growth Factor Signaling Inhibits Choroidal Neovascularization and Subretinal Fibrosis in Mice.
Burn-Induced Impairment of Ileal Muscle Contractility Is Associated with Increased Extracellular Matrix Components.
Microvascular engineering: Dynamic changes in microgel-entrapped vascular cells correlates with higher vasculogenic/angiogenic potential.
Disruption of CXCR6 Ameliorates Kidney Inflammation and Fibrosis in Deoxycorticosterone Acetate/Salt Hypertension.
Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.
CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases.
Systemic Delivery of Anti-Integrin αL Antibodies Reduces Early Macrophage Recruitment, Inflammation, and Scar Formation in Murine Burn Wounds.
Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling.
Phospholipid Polymer Hydrogel Matrices with Dually Immobilized Cytokines for Accelerating Secretion of the Extracellular Matrix by Encapsulated Cells.
Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds.
Increasing the level of cytoskeletal protein Flightless I reduces adhesion formation in a murine digital flexor tendon model.
A Scaffold-Free 3-D Co-Culture Mimics the Major Features of the Reverse Warburg Effect In Vitro.
L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.
The Chromatin Remodeler Brg1 Integrates ROS Production and Endothelial-Mesenchymal Transition to Promote Liver Fibrosis in Mice.
Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression.
Effects of high glucose on proliferation and function of circulating fibrocytes: Involvement of CXCR4/SDF‑1 axis.
The Role of the EGF Receptor in Sex Differences in Kidney Injury.
Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution.
Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor.
Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.
Collagen XIII-derived ectodomain regulates bone angiogenesis and intracortical remodeling.
Smooth Muscle α-Actin Deficiency Leads to Decreased Liver Fibrosis via Impaired Cytoskeletal Signaling in Hepatic Stellate Cells.
Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells.
Mediation of the Acute Stress Response by the Skeleton.
MKL1 promotes endothelial-to-mesenchymal transition and liver fibrosis by activating TWIST1 transcription.
Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout.
Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly.
Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation.
A non-autonomous role of MKL1 in the activation of hepatic stellate cells.
Intra-articularly injected mesenchymal stem cells promote cartilage regeneration, but do not permanently engraft in distant organs.
Mouse placental scaffolds: a three-dimensional environment model for recellularization.
Discovery and evaluation of inhibitor of LARP6 as specific antifibrotic compound.
Clustering, Spatial Distribution, and Phosphorylation of Discoidin Domain Receptors 1 and 2 in Response to Soluble Collagen I.
HIF2A-LOX Pathway Promotes Fibrotic Tissue Remodeling in Thyroid-Associated Orbitopathy.
Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure.
Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue.
Retrospective investigation of the prognostic value of the β1 integrin expression in patients with head and neck squamous cell carcinoma receiving primary radio(chemo)therapy.
Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes.
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis.
Sex steroids drive the remodeling of oviductal extracellular matrix in cattle.
TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration.
Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis.
Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway.
Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control.
Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis.
Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures.
Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway.
Pirfenidone suppresses polarization to M2 phenotype macrophages and the fibrogenic activity of rat lung fibroblasts.
Equine lung decellularization: a potential approach for in vitro modeling the role of the extracellular matrix in asthma.
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Guiding morphogenesis in cell-instructive microgels for therapeutic angiogenesis.
Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes.
Antifibrosis Effect of Novel Oridonin Analog CYD0618 Via Suppression of the NF-κB Pathway.
A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues.
Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors.
Transcription factor 21 (TCF21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells.
Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells.
Sox9 positive periosteal cells in fracture repair of the adult mammalian long bone.
Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model.
HANAC Col4a1 Mutation in Mice Leads to Skeletal Muscle Alterations due to a Primary Vascular Defect.
Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells.
Regeneration of subcutaneous tissue-engineered mandibular condyle in nude mice.
CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome.
An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices.
Dissecting the role of myeloid and mesenchymal fibroblasts in age-dependent cardiac fibrosis.
Altered paracrine signaling from the injured knee joint impairs postnatal long bone growth.
3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs.
mTORC1 phosphorylates LARP6 to stimulate type I collagen expression.
Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer.
IL-4/IL-13-mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury.
Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy.
Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis.
Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.
Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis.
Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis.
p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.
STAT3 Inhibition Suppresses Hepatic Stellate Cell Fibrogenesis: HJC0123, a Potential Therapeutic Agent for Liver Fibrosis.
Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar Lonomia obliqua.
Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study.
Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction.
Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling.
A study to identify and characterize the stem/progenitor cell in rabbit meniscus.
Dynamic remodeling of endometrial extracellular matrix regulates embryo receptivity in cattle.
Surface proteome analysis identifies platelet derived growth factor receptor-alpha as a critical mediator of transforming growth factor-beta-induced collagen secretion.
Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen.
Zoledronic acid suppresses transforming growth factor-β-induced fibrogenesis by human gingival fibroblasts.
COMP-assisted collagen secretion--a novel intracellular function required for fibrosis.
A Bioinspired Ultraporous Nanofiber-Hydrogel Mimic of the Cartilage Extracellular Matrix.
Vitronectin-Based, Biomimetic Encapsulating Hydrogel Scaffolds Support Adipogenesis of Adipose Stem Cells.
β1 Integrins Mediate Attachment of Mesenchymal Stem Cells to Cartilage Lesions.
CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice.
MKL1 is an epigenetic modulator of TGF-β induced fibrogenesis.
Endothelial-to-mesenchymal transition drives atherosclerosis progression.
A novel profibrotic mechanism mediated by TGFβ-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells.
Assessing the accuracy and reproducibility of modality independent elastography in a murine model of breast cancer.
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells.
Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis.
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase.
Interaction of biomechanics with extracellular matrix components in abdominal aortic aneurysm wall.
Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue.
Second-generation compound for the modulation of utrophin in the therapy of DMD.
Long-term type 1 diabetes alters the deposition of collagens and proteoglycans in the early pregnant myometrium of mice.
Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.
Identification of a collagen type I adhesin of Bacteroides fragilis.
Megakaryocytic leukemia 1 (MKL1) regulates hypoxia induced pulmonary hypertension in rats.
3-D adipocyte differentiation and peri-adipocyte collagen turnover.
Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation.
TGF-β2-mediated ocular hypertension is attenuated in SPARC-null mice.
Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis.
Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1.
FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney.
A novel murine model of hypertrophic scarring using subcutaneous infusion of bleomycin.
Stk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity.
miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis.
AMP-activated protein kinase regulates intraocular pressure, extracellular matrix, and cytoskeleton in trabecular meshwork.
Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts.
AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction.
IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver.
The effects of fibrin and fibrin-agarose on the extracellular matrix profile of bioengineered oral mucosa.
Ascorbate enhances elastin synthesis in 3D tissue-engineered pulmonary fibroblasts constructs.
Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury.
CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis.
Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation.
Proteoglycan and collagen expression during human air conducting system development.
Hepatic steatosis, fibrosis, and cancer in elderly cadavers.
Lanthanum carbonate, like sevelamer-HCl, retards the progression of vascular calcification and atherosclerosis in uremic apolipoprotein E-deficient mice.
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway.
High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation.
Globular domain of adiponectin: promising target molecule for detection of atherosclerotic lesions.
Dynamic mechanical stimulations induce anisotropy and improve the tensile properties of engineered tissues produced without exogenous scaffolding.
Coordinated regulation of extracellular matrix synthesis by the microRNA-29 family in the trabecular meshwork.
Calcium concrements in the pineal gland of the Arctic fox (Vulpes lagopus) and their relationship to pinealocytes, glial cells and type I and III collagen fibers.
The effects of aging on the molecular and cellular composition of the prostate microenvironment.
Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum.
Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells.
Characterization of differential properties of rabbit tendon stem cells and tenocytes.
Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes.
Improved serum-free culture conditions for spleen-derived murine fibrocytes.
VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats.
Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria.
Collagen-based fibrous scaffold for spatial organization of encapsulated and seeded human mesenchymal stem cells.
Improved serum-free culture conditions for the differentiation of human and murine fibrocytes.
Adenoviral overexpression and small interfering RNA suppression demonstrate that plasminogen activator inhibitor-1 produces elevated collagen accumulation in normal and keloid fibroblasts.
Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling.
Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation.
Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.
High glucose activates rat pancreatic stellate cells through protein kinase C and p38 mitogen-activated protein kinase pathway.
Site-specific in vivo calcification and osteogenesis stimulated by bone sialoprotein.
The anchorless adhesin Eap (extracellular adherence protein) from Staphylococcus aureus selectively recognizes extracellular matrix aggregates but binds promiscuously to monomeric matrix macromolecules.
Inhibitory effect of dicationic diphenylfurans on production of type I collagen by human fibroblasts and activated hepatic stellate cells.
Adipogenic transcriptional regulation of hepatic stellate cells.
Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells.
TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.
5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo.
Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy.
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.
The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.
Association of the developing acrosome with multiple small Golgi units, the Golgi satellites, in spermatids of the musk shrew, Suncus murinus.
Alhayek A, Khan ES, Schönauer E, Däinghaus T, Shafiei R, Voos K, Han MKL, Ducho C, Posselt G, Wessler S, Brandstetter H, Haupenthal J, Del Campo A, Hirsch AKH
Advanced therapeutics 2022 Mar;5(3):2100222
Advanced therapeutics 2022 Mar;5(3):2100222
Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis.
D'Alessandro-Gabazza CN, Yasuma T, Kobayashi T, Toda M, Abdel-Hamid AM, Fujimoto H, Hataji O, Nakahara H, Takeshita A, Nishihama K, Okano T, Saiki H, Okano Y, Tomaru A, Fridman D'Alessandro V, Shiraishi M, Mizoguchi A, Ono R, Ohtsuka J, Fukumura M, Nosaka T, Mi X, Shukla D, Kataoka K, Kondoh Y, Hirose M, Arai T, Inoue Y, Yano Y, Mackie RI, Cann I, Gabazza EC
Nature communications 2022 Mar 23;13(1):1558
Nature communications 2022 Mar 23;13(1):1558
Comparison of the Drug-Induced Efficacies between Omidenepag Isopropyl, an EP2 Agonist and PGF2α toward TGF-β2-Modulated Human Trabecular Meshwork (HTM) Cells.
Suzuki S, Furuhashi M, Tsugeno Y, Umetsu A, Ida Y, Hikage F, Ohguro H, Watanabe M
Journal of clinical medicine 2022 Mar 16;11(6)
Journal of clinical medicine 2022 Mar 16;11(6)
Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells.
MacDonald WW, Swaminathan SS, Heo JY, Castillejos A, Hsueh J, Liu BJ, Jo D, Du A, Lee H, Kang MH, Rhee DJ
Investigative ophthalmology & visual science 2022 Jun 1;63(6):8
Investigative ophthalmology & visual science 2022 Jun 1;63(6):8
Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis.
Chillappagari S, Schwarz J, Kesireddy V, Knoell J, Korfei M, Hoetzenecker K, Schmitz ML, Behl C, Bellusci S, Guenther A, Mahavadi P
Clinical and translational medicine 2022 Jul;12(7):e935
Clinical and translational medicine 2022 Jul;12(7):e935
Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation.
Castro AL, Ribeiro-Machado C, Oliveira CM, Teixeira GQ, Neidlinger-Wilke C, Pereira P, Vaz R, Barbosa MA, Gonçalves RM
Arthritis research & therapy 2022 Jan 17;24(1):25
Arthritis research & therapy 2022 Jan 17;24(1):25
Regeneration of collagen fibrils at the papillary dermis by reconstructing basement membrane at the dermal-epidermal junction.
Iriyama S, Ogura Y, Nishikawa S, Hosoi J, Amano S
Scientific reports 2022 Jan 17;12(1):795
Scientific reports 2022 Jan 17;12(1):795
Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection.
Nogueira-Rodrigues J, Leite SC, Pinto-Costa R, Sousa SC, Luz LL, Sintra MA, Oliveira R, Monteiro AC, Pinheiro GG, Vitorino M, Silva JA, Simão S, Fernandes VE, Provazník J, Benes V, Cruz CD, Safronov BV, Magalhães A, Reis CA, Vieira J, Vieira CP, Tiscórnia G, Araújo IM, Sousa MM
Developmental cell 2022 Feb 28;57(4):440-450.e7
Developmental cell 2022 Feb 28;57(4):440-450.e7
PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis.
Knoell J, Chillappagari S, Knudsen L, Korfei M, Dartsch R, Jonigk D, Kuehnel MP, Hoetzenecker K, Guenther A, Mahavadi P
Cellular and molecular life sciences : CMLS 2022 Feb 25;79(3):151
Cellular and molecular life sciences : CMLS 2022 Feb 25;79(3):151
Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis.
Sasaki K, Terker AS, Tang J, Cao S, Arroyo JP, Niu A, Wang S, Fan X, Zhang Y, Bennett SR, Zhang MZ, Harris RC
JCI insight 2022 Feb 22;7(4)
JCI insight 2022 Feb 22;7(4)
Myocardin-related transcription factor A regulates integrin beta 2 transcription to promote macrophage infiltration and cardiac hypertrophy in mice.
Liu L, Zhao Q, Kong M, Mao L, Yang Y, Xu Y
Cardiovascular research 2022 Feb 21;118(3):844-858
Cardiovascular research 2022 Feb 21;118(3):844-858
Immune Regulation of Mammary Fibroblasts and the Impact of Mammographic Density.
Archer M, Dasari P, Walsh D, Britt KL, Evdokiou A, Ingman WV
Journal of clinical medicine 2022 Feb 2;11(3)
Journal of clinical medicine 2022 Feb 2;11(3)
Fibrocytes: A Critical Review and Practical Guide.
Reinhardt JW, Breuer CK
Frontiers in immunology 2021;12:784401
Frontiers in immunology 2021;12:784401
Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling.
Li H, Wang Y, Liu J, Chen X, Duan Y, Wang X, Shen Y, Kuang Y, Zhuang T, Tomlinson B, Chan P, Yu Z, Cheng Y, Zhang L, Liu Z, Zhang Y, Zhao Z, Zhang Q, Liu J
Theranostics 2021;11(4):1609-1625
Theranostics 2021;11(4):1609-1625
Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system.
Kostrzewski T, Snow S, Battle AL, Peel S, Ahmad Z, Basak J, Surakala M, Bornot A, Lindgren J, Ryaboshapkina M, Clausen M, Lindén D, Maass C, Young LM, Corrigan A, Ewart L, Hughes D
Communications biology 2021 Sep 15;4(1):1080
Communications biology 2021 Sep 15;4(1):1080
The intracellular chloride channel 4 (CLIC4) activates systemic sclerosis fibroblasts.
Wasson CW, Ross RL, Morton R, Mankouri J, Del Galdo F
Rheumatology (Oxford, England) 2021 Sep 1;60(9):4395-4400
Rheumatology (Oxford, England) 2021 Sep 1;60(9):4395-4400
Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation.
Sasaki K, Terker AS, Pan Y, Li Z, Cao S, Wang Y, Niu A, Wang S, Fan X, Zhang MZ, Harris RC
Journal of the American Society of Nephrology : JASN 2021 May 3;32(5):1037-1052
Journal of the American Society of Nephrology : JASN 2021 May 3;32(5):1037-1052
Connexin43 gap junction drives fascia mobilization and repair of deep skin wounds.
Wan L, Jiang D, Correa-Gallegos D, Ramesh P, Zhao J, Ye H, Zhu S, Wannemacher J, Volz T, Rinkevich Y
Matrix biology : journal of the International Society for Matrix Biology 2021 Mar;97:58-71
Matrix biology : journal of the International Society for Matrix Biology 2021 Mar;97:58-71
Bioprinting a Multifunctional Bioink to Engineer Clickable 3D Cellular Niches with Tunable Matrix Microenvironmental Cues.
Pereira RF, Lourenço BN, Bártolo PJ, Granja PL
Advanced healthcare materials 2021 Jan;10(2):e2001176
Advanced healthcare materials 2021 Jan;10(2):e2001176
Podocyte EGFR Inhibits Autophagy Through Upregulation of Rubicon in Type 2 Diabetic Nephropathy.
Li Y, Pan Y, Cao S, Sasaki K, Wang Y, Niu A, Fan X, Wang S, Zhang MZ, Harris RC
Diabetes 2021 Feb;70(2):562-576
Diabetes 2021 Feb;70(2):562-576
Investigating BB0405 as a novel Borrelia afzelii vaccination candidate in Lyme borreliosis.
Klouwens MJ, Trentelman JJ, Ersoz JI, Nieves Marques Porto F, Sima R, Hajdusek O, Thakur M, Pal U, Hovius JW
Scientific reports 2021 Feb 26;11(1):4775
Scientific reports 2021 Feb 26;11(1):4775
Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A.
Wang D, Rabhi N, Yet SF, Farmer SR, Layne MD
Scientific reports 2021 Feb 17;11(1):3948
Scientific reports 2021 Feb 17;11(1):3948
AXL Is a Potential Target for the Treatment of Intestinal Fibrosis.
Steiner CA, Rodansky ES, Johnson LA, Berinstein JA, Cushing KC, Huang S, Spence JR, Higgins PDR
Inflammatory bowel diseases 2021 Feb 16;27(3):303-316
Inflammatory bowel diseases 2021 Feb 16;27(3):303-316
Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β.
Noskovicova N, Schuster R, van Putten S, Ezzo M, Koehler A, Boo S, Coelho NM, Griggs D, Ruminski P, McCulloch CA, Hinz B
Nature biomedical engineering 2021 Dec;5(12):1437-1456
Nature biomedical engineering 2021 Dec;5(12):1437-1456
Imaging of type I procollagen biosynthesis in cells reveals biogenesis in highly organized bodies; Collagenosomes.
Stefanovic B, Stefanovic L, Manojlovic Z
Matrix biology plus 2021 Dec;12:100076
Matrix biology plus 2021 Dec;12:100076
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
Gerckens M, Schorpp K, Pelizza F, Wögrath M, Reichau K, Ma H, Dworsky AM, Sengupta A, Stoleriu MG, Heinzelmann K, Merl-Pham J, Irmler M, Alsafadi HN, Trenkenschuh E, Sarnova L, Jirouskova M, Frieß W, Hauck SM, Beckers J, Kneidinger N, Behr J, Hilgendorff A, Hadian K, Lindner M, Königshoff M, Eickelberg O, Gregor M, Plettenburg O, Yildirim AÖ, Burgstaller G
Science advances 2021 Dec 24;7(52):eabb3673
Science advances 2021 Dec 24;7(52):eabb3673
Development of a new decellularization protocol for the whole porcine heart.
Delgado ALJ, Carreira ACO, de Carvalho HJC, da Palma RK, Sasahara THC, de Carvalho CMF, León M, Barreto RDSN, Miglino MA
Journal of clinical and translational research 2021 Aug 26;7(4):563-574
Journal of clinical and translational research 2021 Aug 26;7(4):563-574
CILP1 as a biomarker for right ventricular maladaptation in pulmonary hypertension.
Keranov S, Dörr O, Jafari L, Troidl C, Liebetrau C, Kriechbaum S, Keller T, Voss S, Bauer T, Lorenz J, Richter MJ, Tello K, Gall H, Ghofrani HA, Mayer E, Wiedenroth CB, Guth S, Lörchner H, Pöling J, Chelladurai P, Pullamsetti SS, Braun T, Seeger W, Hamm CW, Nef H
The European respiratory journal 2021 Apr;57(4)
The European respiratory journal 2021 Apr;57(4)
Trabecular meshwork's collagen network formation is inhibited by non-pigmented ciliary epithelium-derived extracellular vesicles.
Tabak S, Schreiber-Avissar S, Beit-Yannai E
Journal of cellular and molecular medicine 2021 Apr;25(7):3339-3347
Journal of cellular and molecular medicine 2021 Apr;25(7):3339-3347
IL-1β-pre-conditioned mesenchymal stem/stromal cells' secretome modulates the inflammatory response and aggrecan deposition in intervertebral disc.
Ferreira JR, Teixeira GQ, Neto E, Ribeiro-Machado C, Silva AM, Caldeira J, Leite Pereira C, Bidarra S, Maia AF, Lamghari M, Barbosa MA, Gonçalves RM
European cells & materials 2021 Apr 20;41:431-453
European cells & materials 2021 Apr 20;41:431-453
Activation of TWIST Transcription by Chromatin Remodeling Protein BRG1 Contributes to Liver Fibrosis in Mice.
Dong W, Kong M, Zhu Y, Shao Y, Wu D, Lu J, Guo J, Xu Y
Frontiers in cell and developmental biology 2020;8:340
Frontiers in cell and developmental biology 2020;8:340
Effects of ASC Application on Endplate Regeneration Upon Glycerol-Induced Muscle Damage.
Rigon M, Hörner SJ, Straka T, Bieback K, Gretz N, Hafner M, Rudolf R
Frontiers in molecular neuroscience 2020;13:107
Frontiers in molecular neuroscience 2020;13:107
YAP Activation in Renal Proximal Tubule Cells Drives Diabetic Renal Interstitial Fibrogenesis.
Chen J, Wang X, He Q, Bulus N, Fogo AB, Zhang MZ, Harris RC
Diabetes 2020 Nov;69(11):2446-2457
Diabetes 2020 Nov;69(11):2446-2457
Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis.
Tiwari A, Tashiro K, Dixit A, Soni A, Vogel K, Hall B, Shafqat I, Slaughter J, Param N, Le A, Saunders E, Paithane U, Garcia G, Campos AR, Zettervall J, Carlson M, Starr TK, Marahrens Y, Deshpande AJ, Commisso C, Provenzano PP, Bagchi A
Gastroenterology 2020 Nov;159(5):1882-1897.e5
Gastroenterology 2020 Nov;159(5):1882-1897.e5
Parenchymal pericytes are not the major contributor of extracellular matrix in the fibrotic scar after stroke in male mice.
Roth M, Enström A, Aghabeick C, Carlsson R, Genové G, Paul G
Journal of neuroscience research 2020 May;98(5):826-842
Journal of neuroscience research 2020 May;98(5):826-842
Recombinant spider silk protein eADF4(C16)-RGD coatings are suitable for cardiac tissue engineering.
Kramer JPM, Aigner TB, Petzold J, Roshanbinfar K, Scheibel T, Engel FB
Scientific reports 2020 May 29;10(1):8789
Scientific reports 2020 May 29;10(1):8789
Prostaglandin F2α agonist-induced suppression of 3T3-L1 cell adipogenesis affects spatial formation of extra-cellular matrix.
Ida Y, Hikage F, Itoh K, Ida H, Ohguro H
Scientific reports 2020 May 14;10(1):7958
Scientific reports 2020 May 14;10(1):7958
In vitro analysis of the effect of Flightless I on murine tenocyte cellular functions.
Jackson JE, Kopecki Z, Anderson PJ, Cowin AJ
Journal of orthopaedic surgery and research 2020 May 12;15(1):170
Journal of orthopaedic surgery and research 2020 May 12;15(1):170
Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids.
Kumar Gupta A, Sarkar P, Wertheim JA, Pan X, Carroll TJ, Oxburgh L
Communications biology 2020 May 11;3(1):231
Communications biology 2020 May 11;3(1):231
Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro.
Khan ES, Sankaran S, Llontop L, Del Campo A
BMC molecular and cell biology 2020 Mar 30;21(1):22
BMC molecular and cell biology 2020 Mar 30;21(1):22
Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis.
Shi Z, Ren M, Rockey DC
American journal of physiology. Gastrointestinal and liver physiology 2020 Mar 1;318(3):G504-G517
American journal of physiology. Gastrointestinal and liver physiology 2020 Mar 1;318(3):G504-G517
Effects of pirfenidone targeting the tumor microenvironment and tumor-stroma interaction as a novel treatment for non-small cell lung cancer.
Fujiwara A, Funaki S, Fukui E, Kimura K, Kanou T, Ose N, Minami M, Shintani Y
Scientific reports 2020 Jul 2;10(1):10900
Scientific reports 2020 Jul 2;10(1):10900
Dual roles of chromatin remodeling protein BRG1 in angiotensin II-induced endothelial-mesenchymal transition.
Li Z, Kong X, Zhang Y, Zhang Y, Yu L, Guo J, Xu Y
Cell death & disease 2020 Jul 18;11(7):549
Cell death & disease 2020 Jul 18;11(7):549
Blockade of Platelet-Derived Growth Factor Signaling Inhibits Choroidal Neovascularization and Subretinal Fibrosis in Mice.
Liu Y, Noda K, Murata M, Wu D, Kanda A, Ishida S
Journal of clinical medicine 2020 Jul 15;9(7)
Journal of clinical medicine 2020 Jul 15;9(7)
Burn-Induced Impairment of Ileal Muscle Contractility Is Associated with Increased Extracellular Matrix Components.
Cummins CB, Gu Y, Wang X, Lin YM, Shi XZ, Radhakrishnan RS
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2020 Jan;24(1):188-197
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2020 Jan;24(1):188-197
Microvascular engineering: Dynamic changes in microgel-entrapped vascular cells correlates with higher vasculogenic/angiogenic potential.
Torres AL, Bidarra SJ, Vasconcelos DP, Barbosa JN, Silva EA, Nascimento DS, Barrias CC
Biomaterials 2020 Jan;228:119554
Biomaterials 2020 Jan;228:119554
Disruption of CXCR6 Ameliorates Kidney Inflammation and Fibrosis in Deoxycorticosterone Acetate/Salt Hypertension.
Wu Y, An C, Jin X, Hu Z, Wang Y
Scientific reports 2020 Jan 10;10(1):133
Scientific reports 2020 Jan 10;10(1):133
Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.
Ho LTY, Osterwald A, Ruf I, Hunziker D, Mattei P, Challa P, Vann R, Ullmer C, Rao PV
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165560
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165560
CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases.
Greiffo FR, Viteri-Alvarez V, Frankenberger M, Dietel D, Ortega-Gomez A, Lee JS, Hilgendorff A, Behr J, Soehnlein O, Eickelberg O, Fernandez IE
The European respiratory journal 2020 Feb;55(2)
The European respiratory journal 2020 Feb;55(2)
Systemic Delivery of Anti-Integrin αL Antibodies Reduces Early Macrophage Recruitment, Inflammation, and Scar Formation in Murine Burn Wounds.
Strudwick XL, Adams DH, Pyne NT, Samuel MS, Murray RZ, Cowin AJ
Advances in wound care 2020 Dec;9(12):637-648
Advances in wound care 2020 Dec;9(12):637-648
Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling.
Dantas WS, Roschel H, Murai IH, Gil S, Davuluri G, Axelrod CL, Ghosh S, Newman SS, Zhang H, Shinjo SK, das Neves W, Merege-Filho C, Teodoro WR, Capelozzi VL, Pereira RM, Benatti FB, de Sá-Pinto AL, de Cleva R, Santo MA, Kirwan JP, Gualano B
Diabetes 2020 Aug;69(8):1675-1691
Diabetes 2020 Aug;69(8):1675-1691
Phospholipid Polymer Hydrogel Matrices with Dually Immobilized Cytokines for Accelerating Secretion of the Extracellular Matrix by Encapsulated Cells.
Zhang R, Teramura Y, Fukazawa K, Ishihara K
Macromolecular bioscience 2020 Aug;20(8):e2000114
Macromolecular bioscience 2020 Aug;20(8):e2000114
Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds.
Thomas HM, Ahangar P, Hofma BR, Strudwick XL, Fitridge R, Mills SJ, Cowin AJ
International journal of molecular sciences 2020 Aug 5;21(16)
International journal of molecular sciences 2020 Aug 5;21(16)
Increasing the level of cytoskeletal protein Flightless I reduces adhesion formation in a murine digital flexor tendon model.
Jackson JE, Kopecki Z, Anderson PJ, Cowin AJ
Journal of orthopaedic surgery and research 2020 Aug 27;15(1):362
Journal of orthopaedic surgery and research 2020 Aug 27;15(1):362
A Scaffold-Free 3-D Co-Culture Mimics the Major Features of the Reverse Warburg Effect In Vitro.
Keller F, Bruch R, Schneider R, Meier-Hubberten J, Hafner M, Rudolf R
Cells 2020 Aug 13;9(8)
Cells 2020 Aug 13;9(8)
L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.
Drescher HK, Schippers A, Rosenhain S, Gremse F, Bongiovanni L, Bruin A, Eswaran S, Gallage SU, Pfister D, Szydlowska M, Heikenwalder M, Weiskirchen S, Wagner N, Trautwein C, Weiskirchen R, Kroy DC
Cells 2020 Apr 29;9(5)
Cells 2020 Apr 29;9(5)
The Chromatin Remodeler Brg1 Integrates ROS Production and Endothelial-Mesenchymal Transition to Promote Liver Fibrosis in Mice.
Li Z, Chen B, Dong W, Kong M, Shao Y, Fan Z, Yu L, Wu D, Lu J, Guo J, Xu Y
Frontiers in cell and developmental biology 2019;7:245
Frontiers in cell and developmental biology 2019;7:245
Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression.
Yang J, Wang B, Li N, Zhou Q, Zhou W, Zhan Z
Evidence-based complementary and alternative medicine : eCAM 2019;2019:6479136
Evidence-based complementary and alternative medicine : eCAM 2019;2019:6479136
Effects of high glucose on proliferation and function of circulating fibrocytes: Involvement of CXCR4/SDF‑1 axis.
Weng Y, Lou J, Liu X, Lin S, Xu C, Du C, Tang L
International journal of molecular medicine 2019 Sep;44(3):927-938
International journal of molecular medicine 2019 Sep;44(3):927-938
The Role of the EGF Receptor in Sex Differences in Kidney Injury.
Zhang MZ, Sasaki K, Li Y, Li Z, Pan Y, Jin GN, Wang Y, Niu A, Wang S, Fan X, Chen JC, Borza C, Yang H, Pozzi A, Fogo AB, Harris RC
Journal of the American Society of Nephrology : JASN 2019 Sep;30(9):1659-1673
Journal of the American Society of Nephrology : JASN 2019 Sep;30(9):1659-1673
Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution.
Rajaram RD, Dissard R, Faivre A, Ino F, Delitsikou V, Jaquet V, Cagarelli T, Lindenmeyer M, Jansen-Duerr P, Cohen C, Moll S, de Seigneux S
Redox biology 2019 Sep;26:101234
Redox biology 2019 Sep;26:101234
Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor.
Liu Y, Kanda A, Wu D, Ishizuka ET, Kase S, Noda K, Ichihara A, Ishida S
Molecular therapy. Nucleic acids 2019 Sep 6;17:113-125
Molecular therapy. Nucleic acids 2019 Sep 6;17:113-125
Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.
Ashok A, Kang MH, Wise AS, Pattabiraman P, Johnson WM, Lonigro M, Ravikumar R, Rhee DJ, Singh N
Scientific reports 2019 Sep 11;9(1):13090
Scientific reports 2019 Sep 11;9(1):13090
Collagen XIII-derived ectodomain regulates bone angiogenesis and intracortical remodeling.
Koivunen J, Kemppainen AV, Finnilä MA, Keski-Filppula R, Härönen H, Tu H, Pellikka H, Heikkinen A, Kylmäoja E, Sormunen R, Miinalainen I, Saarakkala S, Izzi V, Pihlajaniemi T
Matrix biology : journal of the International Society for Matrix Biology 2019 Oct;83:6-25
Matrix biology : journal of the International Society for Matrix Biology 2019 Oct;83:6-25
Smooth Muscle α-Actin Deficiency Leads to Decreased Liver Fibrosis via Impaired Cytoskeletal Signaling in Hepatic Stellate Cells.
Rockey DC, Du Q, Weymouth ND, Shi Z
The American journal of pathology 2019 Nov;189(11):2209-2220
The American journal of pathology 2019 Nov;189(11):2209-2220
Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells.
Nettesheim A, Shim MS, Hirt J, Liton PB
Scientific reports 2019 Nov 6;9(1):16092
Scientific reports 2019 Nov 6;9(1):16092
Mediation of the Acute Stress Response by the Skeleton.
Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, Horvath TL, Domingos AI, Marsland AL, Yadav VK, Rahmouni K, Gao XB, Karsenty G
Cell metabolism 2019 Nov 5;30(5):890-902.e8
Cell metabolism 2019 Nov 5;30(5):890-902.e8
MKL1 promotes endothelial-to-mesenchymal transition and liver fibrosis by activating TWIST1 transcription.
Li Z, Chen B, Dong W, Kong M, Fan Z, Yu L, Wu D, Lu J, Xu Y
Cell death & disease 2019 Nov 27;10(12):899
Cell death & disease 2019 Nov 27;10(12):899
Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout.
Fujii KK, Taga Y, Sakai T, Ito S, Hattori S, Nagata K, Koide T
Scientific reports 2019 Nov 22;9(1):17433
Scientific reports 2019 Nov 22;9(1):17433
Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly.
Khan ES, Sankaran S, Paez JI, Muth C, Han MKL, Del Campo A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2019 May 3;6(9):1801982
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2019 May 3;6(9):1801982
Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation.
Han Y, Feng H, Sun J, Liang X, Wang Z, Xing W, Dai Q, Yang Y, Han A, Wei Z, Bi Q, Ji H, Kang T, Zou W
The Journal of clinical investigation 2019 May 1;129(5):1895-1909
The Journal of clinical investigation 2019 May 1;129(5):1895-1909
A non-autonomous role of MKL1 in the activation of hepatic stellate cells.
Li Z, Li P, Lu Y, Sun D, Zhang X, Xu Y
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Jun;1862(6):609-618
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Jun;1862(6):609-618
Intra-articularly injected mesenchymal stem cells promote cartilage regeneration, but do not permanently engraft in distant organs.
Satué M, Schüler C, Ginner N, Erben RG
Scientific reports 2019 Jul 12;9(1):10153
Scientific reports 2019 Jul 12;9(1):10153
Mouse placental scaffolds: a three-dimensional environment model for recellularization.
Barreto RS, Romagnolli P, Fratini P, Mess AM, Miglino MA
Journal of tissue engineering 2019 Jan-Dec;10:2041731419867962
Journal of tissue engineering 2019 Jan-Dec;10:2041731419867962
Discovery and evaluation of inhibitor of LARP6 as specific antifibrotic compound.
Stefanovic B, Manojlovic Z, Vied C, Badger CD, Stefanovic L
Scientific reports 2019 Jan 23;9(1):326
Scientific reports 2019 Jan 23;9(1):326
Clustering, Spatial Distribution, and Phosphorylation of Discoidin Domain Receptors 1 and 2 in Response to Soluble Collagen I.
Yeung DA, Shanker N, Sohail A, Weiss BA, Wang C, Wellmerling J, Das S, Ganju RK, Miller JLC, Herr AB, Fridman R, Agarwal G
Journal of molecular biology 2019 Jan 18;431(2):368-390
Journal of molecular biology 2019 Jan 18;431(2):368-390
HIF2A-LOX Pathway Promotes Fibrotic Tissue Remodeling in Thyroid-Associated Orbitopathy.
Hikage F, Atkins S, Kahana A, Smith TJ, Chun TH
Endocrinology 2019 Jan 1;160(1):20-35
Endocrinology 2019 Jan 1;160(1):20-35
Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure.
Verjans R, Derks WJA, Korn K, Sönnichsen B, van Leeuwen REW, Schroen B, van Bilsen M, Heymans S
Scientific reports 2019 Apr 15;9(1):6055
Scientific reports 2019 Apr 15;9(1):6055
Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue.
Jager M, Lee MJ, Li C, Farmer SR, Fried SK, Layne MD
PloS one 2018;13(5):e0197777
PloS one 2018;13(5):e0197777
Retrospective investigation of the prognostic value of the β1 integrin expression in patients with head and neck squamous cell carcinoma receiving primary radio(chemo)therapy.
Cordes N, Ney M, Beleites T, Aust D, Baretton G, Thames H, Baumann M, Krause M, Löck S, Appold S
PloS one 2018;13(12):e0209479
PloS one 2018;13(12):e0209479
Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes.
Li Z, Li Y, Overstreet JM, Chung S, Niu A, Fan X, Wang S, Wang Y, Zhang MZ, Harris RC
Diabetes 2018 Sep;67(9):1847-1857
Diabetes 2018 Sep;67(9):1847-1857
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis.
Lehmann M, Buhl L, Alsafadi HN, Klee S, Hermann S, Mutze K, Ota C, Lindner M, Behr J, Hilgendorff A, Wagner DE, Königshoff M
Respiratory research 2018 Sep 15;19(1):175
Respiratory research 2018 Sep 15;19(1):175
Sex steroids drive the remodeling of oviductal extracellular matrix in cattle.
Gonella-Diaza AM, Silveira Mesquita F, Lopes E, Ribeiro da Silva K, Cogliati B, De Francisco Strefezzi R, Binelli M
Biology of reproduction 2018 Sep 1;99(3):590-599
Biology of reproduction 2018 Sep 1;99(3):590-599
TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration.
Chung S, Overstreet JM, Li Y, Wang Y, Niu A, Wang S, Fan X, Sasaki K, Jin GN, Khodo SN, Gewin L, Zhang MZ, Harris RC
JCI insight 2018 Nov 2;3(21)
JCI insight 2018 Nov 2;3(21)
Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis.
Heinzelmann K, Lehmann M, Gerckens M, Noskovičová N, Frankenberger M, Lindner M, Hatz R, Behr J, Hilgendorff A, Königshoff M, Eickelberg O
American journal of physiology. Lung cellular and molecular physiology 2018 Nov 1;315(5):L682-L696
American journal of physiology. Lung cellular and molecular physiology 2018 Nov 1;315(5):L682-L696
Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway.
Cummins CB, Wang X, Nunez Lopez O, Graham G, Tie HY, Zhou J, Radhakrishnan RS
International journal of molecular sciences 2018 May 24;19(6)
International journal of molecular sciences 2018 May 24;19(6)
Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control.
Li Y, Chung S, Li Z, Overstreet JM, Gagnon L, Grouix B, Leduc M, Laurin P, Zhang MZ, Harris RC
JCI insight 2018 May 17;3(10)
JCI insight 2018 May 17;3(10)
Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis.
Lin JZ, Rabhi N, Farmer SR
Cell reports 2018 May 15;23(7):1977-1987
Cell reports 2018 May 15;23(7):1977-1987
Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures.
Burgstaller G, Sengupta A, Vierkotten S, Preissler G, Lindner M, Behr J, Königshoff M, Eickelberg O
American journal of physiology. Lung cellular and molecular physiology 2018 May 1;314(5):L708-L723
American journal of physiology. Lung cellular and molecular physiology 2018 May 1;314(5):L708-L723
Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
Noskovičová N, Heinzelmann K, Burgstaller G, Behr J, Eickelberg O
American journal of physiology. Lung cellular and molecular physiology 2018 May 1;314(5):L695-L707
American journal of physiology. Lung cellular and molecular physiology 2018 May 1;314(5):L695-L707
Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway.
Ohmaru-Nakanishi T, Asanoma K, Fujikawa M, Fujita Y, Yagi H, Onoyama I, Hidaka N, Sonoda K, Kato K
The American journal of pathology 2018 Mar;188(3):683-695
The American journal of pathology 2018 Mar;188(3):683-695
Pirfenidone suppresses polarization to M2 phenotype macrophages and the fibrogenic activity of rat lung fibroblasts.
Toda M, Mizuguchi S, Minamiyama Y, Yamamoto-Oka H, Aota T, Kubo S, Nishiyama N, Shibata T, Takemura S
Journal of clinical biochemistry and nutrition 2018 Jul;63(1):58-65
Journal of clinical biochemistry and nutrition 2018 Jul;63(1):58-65
Equine lung decellularization: a potential approach for in vitro modeling the role of the extracellular matrix in asthma.
da Palma RK, Fratini P, Schiavo Matias GS, Cereta AD, Guimarães LL, Anunciação ARA, de Oliveira LVF, Farre R, Miglino MA
Journal of tissue engineering 2018 Jan-Dec;9:2041731418810164
Journal of tissue engineering 2018 Jan-Dec;9:2041731418810164
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Wu X, Dao Thi VL, Huang Y, Billerbeck E, Saha D, Hoffmann HH, Wang Y, Silva LAV, Sarbanes S, Sun T, Andrus L, Yu Y, Quirk C, Li M, MacDonald MR, Schneider WM, An X, Rosenberg BR, Rice CM
Cell 2018 Jan 25;172(3):423-438.e25
Cell 2018 Jan 25;172(3):423-438.e25
Guiding morphogenesis in cell-instructive microgels for therapeutic angiogenesis.
Torres AL, Bidarra SJ, Pinto MT, Aguiar PC, Silva EA, Barrias CC
Biomaterials 2018 Feb;154:34-47
Biomaterials 2018 Feb;154:34-47
Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes.
Shukunami C, Takimoto A, Nishizaki Y, Yoshimoto Y, Tanaka S, Miura S, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y
Scientific reports 2018 Feb 16;8(1):3155
Scientific reports 2018 Feb 16;8(1):3155
Antifibrosis Effect of Novel Oridonin Analog CYD0618 Via Suppression of the NF-κB Pathway.
Cummins CB, Wang X, Xu J, Hughes BD, Ding Y, Chen H, Zhou J, Radhakrishnan RS
The Journal of surgical research 2018 Dec;232:283-292
The Journal of surgical research 2018 Dec;232:283-292
A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues.
Laternser S, Keller H, Leupin O, Rausch M, Graf-Hausner U, Rimann M
SLAS technology 2018 Dec;23(6):599-613
SLAS technology 2018 Dec;23(6):599-613
Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors.
Cieslik KA, Sekhar RV, Granillo A, Reddy A, Medrano G, Heredia CP, Entman ML, Hamilton DJ, Li S, Reineke E, Gupte AA, Zhang A, Taffet GE
The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Aug 10;73(9):1167-1177
The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Aug 10;73(9):1167-1177
Transcription factor 21 (TCF21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells.
Akama T, Chun TH
The Journal of biological chemistry 2018 Apr 27;293(17):6603-6610
The Journal of biological chemistry 2018 Apr 27;293(17):6603-6610
Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells.
Ho LTY, Skiba N, Ullmer C, Rao PV
Investigative ophthalmology & visual science 2018 Apr 1;59(5):1969-1984
Investigative ophthalmology & visual science 2018 Apr 1;59(5):1969-1984
Sox9 positive periosteal cells in fracture repair of the adult mammalian long bone.
He X, Bougioukli S, Ortega B, Arevalo E, Lieberman JR, McMahon AP
Bone 2017 Oct;103:12-19
Bone 2017 Oct;103:12-19
Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model.
Zhang MZ, Wang X, Yang H, Fogo AB, Murphy BJ, Kaltenbach R, Cheng P, Zinker B, Harris RC
Journal of the American Society of Nephrology : JASN 2017 Nov;28(11):3300-3311
Journal of the American Society of Nephrology : JASN 2017 Nov;28(11):3300-3311
HANAC Col4a1 Mutation in Mice Leads to Skeletal Muscle Alterations due to a Primary Vascular Defect.
Guiraud S, Migeon T, Ferry A, Chen Z, Ouchelouche S, Verpont MC, Sado Y, Allamand V, Ronco P, Plaisier E
The American journal of pathology 2017 Mar;187(3):505-516
The American journal of pathology 2017 Mar;187(3):505-516
Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells.
Hicks DF, Goossens N, Blas-García A, Tsuchida T, Wooden B, Wallace MC, Nieto N, Lade A, Redhead B, Cederbaum AI, Dudley JT, Fuchs BC, Lee YA, Hoshida Y, Friedman SL
Scientific reports 2017 Mar 3;7:42563
Scientific reports 2017 Mar 3;7:42563
Regeneration of subcutaneous tissue-engineered mandibular condyle in nude mice.
Wang F, Hu Y, He D, Zhou G, Yang X, Ellis E 3rd
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2017 Jun;45(6):855-861
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2017 Jun;45(6):855-861
CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome.
Bürgi J, Kunz B, Abrami L, Deuquet J, Piersigilli A, Scholl-Bürgi S, Lausch E, Unger S, Superti-Furga A, Bonaldo P, van der Goot FG
Nature communications 2017 Jun 12;8:15861
Nature communications 2017 Jun 12;8:15861
An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices.
Alsafadi HN, Staab-Weijnitz CA, Lehmann M, Lindner M, Peschel B, Königshoff M, Wagner DE
American journal of physiology. Lung cellular and molecular physiology 2017 Jun 1;312(6):L896-L902
American journal of physiology. Lung cellular and molecular physiology 2017 Jun 1;312(6):L896-L902
Dissecting the role of myeloid and mesenchymal fibroblasts in age-dependent cardiac fibrosis.
Trial J, Heredia CP, Taffet GE, Entman ML, Cieslik KA
Basic research in cardiology 2017 Jul;112(4):34
Basic research in cardiology 2017 Jul;112(4):34
Altered paracrine signaling from the injured knee joint impairs postnatal long bone growth.
Roselló-Díez A, Stephen D, Joyner AL
eLife 2017 Jul 25;6
eLife 2017 Jul 25;6
3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs.
Surolia R, Li FJ, Wang Z, Li H, Liu G, Zhou Y, Luckhardt T, Bae S, Liu RM, Rangarajan S, de Andrade J, Thannickal VJ, Antony VB
JCI insight 2017 Jan 26;2(2):e91377
JCI insight 2017 Jan 26;2(2):e91377
mTORC1 phosphorylates LARP6 to stimulate type I collagen expression.
Zhang Y, Stefanovic B
Scientific reports 2017 Jan 23;7:41173
Scientific reports 2017 Jan 23;7:41173
Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer.
Yang Z, Peng YC, Gopalan A, Gao D, Chen Y, Joyner AL
Disease models & mechanisms 2017 Jan 1;10(1):39-52
Disease models & mechanisms 2017 Jan 1;10(1):39-52
IL-4/IL-13-mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury.
Zhang MZ, Wang X, Wang Y, Niu A, Wang S, Zou C, Harris RC
Kidney international 2017 Feb;91(2):375-386
Kidney international 2017 Feb;91(2):375-386
Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy.
Wang X, Yao B, Wang Y, Fan X, Wang S, Niu A, Yang H, Fogo A, Zhang MZ, Harris RC
Diabetes 2017 Feb;66(2):494-504
Diabetes 2017 Feb;66(2):494-504
Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis.
Hofmann K, Fiedler S, Vierkotten S, Weber J, Klee S, Jia J, Zwickenpflug W, Flockerzi V, Storch U, Yildirim AÖ, Gudermann T, Königshoff M, Dietrich A
Biochimica et biophysica acta. Molecular basis of disease 2017 Feb;1863(2):560-568
Biochimica et biophysica acta. Molecular basis of disease 2017 Feb;1863(2):560-568
Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.
El Agha E, Moiseenko A, Kheirollahi V, De Langhe S, Crnkovic S, Kwapiszewska G, Szibor M, Kosanovic D, Schwind F, Schermuly RT, Henneke I, MacKenzie B, Quantius J, Herold S, Ntokou A, Ahlbrecht K, Braun T, Morty RE, Günther A, Seeger W, Bellusci S
Cell stem cell 2017 Feb 2;20(2):261-273.e3
Cell stem cell 2017 Feb 2;20(2):261-273.e3
Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis.
Maekawa T, Osawa Y, Izumi T, Nagao S, Takano K, Okada Y, Tachi N, Teramoto M, Kawamura T, Horiuchi T, Saga R, Kato S, Yamamura T, Watanabe J, Kobayashi A, Kobayashi S, Sato K, Hashimoto M, Suzu S, Kimura F
Leukemia 2017 Dec;31(12):2709-2716
Leukemia 2017 Dec;31(12):2709-2716
Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis.
Murray LA, Habiel DM, Hohmann M, Camelo A, Shang H, Zhou Y, Coelho AL, Peng X, Gulati M, Crestani B, Sleeman MA, Mustelin T, Moore MW, Ryu C, Osafo-Addo AD, Elias JA, Lee CG, Hu B, Herazo-Maya JD, Knight DA, Hogaboam CM, Herzog EL
JCI insight 2017 Aug 17;2(16)
JCI insight 2017 Aug 17;2(16)
p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.
Yosef R, Pilpel N, Papismadov N, Gal H, Ovadya Y, Vadai E, Miller S, Porat Z, Ben-Dor S, Krizhanovsky V
The EMBO journal 2017 Aug 1;36(15):2280-2295
The EMBO journal 2017 Aug 1;36(15):2280-2295
STAT3 Inhibition Suppresses Hepatic Stellate Cell Fibrogenesis: HJC0123, a Potential Therapeutic Agent for Liver Fibrosis.
Nunez Lopez O, Bohanon FJ, Wang X, Ye N, Corsello T, Rojas-Khalil Y, Chen H, Chen H, Zhou J, Radhakrishnan RS
RSC advances 2016;6(102):100652-100663
RSC advances 2016;6(102):100652-100663
Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar Lonomia obliqua.
Sato AC, Bosch RV, Will SE, Alvarez-Flores MP, Goldfeder MB, Pasqualoto KF, da Silva BA, de Andrade SA, Chudzinski-Tavassi AM
The journal of venomous animals and toxins including tropical diseases 2016;22:36
The journal of venomous animals and toxins including tropical diseases 2016;22:36
Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study.
Pirhonen J, Arola J, Sädevirta S, Luukkonen P, Karppinen SM, Pihlajaniemi T, Isomäki A, Hukkanen M, Yki-Järvinen H, Ikonen E
PloS one 2016;11(1):e0147804
PloS one 2016;11(1):e0147804
Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction.
Yariswamy M, Yoshida T, Valente AJ, Kandikattu HK, Sakamuri SS, Siddesha JM, Sukhanov S, Saifudeen Z, Ma L, Siebenlist U, Gardner JD, Chandrasekar B
The Journal of biological chemistry 2016 Sep 9;291(37):19425-36
The Journal of biological chemistry 2016 Sep 9;291(37):19425-36
Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling.
Pereira CL, Teixeira GQ, Ribeiro-Machado C, Caldeira J, Costa M, Figueiredo F, Fernandes R, Aguiar P, Grad S, Barbosa MA, Gonçalves RM
Scientific reports 2016 Sep 22;6:33836
Scientific reports 2016 Sep 22;6:33836
A study to identify and characterize the stem/progenitor cell in rabbit meniscus.
Huang H, Wang S, Gui J, Shen H
Cytotechnology 2016 Oct;68(5):2083-103
Cytotechnology 2016 Oct;68(5):2083-103
Dynamic remodeling of endometrial extracellular matrix regulates embryo receptivity in cattle.
Scolari SC, Pugliesi G, Strefezzi RF, Andrade SC, Coutinho LL, Binelli M
Reproduction (Cambridge, England) 2016 Oct 17;
Reproduction (Cambridge, England) 2016 Oct 17;
Surface proteome analysis identifies platelet derived growth factor receptor-alpha as a critical mediator of transforming growth factor-beta-induced collagen secretion.
Heinzelmann K, Noskovičová N, Merl-Pham J, Preissler G, Winter H, Lindner M, Hatz R, Hauck SM, Behr J, Eickelberg O
The international journal of biochemistry & cell biology 2016 May;74:44-59
The international journal of biochemistry & cell biology 2016 May;74:44-59
Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen.
Zhang Y, Stefanovic B
Scientific reports 2016 Mar 2;6:22597
Scientific reports 2016 Mar 2;6:22597
Zoledronic acid suppresses transforming growth factor-β-induced fibrogenesis by human gingival fibroblasts.
Komatsu Y, Ibi M, Chosa N, Kyakumoto S, Kamo M, Shibata T, Sugiyama Y, Ishisaki A
International journal of molecular medicine 2016 Jul;38(1):139-47
International journal of molecular medicine 2016 Jul;38(1):139-47
COMP-assisted collagen secretion--a novel intracellular function required for fibrosis.
Schulz JN, Nüchel J, Niehoff A, Bloch W, Schönborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F, Eckes B
Journal of cell science 2016 Feb 15;129(4):706-16
Journal of cell science 2016 Feb 15;129(4):706-16
A Bioinspired Ultraporous Nanofiber-Hydrogel Mimic of the Cartilage Extracellular Matrix.
Formica FA, Öztürk E, Hess SC, Stark WJ, Maniura-Weber K, Rottmar M, Zenobi-Wong M
Advanced healthcare materials 2016 Dec;5(24):3129-3138
Advanced healthcare materials 2016 Dec;5(24):3129-3138
Vitronectin-Based, Biomimetic Encapsulating Hydrogel Scaffolds Support Adipogenesis of Adipose Stem Cells.
Clevenger TN, Hinman CR, Ashley Rubin RK, Smither K, Burke DJ, Hawker CJ, Messina D, Van Epps D, Clegg DO
Tissue engineering. Part A 2016 Apr;22(7-8):597-609
Tissue engineering. Part A 2016 Apr;22(7-8):597-609
β1 Integrins Mediate Attachment of Mesenchymal Stem Cells to Cartilage Lesions.
Zwolanek D, Flicker M, Kirstätter E, Zaucke F, van Osch GJ, Erben RG
BioResearch open access 2015;4(1):39-53
BioResearch open access 2015;4(1):39-53
CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice.
O'Flaherty BM, Matar CG, Wakeman BS, Garcia A, Wilke CA, Courtney CL, Moore BB, Speck SH
PloS one 2015;10(8):e0135719
PloS one 2015;10(8):e0135719
MKL1 is an epigenetic modulator of TGF-β induced fibrogenesis.
Fan Z, Hao C, Li M, Dai X, Qin H, Li J, Xu H, Wu X, Zhang L, Fang M, Zhou B, Tian W, Xu Y
Biochimica et biophysica acta 2015 Sep;1849(9):1219-28
Biochimica et biophysica acta 2015 Sep;1849(9):1219-28
Endothelial-to-mesenchymal transition drives atherosclerosis progression.
Chen PY, Qin L, Baeyens N, Li G, Afolabi T, Budatha M, Tellides G, Schwartz MA, Simons M
The Journal of clinical investigation 2015 Oct 26;125(12):4514-28
The Journal of clinical investigation 2015 Oct 26;125(12):4514-28
A novel profibrotic mechanism mediated by TGFβ-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells.
Luo Y, Xu W, Chen H, Warburton D, Dong R, Qian B, Selman M, Gauldie J, Kolb M, Shi W
The Journal of pathology 2015 Jul;236(3):384-94
The Journal of pathology 2015 Jul;236(3):384-94
Assessing the accuracy and reproducibility of modality independent elastography in a murine model of breast cancer.
Weis JA, Flint KM, Sanchez V, Yankeelov TE, Miga MI
Journal of medical imaging (Bellingham, Wash.) 2015 Jul;2(3):036001
Journal of medical imaging (Bellingham, Wash.) 2015 Jul;2(3):036001
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Zhou Y, Nakao S, Sassa Y, Oshima Y, Takao K, Shimahara A, Yoshikawa K, Hamasaki T, Ohgi T, Hayashi H, Matsuda A, Kudo A, Nozaki M, Ogura Y, Kuroda M, Ishibashi T
Gene therapy 2015 Feb;22(2):127-37
Gene therapy 2015 Feb;22(2):127-37
Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells.
Bohanon FJ, Wang X, Graham BM, Prasai A, Vasudevan SJ, Ding C, Ding Y, Radhakrishnan GL, Rastellini C, Zhou J, Radhakrishnan RS
Molecular and cellular biochemistry 2015 Dec;410(1-2):293-300
Molecular and cellular biochemistry 2015 Dec;410(1-2):293-300
Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis.
Bohanon FJ, Wang X, Graham BM, Ding C, Ding Y, Radhakrishnan GL, Rastellini C, Zhou J, Radhakrishnan RS
The Journal of surgical research 2015 Dec;199(2):441-9
The Journal of surgical research 2015 Dec;199(2):441-9
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Wu L, Li N, Zhang M, Xue SL, Cassady K, Lin Q, Riggs AD, Zeng D
Proceedings of the National Academy of Sciences of the United States of America 2015 Dec 29;112(52):15994-9
Proceedings of the National Academy of Sciences of the United States of America 2015 Dec 29;112(52):15994-9
Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase.
Xu X, Dai H, Geng J, Wan X, Huang X, Li F, Jiang D, Wang C
Laboratory investigation; a journal of technical methods and pathology 2015 Aug;95(8):846-59
Laboratory investigation; a journal of technical methods and pathology 2015 Aug;95(8):846-59
Interaction of biomechanics with extracellular matrix components in abdominal aortic aneurysm wall.
Tanios F, Gee MW, Pelisek J, Kehl S, Biehler J, Grabher-Meier V, Wall WA, Eckstein HH, Reeps C
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2015 Aug;50(2):167-74
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2015 Aug;50(2):167-74
Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue.
Burgstaller G, Vierkotten S, Lindner M, Königshoff M, Eickelberg O
American journal of physiology. Lung cellular and molecular physiology 2015 Aug 15;309(4):L323-32
American journal of physiology. Lung cellular and molecular physiology 2015 Aug 15;309(4):L323-32
Second-generation compound for the modulation of utrophin in the therapy of DMD.
Guiraud S, Squire SE, Edwards B, Chen H, Burns DT, Shah N, Babbs A, Davies SG, Wynne GM, Russell AJ, Elsey D, Wilson FX, Tinsley JM, Davies KE
Human molecular genetics 2015 Aug 1;24(15):4212-24
Human molecular genetics 2015 Aug 1;24(15):4212-24
Long-term type 1 diabetes alters the deposition of collagens and proteoglycans in the early pregnant myometrium of mice.
Favaro RR, Raspantini PR, Salgado RM, Fortes ZB, Zorn TM
Histology and histopathology 2015 Apr;30(4):435-44
Histology and histopathology 2015 Apr;30(4):435-44
Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.
Lörchner H, Pöling J, Gajawada P, Hou Y, Polyakova V, Kostin S, Adrian-Segarra JM, Boettger T, Wietelmann A, Warnecke H, Richter M, Kubin T, Braun T
Nature medicine 2015 Apr;21(4):353-62
Nature medicine 2015 Apr;21(4):353-62
Identification of a collagen type I adhesin of Bacteroides fragilis.
Galvão BP, Weber BW, Rafudeen MS, Ferreira EO, Patrick S, Abratt VR
PloS one 2014;9(3):e91141
PloS one 2014;9(3):e91141
Megakaryocytic leukemia 1 (MKL1) regulates hypoxia induced pulmonary hypertension in rats.
Yuan Z, Chen J, Chen D, Xu G, Xia M, Xu Y, Gao Y
PloS one 2014;9(3):e83895
PloS one 2014;9(3):e83895
3-D adipocyte differentiation and peri-adipocyte collagen turnover.
Chun TH, Inoue M
Methods in enzymology 2014;538:15-34
Methods in enzymology 2014;538:15-34
Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation.
Ryzhov S, Sung BH, Zhang Q, Weaver A, Gumina RJ, Biaggioni I, Feoktistov I
Purinergic signalling 2014 Sep;10(3):477-86
Purinergic signalling 2014 Sep;10(3):477-86
TGF-β2-mediated ocular hypertension is attenuated in SPARC-null mice.
Swaminathan SS, Oh DJ, Kang MH, Shepard AR, Pang IH, Rhee DJ
Investigative ophthalmology & visual science 2014 Jun 6;55(7):4084-97
Investigative ophthalmology & visual science 2014 Jun 6;55(7):4084-97
Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis.
Bohanon FJ, Wang X, Ding C, Ding Y, Radhakrishnan GL, Rastellini C, Zhou J, Radhakrishnan RS
The Journal of surgical research 2014 Jul;190(1):55-63
The Journal of surgical research 2014 Jul;190(1):55-63
Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1.
Saitta B, Passarini J, Sareen D, Ornelas L, Sahabian A, Argade S, Krakow D, Cohn DH, Svendsen CN, Rimoin DL
Stem cells and development 2014 Jul 1;23(13):1464-78
Stem cells and development 2014 Jul 1;23(13):1464-78
FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney.
Fetting JL, Guay JA, Karolak MJ, Iozzo RV, Adams DC, Maridas DE, Brown AC, Oxburgh L
Development (Cambridge, England) 2014 Jan;141(1):17-27
Development (Cambridge, England) 2014 Jan;141(1):17-27
A novel murine model of hypertrophic scarring using subcutaneous infusion of bleomycin.
Cameron AM, Adams DH, Greenwood JE, Anderson PJ, Cowin AJ
Plastic and reconstructive surgery 2014 Jan;133(1):69-78
Plastic and reconstructive surgery 2014 Jan;133(1):69-78
Stk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity.
Lai LP, Lotinun S, Bouxsein ML, Baron R, McMahon AP
Bone 2014 Dec;69:98-108
Bone 2014 Dec;69:98-108
miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis.
Berschneider B, Ellwanger DC, Baarsma HA, Thiel C, Shimbori C, White ES, Kolb M, Neth P, Königshoff M
The international journal of biochemistry & cell biology 2014 Aug;53:432-41
The international journal of biochemistry & cell biology 2014 Aug;53:432-41
AMP-activated protein kinase regulates intraocular pressure, extracellular matrix, and cytoskeleton in trabecular meshwork.
Chatterjee A, Villarreal G Jr, Oh DJ, Kang MH, Rhee DJ
Investigative ophthalmology & visual science 2014 Apr 8;55(5):3127-39
Investigative ophthalmology & visual science 2014 Apr 8;55(5):3127-39
Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts.
Li P, Liang ML, Zhu Y, Gong YY, Wang Y, Heng D, Lin L
World journal of gastroenterology 2014 Apr 28;20(16):4648-61
World journal of gastroenterology 2014 Apr 28;20(16):4648-61
AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction.
Cieslik KA, Taffet GE, Crawford JR, Trial J, Mejia Osuna P, Entman ML
Journal of molecular and cellular cardiology 2013 Oct;63:26-36
Journal of molecular and cellular cardiology 2013 Oct;63:26-36
IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver.
Liu C, Billadeau DD, Abdelhakim H, Leof E, Kaibuchi K, Bernabeu C, Bloom GS, Yang L, Boardman L, Shah VH, Kang N
The Journal of clinical investigation 2013 Mar;123(3):1138-56
The Journal of clinical investigation 2013 Mar;123(3):1138-56
The effects of fibrin and fibrin-agarose on the extracellular matrix profile of bioengineered oral mucosa.
San Martin S, Alaminos M, Zorn TM, Sánchez-Quevedo MC, Garzón I, Rodriguez IA, Campos A
Journal of tissue engineering and regenerative medicine 2013 Jan;7(1):10-9
Journal of tissue engineering and regenerative medicine 2013 Jan;7(1):10-9
Ascorbate enhances elastin synthesis in 3D tissue-engineered pulmonary fibroblasts constructs.
Derricks KE, Rich CB, Buczek-Thomas JA, Nugent MA
Tissue & cell 2013 Aug;45(4):253-60
Tissue & cell 2013 Aug;45(4):253-60
Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury.
Osterholzer JJ, Olszewski MA, Murdock BJ, Chen GH, Erb-Downward JR, Subbotina N, Browning K, Lin Y, Morey RE, Dayrit JK, Horowitz JC, Simon RH, Sisson TH
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3447-57
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3447-57
CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis.
Gharaee-Kermani M, Kasina S, Moore BB, Thomas D, Mehra R, Macoska JA
PloS one 2012;7(11):e49278
PloS one 2012;7(11):e49278
Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation.
Perugorria MJ, Wilson CL, Zeybel M, Walsh M, Amin S, Robinson S, White SA, Burt AD, Oakley F, Tsukamoto H, Mann DA, Mann J
Hepatology (Baltimore, Md.) 2012 Sep;56(3):1129-39
Hepatology (Baltimore, Md.) 2012 Sep;56(3):1129-39
Proteoglycan and collagen expression during human air conducting system development.
Godoy-Guzmán C, San Martin S, Pereda J
European journal of histochemistry : EJH 2012 Jun 29;56(3):e29
European journal of histochemistry : EJH 2012 Jun 29;56(3):e29
Hepatic steatosis, fibrosis, and cancer in elderly cadavers.
Mak KM, Kwong AJ, Chu E, Hoo NM
Anatomical record (Hoboken, N.J. : 2007) 2012 Jan;295(1):40-50
Anatomical record (Hoboken, N.J. : 2007) 2012 Jan;295(1):40-50
Lanthanum carbonate, like sevelamer-HCl, retards the progression of vascular calcification and atherosclerosis in uremic apolipoprotein E-deficient mice.
Nikolov IG, Joki N, Nguyen-Khoa T, Guerrera IC, Maizel J, Benchitrit J, Machado dos Reis L, Edelman A, Lacour B, Jorgetti V, Drüeke TB, Massy ZA
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012 Feb;27(2):505-13
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012 Feb;27(2):505-13
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway.
Finsen AV, Lunde IG, Sjaastad I, Østli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nygård S, Wilcox-Adelman SA, Goetinck PF, Lyberg T, Skrbic B, Florholmen G, Tønnessen T, Louch WE, Djurovic S, Carlson CR, Christensen G
PloS one 2011;6(12):e28302
PloS one 2011;6(12):e28302
High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation.
Maharjan AS, Pilling D, Gomer RH
PloS one 2011;6(10):e26078
PloS one 2011;6(10):e26078
Globular domain of adiponectin: promising target molecule for detection of atherosclerotic lesions.
Almer G, Saba-Lepek M, Haj-Yahya S, Rohde E, Strunk D, Fröhlich E, Prassl R, Mangge H
Biologics : targets & therapy 2011;5:95-105
Biologics : targets & therapy 2011;5:95-105
Dynamic mechanical stimulations induce anisotropy and improve the tensile properties of engineered tissues produced without exogenous scaffolding.
Gauvin R, Parenteau-Bareil R, Larouche D, Marcoux H, Bisson F, Bonnet A, Auger FA, Bolduc S, Germain L
Acta biomaterialia 2011 Sep;7(9):3294-301
Acta biomaterialia 2011 Sep;7(9):3294-301
Coordinated regulation of extracellular matrix synthesis by the microRNA-29 family in the trabecular meshwork.
Villarreal G Jr, Oh DJ, Kang MH, Rhee DJ
Investigative ophthalmology & visual science 2011 May 1;52(6):3391-7
Investigative ophthalmology & visual science 2011 May 1;52(6):3391-7
Calcium concrements in the pineal gland of the Arctic fox (Vulpes lagopus) and their relationship to pinealocytes, glial cells and type I and III collagen fibers.
Bulc M, Lewczuk B, Prusik M, Gugołek A, Przybylska-Gornowicz B
Polish journal of veterinary sciences 2010;13(2):269-78
Polish journal of veterinary sciences 2010;13(2):269-78
The effects of aging on the molecular and cellular composition of the prostate microenvironment.
Bianchi-Frias D, Vakar-Lopez F, Coleman IM, Plymate SR, Reed MJ, Nelson PS
PloS one 2010 Sep 1;5(9)
PloS one 2010 Sep 1;5(9)
Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum.
Curnow SJ, Fairclough M, Schmutz C, Kissane S, Denniston AK, Nash K, Buckley CD, Lord JM, Salmon M
PloS one 2010 Mar 18;5(3):e9730
PloS one 2010 Mar 18;5(3):e9730
Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells.
Cao S, Yaqoob U, Das A, Shergill U, Jagavelu K, Huebert RC, Routray C, Abdelmoneim S, Vasdev M, Leof E, Charlton M, Watts RJ, Mukhopadhyay D, Shah VH
The Journal of clinical investigation 2010 Jul;120(7):2379-94
The Journal of clinical investigation 2010 Jul;120(7):2379-94
Characterization of differential properties of rabbit tendon stem cells and tenocytes.
Zhang J, Wang JH
BMC musculoskeletal disorders 2010 Jan 18;11:10
BMC musculoskeletal disorders 2010 Jan 18;11:10
Platelet-rich plasma releasate promotes differentiation of tendon stem cells into active tenocytes.
Zhang J, Wang JH
The American journal of sports medicine 2010 Dec;38(12):2477-86
The American journal of sports medicine 2010 Dec;38(12):2477-86
Improved serum-free culture conditions for spleen-derived murine fibrocytes.
Crawford JR, Pilling D, Gomer RH
Journal of immunological methods 2010 Dec 15;363(1):9-20
Journal of immunological methods 2010 Dec 15;363(1):9-20
VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats.
Farkas L, Farkas D, Ask K, Möller A, Gauldie J, Margetts P, Inman M, Kolb M
The Journal of clinical investigation 2009 May;119(5):1298-311
The Journal of clinical investigation 2009 May;119(5):1298-311
Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria.
Pinheiro SVB, Ferreira AJ, Kitten GT, da Silveira KD, da Silva DA, Santos SHS, Gava E, Castro CH, Magalhães JA, da Mota RK, Botelho-Santos GA, Bader M, Alenina N, Santos RAS, Simoes E Silva AC
Kidney international 2009 Jun;75(11):1184-1193
Kidney international 2009 Jun;75(11):1184-1193
Collagen-based fibrous scaffold for spatial organization of encapsulated and seeded human mesenchymal stem cells.
Yow SZ, Quek CH, Yim EK, Lim CT, Leong KW
Biomaterials 2009 Feb;30(6):1133-42
Biomaterials 2009 Feb;30(6):1133-42
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The Journal of biological chemistry 2008 May 23;283(21):14213-20
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The Journal of biological chemistry 2004 Mar 19;279(12):11392-401
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Journal of reproduction and fertility 2000 May;119(1):49-58
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Supportive validation
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- Rockland Immunochemicals, Inc. (provider)
- Main image
- Experimental details
- Western blot analysis is shown using Rockland's Affinity Purified anti-Collagen I antibody to detect expression of collagen I in Wistar rat hepatic stellate cells (HSC) in control (GFP-transduced) (left lane) and PPARg-transduced cell lysates (right lane). Protein staining shown below each blot depicts equal protein loading. An equal amount of the whole cell protein (100 µg) was separated by SDS-PAGE and electroblotted to nitro-cellulose membranes. Proteins were detected by incubating the membrane with anti-Collagen I antibody at a concentration of 0.22 µg/10 ml in TBS (100 mM Tris-HCl, 0.15 M NaCl, pH 7.4) with 5% Non-fat milk. Detection occurred by incubation with a horseradish peroxidase-conjugated secondary antibody at 1 µg/10 ml. Proteins were detected by a chemiluminescent method using the PIERCE ECL kit (Amersham Biosciences). Other detection systems will yield similar results. See Hazra et al. (2004) for additional details.
- Validation comment
- Western Blot
