349903

antibody from BioLegend

Targeting: CTLA4 CD, CD152, CELIAC3, CTLA-4, GSE, IDDM12

Blocking/Neutralizing

Antibody data

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Validation data

Product number: 349903 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#349903, RRID:AB_10640742
Product name: LEAF™ Purified anti-human CD152 (CTLA-4) [L3D10]
Antibody type: Monoclonal
Antigen: Extracellular domain of human CTLA-4 and human IgG1 Fc fusion protein
Description: CD152, also known as Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), is a 33 kD member of the immunoglobulin superfamily. It is transiently expressed on activated T cells. Regulatory T cells express high level of CTLA-4. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization. Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses through interaction with CD80 (B7-1) and CD86 (B7-2) present on antigen presenting cells (APC). CD152 is thought to play a role in the induction and maintenance of immunological tolerance, as well as the development of protective immunity and thymocyte regulation.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 50 µg
Concentration: 1 mg/ml
Storage: The antibody solution should be stored undiluted at 4°C. This LEAF™ solution contains no preservative; handle under aseptic conditions.

CTLA4 protein structure - 349903 shown in red.