RAPH1

This gene encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which function in cell migration. Members of this family contain pleckstrin-homology domains, Ras-association domains, and proline-rich C-termini. The protein encoded by this gene regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Description

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

Tissue specificity

Tissue enhanced (liver)

Subcell location

Nuclear bodies, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (203394345 - 203535335)

Ensembl ID

ENSG00000173166  (ver. 103.38)

Orthologs

Mouse Raph1: ENSMUSG00000026014

UniProt

Q70E73

neXtProt

NX_Q70E73

Human splice variants
Mouse splice variants

Protein structure