Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 12994-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12994-1-AP, RRID:AB_10644276
- Product name
- SIRT7 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIRT7 antibody (Cat. #12994-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells.
Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine.
The effects of A549 and H1299 cell-derived exosomes on the proliferation and apoptosis of BEAS-2B cells.
Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway.
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.
An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy.
High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.
Zhang W, Yang J, Chen Y, Xue R, Mao Z, Lu W, Jiang Y
Aging cell 2021 Feb;20(2):e13307
Aging cell 2021 Feb;20(2):e13307
Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine.
Okada N, Oshima K, Iwasaki Y, Maruko A, Matsumura K, Iioka E, Vu TD, Fujitsuka N, Nishi A, Sugiyama A, Nishiyama M, Kaneko A, Mizoguchi K, Yamamoto M, Nishimura S
Gene 2021 Aug 20;794:145752
Gene 2021 Aug 20;794:145752
The effects of A549 and H1299 cell-derived exosomes on the proliferation and apoptosis of BEAS-2B cells.
Li Z, Chen X, Yi X
Die Pharmazie 2021 Aug 1;76(8):379-387
Die Pharmazie 2021 Aug 1;76(8):379-387
Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling.
Zhao Y, Ye X, Chen R, Gao Q, Zhao D, Ling C, Qian Y, Xu C, Tao M, Xie Y
Oncology reports 2020 Sep;44(3):959-972
Oncology reports 2020 Sep;44(3):959-972
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway.
Chen KL, Li L, Li CM, Wang YR, Yang FX, Kuang MQ, Wang GL
Oxidative medicine and cellular longevity 2019;2019:3187972
Oxidative medicine and cellular longevity 2019;2019:3187972
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer.
Sun X, Wang S, Li Q
Frontiers in genetics 2019;10:879
Frontiers in genetics 2019;10:879
SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells.
Chen KL, Li L, Yang FX, Li CM, Wang YR, Wang GL
Journal of cellular physiology 2018 Sep;233(9):6767-6778
Journal of cellular physiology 2018 Sep;233(9):6767-6778
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413
Nature communications 2017 Sep 4;8(1):413
MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.
Cheng L, Zhu Y, Han H, Zhang Q, Cui K, Shen H, Zhang J, Yan J, Prochownik E, Li Y
Cell death & disease 2017 Jul 13;8(7):e2916
Cell death & disease 2017 Jul 13;8(7):e2916
An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy.
Sun L, Xia WY, Zhao SH, Liu N, Liu SS, Xiu P, Li LF, Cao XL, Gao JX
International journal of oncology 2016 Jun;48(6):2461-71
International journal of oncology 2016 Jun;48(6):2461-71
High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.
Geng Q, Peng H, Chen F, Luo R, Li R
International journal of clinical and experimental pathology 2015;8(2):1938-45
International journal of clinical and experimental pathology 2015;8(2):1938-45
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 12994-1-AP(SIRT7 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIRT7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIRT7. This antibody recognizes human, mouse, rat antigen. The SIRT7 antibody has been validated for the following applications: ELISA, WB, IHC analysis.