Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- GTX103977 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX103977, RRID:AB_2036842
- Product name
- EIF4E2 antibody [N1C3]
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse
- Host
- Rabbit
Submitted references Translational control of ERK signaling through miRNA/4EHP-directed silencing.
Cap-binding protein 4EHP effects translation silencing by microRNAs.
The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.
Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo.
Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation.
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.
Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression.
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N
eLife 2018 Feb 7;7
eLife 2018 Feb 7;7
Cap-binding protein 4EHP effects translation silencing by microRNAs.
Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N
Proceedings of the National Academy of Sciences of the United States of America 2017 May 23;114(21):5425-5430
Proceedings of the National Academy of Sciences of the United States of America 2017 May 23;114(21):5425-5430
The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.
Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N
Nature communications 2017 Jul 7;8:16056
Nature communications 2017 Jul 7;8:16056
Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo.
Sesé M, Fuentes P, Esteve-Codina A, Béjar E, McGrail K, Thomas G, Aasen T, Ramón Y Cajal S
Oncotarget 2017 Dec 29;8(70):114856-114876
Oncotarget 2017 Dec 29;8(70):114856-114876
Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation.
Timpano S, Uniacke J
The Journal of biological chemistry 2016 May 13;291(20):10772-82
The Journal of biological chemistry 2016 May 13;291(20):10772-82
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.
Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J
RNA (New York, N.Y.) 2016 Mar;22(3):373-82
RNA (New York, N.Y.) 2016 Mar;22(3):373-82
Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression.
Uniacke J, Perera JK, Lachance G, Francisco CB, Lee S
Cancer research 2014 Mar 1;74(5):1379-89
Cancer research 2014 Mar 1;74(5):1379-89
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N
Molecular and cellular biology 2012 Sep;32(17):3585-93
Molecular and cellular biology 2012 Sep;32(17):3585-93
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Supportive validation
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- GeneTex (provider)
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- Experimental details
- EIF4E2 antibody [N1C3] detects EIF4E2 protein at cytoplasm on human breast carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. EIF4E2 antibody [N1C3] (GTX103977) diluted at 1:500.